Circulation: Heart Failure

JANUARY 28, 2025

BACKGROUND:The therapeutic armamentarium for heart failure with preserved ejection fraction (HFpEF) remains notably constrained. The generated organoids were then subjected to HFpEF-associated, comorbidity-inspired conditions, such as hypertension, diabetes, and obesity-related inflammation.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Obesity Diabetes 40

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Obesity Heart Failure BMI 40

Heart BMJ

FEBRUARY 23, 2024

Objective The heterogeneous pathophysiology of the diverse heart failure with preserved ejection fraction (HFpEF) phenotypes needs to be examined. We aim to assess differences in the biomarkers among the phenotypes of HFpEF and investigate its multifactorial pathophysiology.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Hypertension 40

Hypertension Journal

FEBRUARY 22, 2024

Hypertension, Ahead of Print. Background:We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA) at rest and sympathetic reactivity during a cold pressor test compared with non–heart failure controls.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Blood Pressure Physiology 40

American College of Cardiology

JULY 11, 2024

What is the safety and efficacy of tadalafil in patients with heart failure with preserved ejection fraction (HFpEF) and combined postcapillary and precapillary pulmonary hypertension (CpcPH)?

Preserved Ejection Fraction 48

Preserved Ejection Fraction Heart Failure Pulmonary Hypertension 48

Circulation

MARCH 16, 2025

Circulation, Volume 151, Issue 11 , Page e763-e763, March 18, 2025.

Preserved Ejection Fraction 45

Preserved Ejection Fraction Heart Failure Pulmonary Hypertension 45

Circulation

MARCH 9, 2025

Circulation, Volume 151, Issue 10 , Page e686-e686, March 11, 2025.

Preserved Ejection Fraction 45

Preserved Ejection Fraction Article Heart Failure Pulmonary 45

HeartRhythm

APRIL 30, 2024

Introduction: Patients with ‘heart failure with preserved ejection fraction’ (HFpEF) frequently manifest chronotropic incompetence as well as hypertension (HTN). Cardiac pacing may improve clinical outcomes in these patients. To date, pacing has not been regulated by an external hemodynamic input.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Hypertension Blood Pressure Pacemaker 40

Journal of the American Heart Association

DECEMBER 29, 2023

Journal of the American Heart Association, Ahead of Print.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Pulmonary Heart Failure Hypertension 40

European Journal of Heart Failure

NOVEMBER 19, 2024

Hypertensive disorders of pregnancy as a risk factor for heart failure. Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations and preeclampsia, a more severe form, in 34%. BMI, body mass index; CV, cardiovascular; CVD, cardiovascular disease; HELLP, haemolysis, elevated liver enzymes, low platelet count.

Risk Factors 40

Risk Factors Heart Failure Hypertension Preserved Ejection Fraction 40

Circulation

NOVEMBER 11, 2024

Intro:Drug Development for Heart failure with Preserved Ejection Fraction (HFpEF) is a major challenge facing cardiovascular research due to its complex pathophysiology and existence of comorbidities, leading to recognize distinct HFpEF phenogroups. l) for 8 weeks.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Hypertension Blood Pressure Obesity 40

DAIC

JANUARY 23, 2024

Until today, there was only one serious adverse event of short-term hypertension at 12 weeks after the last DSR therapy, which was adjudicated as non-related to DSR therapy. Short-term hypertension is often seen in this very sick patient population. up to daily for four weeks, followed by a three-month safety follow-up period.

Heart Failure 104

Heart Failure Preserved Ejection Fraction Hypertension Cancer 104

Circulation

APRIL 1, 2025

BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Circulation, Ahead of Print. Cardiac lymphatics play a crucial role in maintaining heart health by draining fluids and immune cells.

Preserved Ejection Fraction 45

Preserved Ejection Fraction Obesity Heart Failure Hypertension 45

Dr. S. Venkatesan MD

AUGUST 3, 2024

However, It is surprising even in chronic pulmonary hypertension , the degree of RVH is not constant and homogenous.This is because , different parts of RV chamber has different wall thickness.Further, the pressure distribution from PA to RV is uneven. This may be correct when there is acute raise in RV after load, as in PE.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Pulmonary Heart Dysfunction 52

Dr. S. Venkatesan MD

APRIL 18, 2024

Shah, author of Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. Here is an audio podcast from the primary author published in JAMA network. Interview with Sanjiv J. Hosted by James E.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Pulmonary Congenital Heart Disease VSD 40

Circulation

NOVEMBER 11, 2024

The CardioMEMS PA (pulmonary artery) sensor allows remote pulmonary artery diastolic (PAD) pressure monitoring to adjust diuresis in heart failure with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Cardiomyopathy Heart Failure Pulmonary 40

Circulation

NOVEMBER 11, 2024

Introduction:Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure which is rapidly rising in incidence in the US today. g/L of an iNOS inhibitor (N-Nitro-L-arginine methylester) to induce hypertension. Circulation, Volume 150, Issue Suppl_1 , Page A4134456-A4134456, November 12, 2024.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Echocardiogram Exercise Diet 40

DAIC

FEBRUARY 29, 2024

ET Main Tent (Hall B1) Effect of Gamification, Financial Incentives or Both Combined to Increase Physical Activity Among Patients with Elevated Risk For Major Adverse Cardiovascular Events.

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

European Journal of Heart Failure

APRIL 13, 2025

The beneficial effects of finerenone in patients with heart failure (HF) and mildly reduced or preserved ejection fraction were consistent, regardless of a history of chronic obstructive pulmonary disease (COPD) status.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Pulmonary Peripheral Arterial Disease 40

DAIC

MARCH 26, 2025

live with HF, 2 a complex clinical syndrome with symptoms and signs that result from any structural or functional impairment of ventricular filling or ejection of blood. 2 Most are balancing multiple comorbidities, such as obesity, diabetes, hypertension and chronic kidney disease (CKD). 4 Approximately 6.7 million adults in the U.S.

Heart Failure 52

Heart Failure Preserved Ejection Fraction Kidney Disease ACE Inhibitor 52

Circulation

OCTOBER 13, 2023

BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preserved ejection fraction. Nonresistant hypertension was defined as BP above threshold but not meeting aTRH criteria. Rates of the primary outcome were 8.7

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Hypertension Myocardial Infarction 40

European Journal of Heart Failure

APRIL 6, 2025

During a median follow-up of 12.6years, 349 (4.3%) HF events occurred of which 118 (33.8%) had HF with preserved ejection fraction. Methods and results We included a total of 8199 individuals from the Prevention of REnal and Vascular End-stage Disease (PREVEND) community-based cohort (mean age: 49.8years; 50.1%

Heart Failure 40

Heart Failure Preserved Ejection Fraction Cholesterol Obesity 40

European Journal of Heart Failure

FEBRUARY 5, 2025

Beta-blockers are commonly used in patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF). Methods and results We pooled individual patient data from four large HFmrEF/HFpEF trials (I-Preserve, TOPCAT, PARAGON-HF, and DELIVER).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Outcomes Atrial Fibrillation 40

European Journal of Heart Failure

FEBRUARY 4, 2024

Phenomics analyses identified unique druggable inflammatory markers in HFpEF from the tumour necrosis factor receptor superfamily (TNFRSF), which were positively associated with hypertension, diabetes, and increased posterior and relative wall thickness.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Diabetes 40

Circulation

NOVEMBER 11, 2024

Introduction:The demographics of patients with pulmonary arterial hypertension (PAH) is shifting towards older age, increased comorbidity burden, and an increase in the risk of left ventricular (LV) diastolic dysfunction. 2022 were included.

Pulmonary 40

Pulmonary Hypertension Preserved Ejection Fraction Outcomes 40

DAIC

MARCH 29, 2024

HFpEF is HF with preserved ejection fraction in which pressure builds up in the heart and lungs due to a stiffened left ventricle. This type of HF is largely associated with obesity and hypertension. There are two types of HF.

Preserved Ejection Fraction 111

Preserved Ejection Fraction Heart Failure Quality of Life Hospital 111

Frontiers in Cardiovascular Medicine

AUGUST 6, 2024

Hypertension during pregnancy affects up to 10% of pregnancies and is associated with significant cardiovascular morbidity and mortality. Finally, we explore how future cardiovascular risk may be predicted based on cardiac remodelling during or after pregnancy and suggest potential areas of further research in the field.

Heart Failure 40

Heart Failure Preserved Ejection Fraction Coronary Artery Disease Hypertension 40

DAIC

JUNE 26, 2024

The analysis sought to determine whether phenotypic features and treatment effects of semaglutide vary by sex in obesity-related heart failure ( HF ) with preserved ejection fraction (HFpEF). Our study sheds light on these differences and the consistent benefits of semaglutide for women and men.”

Preserved Ejection Fraction 105

Preserved Ejection Fraction Obesity BMI Heart Failure 105

Open Heart

FEBRUARY 15, 2023

AFMR is likely to become more common with population ageing, alongside increases in atrial fibrillation and heart failure with preserved ejection fraction; conditions causing atrial dilatation. Advancing age and pulmonary hypertension independently associated with survival in FMR. for all-cause and 1.73, 95% CI 1.60

Bicuspid/Mitral 52

Bicuspid/Mitral Preserved Ejection Fraction Pulmonary Atrial Fibrillation 52

Journal of the American Heart Association

JANUARY 23, 2025

BackgroundCardiometabolic comorbidities such as obesity, diabetes, and hypertension are highly prevalent in heart failure (HF). Journal of the American Heart Association, Ahead of Print. Severely uncontrolled comorbidities were defined as systolic blood pressure 160 mm Hg, hemoglobin A1c 8%, and body mass index 35 kg/m2.

Heart Failure 45

Heart Failure Preserved Ejection Fraction Obesity Outcomes 45

Cardiometabolic Health Congress

JULY 25, 2023

There are significant data that show that if you have obesity, you have a high risk of developing coronary heart disease, heart failure, type 2 diabetes (T2D) or risk factors such as hypertension and dyslipidemia. [1] Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction.”

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

Journal of the American Heart Association

MARCH 13, 2025

The risk of allcause and noncardiovascular mortality and first allcause hospitalization was higher with EF values >55% in crude but not adjusted analyses.ConclusionsAmong patients with HF with preserved EF, 21% had EF 60%.

Preserved Ejection Fraction 70

Preserved Ejection Fraction Heart Failure Peripheral Arterial Disease Cardiomyopathy 70

Frontiers in Cardiovascular Medicine

DECEMBER 16, 2024

To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Heart Failure Hypertension 40

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Heart Failure Management : The FINEARTS-HF trial focused on the efficacy of finerenone, an aldosterone antagonist, in reducing heart failure hospitalizations and cardiovascular mortality among patients with preserved ejection fraction (HFpEF).

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59

The British Journal of Cardiology

JANUARY 14, 2025

We report from the 19 th Annual Scientific Meeting of the Cardiorenal Forum held in London on 4 th October 2024, which served as a dynamic platform for experts in cardiology, diabetes, and renal medicine to converge and exchange the latest insights on managing heart and kidney failure.

Innovation 40

Innovation Diabetes Preserved Ejection Fraction Outcomes 40

Open Heart

DECEMBER 3, 2024

Aims Pulmonary hypertension (PHT) appears to be very common in heart failure with preserved ejection fraction but details on its prevalence, severity and prognostic implications have not been well defined.

Pulmonary 52

Pulmonary Preserved Ejection Fraction Hypertension Atrial Fibrillation 52

Cardiometabolic Health Congress

NOVEMBER 14, 2024

42% of adults are considered obese , increasing their risk of diabetes, hypertension, and cardiovascular issues. Additionally, 10% of the global population suffers from chronic kidney disease , with diabetes and hypertension as significant risk factors. In the U.S.,

CME 103

CME Obesity Heart Failure Biomarkers 103