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Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance

Journal of the American Heart Association

Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation. Journal of the American Heart Association, Ahead of Print.

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Active plant substance found to reduce pulmonary hypertension

Medical Xpress - Cardiology

Pulmonary hypertension is a very serious disease that leads to heart failure and death in many patients.

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Development and Evaluation of a Deep Learning–Based Pulmonary Hypertension Screening Algorithm Using a Digital Stethoscope

Journal of the American Heart Association

BackgroundDespite the poor outcomes related to the presence of pulmonary hypertension, it often goes undiagnosed in part because of low suspicion and screening tools not being easily accessible such as echocardiography. Each 15second PCG, recorded using a digital stethoscope, was processed to generate 5second melspectrograms.

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Artificial intelligence to improve the diagnosis of pulmonary hypertension: promises and pitfalls

Heart BMJ

Challenges in the diagnosis of pulmonary hypertension Pulmonary hypertension (PH) is a clinical–physiological syndrome thought to affect 1% of the global population. Patients with PH experience symptoms including dyspnoea, fatigue and oedema, often associated with physical and psychosocial disability.

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Upregulation of Angiomotin-like 2 ameliorates experimental pulmonary arterial hypertension by inactivating YAP1 signaling

Journal of Cardiovascular Pharmacology

Abstract: Angiomotin-like 2 (AMOTL2) is related to numerous physiological and pathological conditions by affecting signal transduction. However, whether AMOTL2 is linked to pulmonary arterial hypertension (PAH) has not been addressed. AMOTL2 was downregulated in hypoxia-stimulated pulmonary arterial smooth muscle cells (PASMCs).

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Endothelin System in Hypertension and Chronic Kidney Disease

Hypertension Journal

Hypertension, Ahead of Print. ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions.

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Clinical risk associated with COVID-19 among 86000 patients with congenital heart disease

Open Heart

The excess risk of COVID-19 hospitalisation and death rose with increasing physiological severity of CHD (presence of pulmonary vascular disease and/or cyanosis), rather than anatomical complexity. Of patients with a positive COVID-19 test, patients with CHD were more likely than controls to be hospitalised (22.4%