FDA Approves Aprocitentan (Tryvio) for Treatment-Resistant Hypertension
HCPLive
MARCH 20, 2024
announced the FDA's approval of aprocitentan (Tryvio) for treatment-resistant hypertension on March 20, 2024. Idorsia Ltd.
Hypertension Related Topics 
Sotatercept's FDA Approval a New Chapter for Pulmonary Arterial Hypertension
Med Page Today
MARCH 27, 2024
(MedPage Today) -- The FDA approved sotatercept (Winrevair) for treating pulmonary arterial hypertension (PAH) in adults, Merck announced on Tuesday. A novel activin signaling inhibitor, sotatercept is indicated to increase exercise capacity.
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Gastric Bypass Surgery’s Durable Hypertension Impact
CardiacWire
FEBRUARY 11, 2024
The associations between obesity and hypertension are widely known, but a new JACC study reveals that weight-reducing gastric bypass surgery has a significant and lasting impact on patients’ need for antihypertensives. vs. 2.4%) All gastric bypass patients eliminated their resistant hypertension (from 15.2%
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Hypertension in Pregnancy and Women
HCPLive
DECEMBER 25, 2024
A panelist discusses how hypertensive disorders during pregnancy remain a leading cause of maternal mortality worldwide, affecting 5-10% of pregnancies and requiring careful monitoring, early detection, and appropriate medical management to protect both mother and baby.
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Mechanisms and treatment of pulmonary arterial hypertension
Nature Reviews - Cardiology
AUGUST 6, 2024
Nature Reviews Cardiology, Published online: 07 August 2024; doi:10.1038/s41569-024-01064-4 In this Review, Ghofrani and colleagues discuss the mechanisms underlying the development of pulmonary arterial hypertension, provide an overview of approved therapies and describe the predominantly non-vasodilatory drugs that are currently being tested in clinical (..)
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Dietary changes may treat pulmonary hypertension
Science Daily - Heart Disease
MAY 2, 2024
This difference becomes clear in pulmonary hypertension, in which only the lungs' blood vessels stiffen progressively, leading to chronic lung disease, heart failure and death.
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Better Cognitive Outcomes Tied to Vigorous Exercise in Hypertensive Adults
Med Page Today
JUNE 6, 2024
(MedPage Today) -- Vigorous exercise appeared to preserve cognitive function in older adults with hypertension, a post hoc analysis of SPRINT MIND trial data showed. At least one vigorous physical activity session per week reduced the risk of.
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Early-Life Sugar Restriction Reduced Diabetes, Hypertension Risk
Med Page Today
NOVEMBER 6, 2024
(MedPage Today) -- SAN ANTONIO -- Limiting exposure to sugar starting in utero reduced risk and delayed onset of type 2 diabetes and hypertension in adulthood, a study showed. Adults exposed to early-life sugar rationing in the U.K. for at least.
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Hypertension, Diabetes in Pregnancy Affects Offspring's Heart Health in Adolescence
Med Page Today
FEBRUARY 16, 2024
(MedPage Today) -- NATIONAL HARBOR, Md. -- Moms who had hypertensive disorders of pregnancy (HDP) or gestational diabetes mellitus (GDM) were more likely to have kids with worse cardiovascular health (CVH) in adolescence, a secondary analysis.
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Rise in Chronic Hypertension in Pregnancy While Treatment Stagnates
Med Page Today
JUNE 17, 2024
(MedPage Today) -- There was a steady increase in the prevalence of chronic hypertension in pregnancy over the last two decades, with some accompanying changes in treatment, a nationwide cohort study found. From 2008 to 2021, the prevalence of.
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Clinical characteristics, treatment, and blood pressure control in patients with hypertension seen by primary care physicians in Spain: the IBERICAN study
Frontiers in Cardiovascular Medicine
DECEMBER 20, 2023
Objectives To determine the clinical profile, according to the history of hypertension, the risk of developing hypertension, current antihypertensive treatment and BP control rates in patients with hypertension from the IBERICAN cohort. This analysis shows the baseline clinical characteristics of patients with hypertension.
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Kids With Hypertension May Have Twice the Risk of Cardiac Events
Med Page Today
MAY 6, 2024
(MedPage Today) -- Children diagnosed with hypertension had a higher associated long-term risk of major adverse cardiac events (MACE) compared with matched controls without the condition, according to a Canadian population-based, retrospective.
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Draw Between Two Diuretics for Renal Prevention in Hypertension
Med Page Today
MAY 16, 2024
(MedPage Today) -- LONG BEACH, Calif. -- Chlorthalidone was no better than hydrochlorothiazide for reducing the incidence of major renal outcomes in patients with hypertension, a secondary analysis of the randomized Diuretic Comparison Project.
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Intensive Blood Pressure Control in Individuals With Hypertension
JAMA Cardiology
JUNE 17, 2024
This randomized clinical trial investigates the effectiveness and safety of a nonphysician-led, multifaceted, intensive blood pressure intervention in younger and older individuals with hypertension.
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Postpartum Ambulatory Blood Pressure and New-Onset Hypertensive Disorders of Pregnancy
JAMA Cardiology
JUNE 11, 2024
This cohort study examines risk factors and characterizes outcomes for postpartum individuals with ongoing hypertension and severe hypertension following hospital discharge through a hospital system’s remote blood pressure management program.
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Aria CV Announces First Patient Successfully Implanted with Second-Generation Pulmonary Hypertension System
DAIC
FEBRUARY 27, 2024
milla1cf Tue, 02/27/2024 - 17:29 February 27, 2024 — Aria CV, Inc , a developer of medical devices treating pulmonary hypertension, today announced the first patient was implanted with the Gen 2 Aria CV Pulmonary Hypertension System as part of the ASPIRE PH clinical trial at Ascension St. Ashwin Ravichandran and Scott Hittinger.
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Researchers identify circulating proteins linked to preeclampsia and other hypertensive disorders of pregnancy
Medical Xpress - Cardiology
JANUARY 3, 2024
Preeclampsia and other hypertensive disorders of pregnancy—which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy—carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.
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Hypertension Before 40 Linked to Doubling of Stroke Risk in Black Women
HCPLive
FEBRUARY 2, 2024
Study presented at ISC 2024 suggests Black women with hypertension before age 35 face a 3-fold increase in risk of stroke while hypertension before 45 linked to doubling in stroke risk.
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105 Association found between dark chocolate consumption, reduced risk of essential hypertension
Medical Xpress - Cardiology
JANUARY 22, 2024
A team of cardiologists at Shaoxing People's Hospital, working with a colleague from Zhuji People's Hospital, both in China, has found an association between consumption of dark chocolate and reductions in the risk of essential hypertension.
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New insights and potential treatments for pulmonary hypertension
Science Daily - Heart Disease
AUGUST 21, 2024
A new study has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH).
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Salt Substitutes Reduces Hypertension in Older Adults
HCPLive
FEBRUARY 16, 2024
Older adults who use a salt substitute had a 40% lower incidence of experiencing hypertension than people who use regular salt.
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EHR Alerts Trigger Primary Care Clinics to Improve Hypertension Care in CKD
Med Page Today
MARCH 15, 2024
(MedPage Today) -- A computerized clinical decision support (CDS) tool for primary care helped lower blood pressure (BP) in patients with chronic kidney disease (CKD) and uncontrolled hypertension, a cluster-randomized trial found. When primary.
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Immune and inflammatory mechanisms in hypertension
Nature Reviews - Cardiology
JANUARY 2, 2024
Nature Reviews Cardiology, Published online: 03 January 2024; doi:10.1038/s41569-023-00964-1 In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, (..)
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Over Half of Adults With Uncontrolled Hypertension Unaware of Their Condition
Med Page Today
SEPTEMBER 17, 2024
adults with uncontrolled hypertension are unaware they have hypertension in the first place, according to a recent study in JAMA Network Open. (MedPage Today) -- More than half of U.S. Furthermore, more than two-thirds of those on treatment had.
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Irregular Sleeping Linked to Greater Risk of OSA, Hypertension
HCPLive
JANUARY 16, 2024
Compared to individuals without OSA and regular sleep, individuals with OSA combined with severely irregular sleep had the highest odds of hypertension, according to a new study.
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Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research
DAIC
MAY 8, 2024
Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension (PAH).
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Potassium-enriched salt is the missing ingredient in hypertension guidelines, say experts
Medical Xpress - Cardiology
JANUARY 25, 2024
A call to include recommendations on low-sodium potassium-enriched salt in hypertension treatment guidelines has been made by an international group of experts in the journal Hypertension.
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New-Onset Epilepsy, Migraine Tied to Hypertensive Disorders of Pregnancy
Med Page Today
DECEMBER 23, 2024
(MedPage Today) -- Hypertensive disorders of pregnancy -- gestational hypertension, preeclampsia, or eclampsia -- were tied to an increased risk of new-onset neurologic disorders years after giving birth, Swedish registry data showed.
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Cedars-Sinai Experts Studying Device for Controlling Treatment-Resistant Hypertension
DAIC
MARCH 18, 2024
and the first on the West Coast to use a new device aimed at lowering blood pressure in patients with difficult-to-treat hypertension. milla1cf Mon, 03/18/2024 - 08:00 March 18, 2024 — The Smidt Heart Institute at Cedars-Sinai recently became one of four institutions in the U.S. Food and Drug Administration approved it in late 2023.
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Unique Cell-based Approach for Pulmonary Arterial Hypertension Shown to Be Safe
DAIC
DECEMBER 13, 2023
Pulmonary arterial hypertension, a form of high blood pressure that occurs in the lungs, is a target of research by Cedars-Sinai investigators. Pulmonary arterial hypertension is a rare disease, affecting fewer than 100 people per million. Siegel Family Foundation Distinguished Professor and senior author of the study. “We
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SGLT2 Inhibitors Tied to Better Outcomes in Pulmonary Arterial Hypertension
Med Page Today
OCTOBER 7, 2024
(MedPage Today) -- BOSTON -- Sodium-glucose cotransporter-2 (SGLT2) inhibitors were linked to long-term reductions in mortality risk among patients with pulmonary arterial hypertension (PAH), according to an observational cohort study.
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Reviva Announces Grant of European Patent Covering Use of Brilaroxazine for the Treatment of Pulmonary Hypertension
DAIC
JULY 10, 2024
“This latest patent further secures the broad therapeutic potential of brilaroxazine for inflammatory conditions driven by underlying disruption in serotonin signaling like pulmonary hypertension,” said Laxminarayan Bhat, Ph.D. Founder, President, and CEO. Brilaroxazine has already received Orphan Drug Designation by the U.S.
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Orchestra BioMed Announces Initiation of BACKBEAT Pivotal Study of AVIM Therapy in Hypertensive Pacemaker Patients
DAIC
JANUARY 19, 2024
The BACKBEAT pivotal study will evaluate the efficacy and safety of atrioventricular interval modulation (“AVIM”) therapy (also known as BackBeat CNT), for the treatment of pacemaker-indicated patients with uncontrolled hypertension despite the use of antihypertensive medications. Orchestra BioMed and Medtronic, Inc. Kowal, M.D., and Europe.
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Adverse Social Determinants of Health Linked to Treatment-resistant Hypertension in Black Americans
DAIC
MAY 16, 2024
Getty Images milla1cf Thu, 05/16/2024 - 15:37 May 16, 2024 — People were more likely to develop a type of treatment-resistant hypertension when they experienced adverse effects of economic and social conditions that influence individual and group differences in health status, known as social determinants of health.
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RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial haploinsufficiency of RAB7 caused spontaneous pulmonary hypertension (PH) in mice. Here, we explored the role of RAB7 in endothelial cell (EC) function and lung vascular homeostasis.
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Current Therapeutic Guidelines for Managing Resistant Hypertension
HCPLive
DECEMBER 18, 2024
Panelists discuss how resistant hypertension management requires a structured approach combining lifestyle modifications, optimal doses of multiple drug classes, and the identification of underlying causes such as sleep apnea.
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Eating more fruits and vegetables to reduce dietary acid lowers blood pressure and improves kidney and heart health in patients with hypertension
Science Daily - Heart Disease
AUGUST 6, 2024
Doctors recommend making fruits and vegetables a foundational part of the treatment of patients with hypertension. Diets high in fruits and vegetables are found to lower blood pressure, reduce cardiovascular risk, and improve kidney health due to their base-producing effects.
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New therapy shows promise in treating hypertension-induced organ damage
Medical Xpress - Cardiology
JUNE 17, 2024
A team of researchers led by Monash University and the Baker Heart and Diabetes Institute have published the first compelling evidence of the therapeutic potential of a new therapy to treat hypertension-induced organ damage. The paper appears in the journal Cardiovascular Research.
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Hormone replacement therapy may improve pulmonary hypertension and right ventricular function
Medical Xpress - Cardiology
MAY 19, 2024
The use of hormone replacement therapy (HRT) may be associated with improved pulmonary hypertension in women, according to research presented at the ATS 2024 International Conference held May 17–22 in San Diego.
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Tenax Therapeutics Announces New U.S. Patent Covering the Use of Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
DAIC
MAY 6, 2024
Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,
Unique cell-based approach for pulmonary arterial hypertension shown to be safe
Science Daily - Heart Disease
DECEMBER 13, 2023
Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a new study.
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NYC Health + Hospitals receives 3rd award for hypertension care
Becker's Hospital Review - Cardiology
JUNE 6, 2024
NYC Health + Hospitals has for a third time received an award from HHS for its innovative hypertension care. The New York City public health system is one of 11 organizations in the nation to be recognized, according to a June 5 news release from the system.
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Renal Denervation for the Treatment of Hypertension: A Scientific Statement From the American Heart Association
Hypertension Journal
AUGUST 5, 2024
Hypertension, Ahead of Print. Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Most but not all of the new generation of trials reached their primary end point, demonstrating modest efficacy of renal denervation in lowering blood pressure across a spectrum of hypertension, from mild to truly resistant.
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Malignant hypertension: current challenges, prevention strategies, and future perspectives
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
IntroductionBased on office blood pressure (BP) values, hypertension is categorized into three stages: stage 1 (140159/9099mmHg), stage 2 (160179/100109mmHg), and stage 3 (180/110mmHg). At the same time, there are a number of alternatives available for treating MHT.
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