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Background Heart failure (HF) is a serious and common condition affecting millions of people worldwide, with obesity being a major cause of metabolic disorders such as diabetes and cardiovascular disease. In addition, we investigated the beneficial effects of fenofibrate on HF hospitalization. During the 4.22-year
In today’s society, the prevalence of obesity has become a significant concern. have obesity, and this rate has increased by more than 10 percentage points in the past two decades. Understanding the prevalence of obesity is crucial in comprehending why events like Healthy Weight Week are essential. of adults in the U.S.
Case presentation A 43-year-old man with a body mass index of 41 kg/m 2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy. We initiated a mobilization program, but the patient's mobility was highly limited due to severe obesity and symptomatic orthostatic hypotension.
Between 1999 and 2020, obesity-related deaths from heart disease deaths in the U.S. increased by 180%, according to a preliminary study to be presented at the American Heart Association's annual Scientific Sessions, set for Nov.
Previous studies have associated obesity with negative changes in the right ventricle using imaging techniques. However, the connection between obesity and more direct measures of right ventricle function, particularly those reflecting hemodynamic consequences, have been unclear. Original article: Circ Heart Fail. 2023;16:e010524.
mtaschetta-millane Wed, 07/31/2024 - 06:00 July 31, 2024 — A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute, demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF).
Background Aging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. Methods A total of 77 hospitalized patients (mean age 78.68 ± 9.65 Results The highest CAVI (11.31 ± 2.58) was found in sarcopenic patients.
Obesity, a pervasive health concern, has been identified as a significant risk factor for ATAAD, introducing unique surgical challenges that can influence postoperative outcomes. Based on BMI (WS/T 428-2013), patients were categorized into normal weight, overweight, and obese. Results The average age of the cohort was 50.1 ± 11.2
Background The obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). Methods We analyzed 1,556 medical records from the HF outpatient clinic of a quaternary hospital and 242 were selected according to the criteria.
Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease. Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well.
The retrospective analysis highlights improved outcomes among patients with obesity and a history of bariatric surgery hospitalized with decompensated cirrhosis.
22 in Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics. GLP-1s reduced mortality and complications from cardiovascular events, according to a study published Aug.
AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited.
Tirzepatide reduced the risk of heart failure hospitalization or cardiovascular death by 38% and improved body weight by up to 21% in the SUMMIT trial.
Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.
The role of obesity in RV dysfunction and adverse outcomes is unclear.METHODS:We examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. years of follow-up, we observed 3006 mortality and 2004 heart failure hospitalization events. Over median of 7.3 per 1-SD increase [95% CI, 1.04–1.18]),
Meanwhile, Metabolically healthy obesity (MHO) trends are understudied in association with stroke. Patients were categorized into a metabolically healthy obese MHO+ve cohort, BMI> 30, and MHO-ve cohort, BMI<30. Background:Obesity has been associated with an increase in the risk of stroke and poor outcomes.
Body mass index (BMI) ‘(weight (kg)/height (m) 2 ) was calculated and patients with BMI ≥30 kg/m 2 were categorised as obese. kg/m 2 and 23.2% (255) were categorised as obese. On multivariable analysis, obesity showed paradoxical protective effect with adjusted OR of 0.59 (95% CI 0.36 to 7.15, p=0.007).
Many patients with NVAF are obese and manage other health conditions requiring multiple medications. Allcause HRU rates were significantly lower with rivaroxaban versus warfarin, and hospital stays were reduced by 3.1 Journal of the American Heart Association, Ahead of Print. days with rivaroxaban.
Background:Metabolic syndrome and obesity are known to increase the incidence of lung cancer. We investigated the association between metabolic health and overweight/obesity phenotypes and clinical outcomes in patients with resectable non-small cell lung cancer (NSCLC).Methods:This 0.98, p = 0.040; MUO: adjusted HR 0.76, 95% CI 0.60-0.96,
Introduction:Rising obesity rates and the increasing prevalence of stroke in the metabolically healthy obese (MHO) necessitate examining its association in younger (18-44 year) populations. Most were hospitalized in southern US urban teaching hospitals.
"We're pleased to present the RELIEVE-HF data at this year's ACC meeting, as we continue to advance this important technology with the goal of bringing a much-needed treatment option to patients with advanced heart failure, a leading cause of death and hospitalization in the U.S. and worldwide," said Neal Eigler, M.D. , CEO of V-Wave.
We wanted to know if this survival benefit of multi-arterial grafting observed in single-center studies would translate to a large national cohort,” said the study’s lead author, Joseph Sabik III , MD, University Hospitals. The only patients where single arterial grafting resulted in better survival were severely obese,” said Dr. Sabik.
However, TTEs are not always readily available, can delay hospital discharge, and increase the cost of each hospitalization. Introduction:Determining ischemic stroke etiology using transthoracic echocardiography (TTE) is often considered to be a standard part of routine stroke care and secondary prevention of stroke.
2 Most are balancing multiple comorbidities, such as obesity, diabetes, hypertension and chronic kidney disease (CKD). A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients (REDEFINE-HF). 4 Approximately 6.7 million adults in the U.S. NCT 06008197.
Atrial fibrillation (AF) is responsible for significant patient morbidity, and obesity is a major contributor to AF incidence and symptom burden. This randomised study set out to examine if smartphone-based app technology could increase weight loss in a patient population with obesity and AF.
CI, confidence interval; CVD, cardiovascular disease; GLP-1 RA, glucagon-like peptide-1 receptor agonist; HHF, hospitalization for heart failure; HR, hazard ratio; NYHA, New York Heart Association. Obesity did not modify the effects of EQW on HHF. The risk of HHF was also modified by baseline NYHA class (HR 0.91, 95% CI 0.65–1.27
With deaths from obesity-related heart disease reportedly increasing by 180% over the past 20 years, more research is being done to learn how GLP-1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound can address outcomes in cardiovascular health.
Semaglutide treatment was found to reduce healthcare costs significantly for patients with overweight or obesity and who had either heart failure or atherosclerotic cardiovascular disease, according to studies presented Nov. 3-6 at the Obesity Society's annual Obesity Week conference and reviewed Nov.
Abstract Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations are lower in patients with obesity. Hospitalization for heart failure (HHF) was examined across strata of baseline BMI and NT-proBNP.
kg/m2), normal weight (18.524 kg/m2), overweight (2428 kg/m2), and obese (>28 kg/m2). Considering patients with 1 SMuRF and obesity as the reference group, the group who were SMuRFless underweight exhibited the highest increase in mortality (adjusted OR, 3.854 [95% CI, 2.1306.973],P<0.001).ConclusionsAmong
This observational study aims to investigate the association between income status in acute ischemic stroke (AIS) and cardiovascular events among young, hospitalized adults with dependent cannabis use or cannabis use disorder (CUD).Methods:We vs. 27.9%), visiting rural hospitals (13.9% vs. 12.7%), DM (8% vs. 6.6%), and obesity (10.9%
Lilly’s blockbuster GLP-1 tirzepatide appears poised to become the next major HFpEF drug, after topline results from the SUMMIT trial showed that it significantly improved both outcomes and symptoms among patients with heart failure with preserved ejection fraction and obesity. vs. +15 KCCQ-CSS points).
Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular disease risk factors cluster (histories of hyperlipidemia, obesity, anddiabetes, and family history of cardiovascular disease and smoking); (..)
The GLP-1 tirzepatide, the active ingredient in Eli Lilly's Mounjaro, was found to reduce the risk of heart failure by 46% among individuals with obesity, according to a study published Nov. 16 in The New England Journal of Medicine and presented at the American Heart Association's annual Scientific Sessions.
We present the case of a 28-year-old obese Caucasian male who arrived at our hospital with significant pain and swelling in his right lower extremity. Inferior vena cava (IVC) agenesis is a rare congenital anomaly that has been implicated in up to 5% of unprovoked deep vein thrombosis (DVT) cases in young men under 30 years old.
Our study focuses on addressing this gap by evaluating adherence to OMT, examining its influence on the risk of MACEs after STEMI, and assessing subsequent cardiovascular risk factor control in Mexico.MethodsWe conducted a prospective observational study of post-STEMI patients after hospital discharge. Patients were followed up for 4.5
This is supported by studies showing that ALAN exposure is associated with a range of conditions like cardiometabolic disease, obesity, and diabetes. How could ALAN and the SCN affect cardiovascular health? Three main pathways predominate: melatonin release, the autonomic nervous system, and the endocrine (hormonal) system.
Optimal NT-proBNP cut points for HFpEF rule out (optimizing sensitivity) and rule in (optimizing specificity) were derived and tested, stratified by obesity and atrial fibrillation. In our study, NT-proBNP provided little value in those with AF and dyspnea because the presence of AF is by itself a robust biomarker of HFpEF.
Sodium/glucose cotransporter 2 (SGLT2) inhibitors are a novel class of anti-diabetic medications which have proved capable of providing breakthrough cardiovascular benefits in a variety of clinical scenarios, including patients with heart failure or obesity, irrespective of diabetic status.
Hospital readmission rates can help identify the optimal strategy to minimize post-procedural complications. The purpose of this study is to analyze 30-day readmission rates in elective and nonelective CAS and CEA procedures.Methodology:The 2017 National Readmission Database is queried for hospital admissions for CAS and CEA procedures.
We aimed to compare in-hospital mortality and predictors in stroke patients with secondary rheumatological conditions.Methods:Using the National Inpatient Sample (NIS), we identified patients ≥18 admitted for stroke (Jan 2019 - Dec 2020), stratified into RA, SLE, scleroderma, or vasculitides groups using ICD-10-CM codes.
Except in the setting of type 2 diabetes, metabolic syndrome, insulin resistance and obesity. Using LDL cholesterol to guide your decisions is ok but not great. Usually LDL -C roughly equates to levels of ApoB. But My Doctor Doesn’t Test For ApoB. No problem. You have two options.
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