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Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta?Analysis

Journal of the American Heart Association

BackgroundIntravenous thrombolysis (IVT) is an effective stroke therapy that remains underused. Outcomes included symptomatic intracranial hemorrhage, any intracranial hemorrhage, serious systemic bleeding, and 90‐day functional independence (modified Rankin scale score 0–2). The rates of symptomatic intracranial hemorrhage (3.4

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SHINE Trial Sheds Light on Deadly Stroke Complication

DAIC

The new analysis of the trial results, led by UVA Health’s Andrew Southerland , MD, found that high blood sugar shortly after thrombolysis – opening blocked arteries in the brain with a clot-busting drug – was associated with greater risk for potentially deadly brain bleeds, particularly in older patients with more severe strokes.

Strokes 105
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Abstract DP4: When Does Clinical Worsening Begin in Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis?

Stroke Journal

Introduction:Intravenous thrombolysis with alteplase (tPA) or tenecteplase (TNK) is a first-line treatment for acute ischemic stroke. The most serious risk associated with IV thrombolytics is symptomatic intracranial hemorrhage (sICH). sICH was defined as a hemorrhage that caused an increase in NIHSS by 4 or more points.

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Abstract TP8: Prolonged Low-Dose Intravenous Thrombolysis in early recurrent Stroke: ESR-PROLONG Study

Stroke Journal

The safety of the treatment was evaluated based on the occurrence of any complications, the occurrence of intracerebral hemorrhage, and the occurrence of symptomatic intracerebral hemorrhage (assessed according to SITS-MOST criteria).Results:44 The incidence of intracerebral hemorrhage was 9.1% men, average age 71.512.2

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Abstract WP1: Intravenous Thrombolysis for Central Retinal Artery Occlusion in Routine Clinical Practice

Stroke Journal

One of the considered and currently increasingly preferred options is intravenous thrombolysis. Overall, intracerebral hemorrhage occurred in 6.3%. One patient had vitreous hemorrhage with subsequent correction of vision.Conclusion:CRAO is a significantly neglected subgroup of ischemic stroke.

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Abstract WP20: Hemorrhagic Conversion Patterns After Stroke Thrombolysis With Alteplase versus Tenecteplase Real-World Experience

Stroke Journal

Secondary endpoint included the radiographic pattern of hemorrhagic conversion according to the Heidelberg bleeding classification (HBC).Results:Median Suggested mechanisms of bleeding are hemorrhagic conversion in clinically silent infarcts and contusions underlying the lesions. Results:Median age was 62.94 for alteplase and 64.45

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Abstract TP25: Benefits and Risks of Antiplatelet Versus Thrombolysis for Mild Acute Ischemic Stroke: Update of a Living Systematic Review and Meta-analysis

Stroke Journal

Background:Previous study found that compared with thrombolysis, antiplatelet did not improve outcomes but reduce the risk of symptomatic intracranial hemorrhage(sICH) for mild acute ischemic stroke(AIS) defined as National Institutes of Health Stroke Scale score 0 to 5. to 1.35]; mRS 0-2, odds ratio, 1.06 [95% CI, 0.73