Stroke Journal

FEBRUARY 5, 2024

Stroke, Ahead of Print. BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. 0.98]), a numerically higher incidence of symptomatic intracerebral hemorrhage (6.7% mg/kg alteplase).METHODS:We mg/kg alteplase).METHODS:We

Thrombolysis 75

Thrombolysis Hemorrhage Atrial Fibrillation Strokes 75

Stroke Journal

MARCH 8, 2024

Stroke, Ahead of Print. Background:Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non–wake-up unwitnessed stroke, non-WUS). Death occurred in 4.0% and 0.3%, respectively (P=0.194).

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP25-ATP25, February 1, 2025. Background:Previous study found that compared with thrombolysis, antiplatelet did not improve outcomes but reduce the risk of symptomatic intracranial hemorrhage(sICH) for mild acute ischemic stroke(AIS) defined as National Institutes of Health Stroke Scale score 0 to 5.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP11-AWP11, February 1, 2025. Introduction:Stroke is a leading cause of disability and mortality worldwide, with thrombolysis as a critical treatment. Studies aiming to assess the outcomes of thrombolysis after ischemic stroke in LMIC were selected.

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP3-ADP3, February 1, 2025. Background:Current guidelines for ischemic stroke recommend initiating intravenous thrombolytic therapy within 4.5 hours after stroke onset or the last known well time. These modalities can identify viable brain tissue beyond the 4.5-hour h to standard of care.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP1-ADP1, February 1, 2025. Background:Cerebral amyloid angiopathy (CAA) is a hemorrhagic cerebrovascular disease that is thought to be due to excess protein deposition in vessel walls that lead to fragility and increase the risk of rupture. to 5.75], p<0.001), and SAH (aOR 2.42 [95%CI 1.41-4.16],

Thrombolysis 40

Thrombolysis Strokes Stroke Cerebrovascular Disease 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A59-A59, February 1, 2024. Introduction:Many patients are taking antiplatelet medications when an acute stroke occurs. The exposure of interest was pre-stroke antiplatelet use categorized as none, single (SAPT), and dual antiplatelet therapy (DAPT). no antiplatelet, 36.7% SAPT, and 6.4%

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionImportance:Tenecteplase (TNK) use is more prevalent as the thrombolytic drug of choice for acute ischemic stroke (AIS), given its ease of use with results from randomized trials showing non‐ inferiority and comparable safety to Alteplase (tPA).

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIntravenous thrombolytics (IVT) and mechanical thrombectomy (MT) have become the standards of care for treating patients with large vessel occlusion (LVO) acute ischemic strokes (AIS) [1‐4}. in a large multicentered meta‐analysis [2,6].

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A4-A4, February 1, 2025. Introduction:The tenecteplase versus standard of care for minor ischemic stroke with proven occlusion (TEMPO-2) trial showed that patients presenting with minor deficits up to 12 h do not benefit from intravenous thrombolysis. vs control 2.1%, P=0.005.

Thrombolysis 40

Thrombolysis Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP1-AWP1, February 1, 2025. Background and aims:Central retinal artery occlusion (CRAO) is a rare but significantly underestimated form of ischemic stroke. One of the considered and currently increasingly preferred options is intravenous thrombolysis. years, 46.9%

Thrombolysis 40

Thrombolysis Hemorrhage Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP9-AWP9, February 1, 2025. Background:Acute ischemic stroke can result from extracranial arterial dissection. The effectiveness and safety of intravenous thrombolysis (IVT) for acute ischemic stroke in these cases, particularly those involving large vessel occlusions, are debated.

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP20-ATP20, February 1, 2025. The primary outcome was 3-month functional outcome by modified Rankin scale (mRS). Patients with elevated traditional risk factors at admission may benefit more from thrombolytic therapy compared to those with high inflammatory response indicators.

Thrombolysis 40

Thrombolysis Strokes Stroke Risk Factors 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP78-AWMP78, February 1, 2024. Introduction:Mobile stroke units (MSUs) are an evolving means to expedited acute stroke management. The target blood pressure goal was met much quicker in the MSU. Faster time metrics convey a hypothetical benefit towards improved patient outcomes.

Hemorrhage 40

Hemorrhage Blood Pressure Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.

Thrombolysis 40

Thrombolysis Strokes Stroke Stent 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2025. Introduction:Current guidelines recommend 24-hours of high-intensity monitoring (HIM) for acute ischemic stroke patients post-intravenous thrombolysis (IVT) due to risk of bleeding complications including symptomatic intracranial hemorrhage (sICH).

Thrombolysis 40

Thrombolysis ICU Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP11-ATP11, February 1, 2025. Introduction:Current guidelines suggest using intravenous thrombolysis (IVT) for patients experiencing acute ischemic stroke within 4.5 The safety outcome was the rate of symptomatic intracranial hemorrhage (SICH).Results:We hours of symptom onset.

Thrombolysis 40

Thrombolysis Strokes Stroke Education 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP72-AWMP72, February 1, 2025. Introduction:Emerging technologies, such as Cone-Beam CT (CBCT), may improve workflows in acute ischemic stroke (AIS). Conclusion:CBCT had high specificity for ICH and hemorrhage types.

Hemorrhage 40

Hemorrhage Strokes Stroke Thrombolysis 40

Stroke Journal

JANUARY 4, 2024

Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Although symptomatic intracranial hemorrhages occurred more often in the IVT group (4.8%

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Ischemia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. Background:Patients with acute ischemic stroke and a large vessel occlusion (LVO) admitted to primary stroke centers (PSC) often require inter-facility transfer for thrombectomy.

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A30-A30, February 1, 2025. Background and objective:Perfusion imaging studies consistently show a substantially increased risk of hemorrhagic transformation (HT) in severely hypoperfused tissue.

Hemorrhage 40

Hemorrhage Strokes Stroke Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024. Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2).

Thrombolysis 40

Thrombolysis Strokes Stroke Hemorrhage 40

ADN Center of Excellence

OCTOBER 28, 2024

On October 29th, the global community observes World Stroke Day , an occasion dedicated to raising awareness about one of the most formidable threats to global health: stroke. Often called the "silent killer," stroke is a leading cause of death and disability worldwide.

Strokes 59

Strokes Stroke Education Innovation 59

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP222-AWP222, February 1, 2025. Background and Aims:Machine learning models have shown promising potential for automated hemorrhage detection and segmentation, alleviating highly time-consuming manual contouring and facilitating rapid clinical diagnosis. 93.7%) and accuracy of 87.4%

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP9-ATP9, February 1, 2025. Introduction:Tenecteplase (TNK) is now an accepted alternative to Alteplase (ALT) for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Time to IVT was grouped as ultra-early (0-90 min), early (91-180 min), and late (181-270 min).

Hemorrhage 40

Hemorrhage Diabetes Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stent 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP242-ATP242, February 1, 2025. Background:Symptomatic intracranial hemorrhage (sICH) is the most dreaded complication after reperfusion therapy for acute ischemic stroke. 2.07; P = 0.037). 2.07; P = 0.037). Risk of sICH was comparable between the MT and MT+IVT groups (RR: 0.77; 95%CI: 0.57-1.03;

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP245-AWP245, February 1, 2025. Background and Aims:Previous studies indicated the usual dose heparin(5000 IU bolus followed by 500~1250 IU/h) during mechanical thrombectomy(MT) is associated with an increased risk of hemorrhagic conversion without beneficial effect. vs 21.3%, p=0.04).

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP177-AWP177, February 1, 2024. Definitions of symptomatic HT developed during the intravenous thrombolysis (IVT) era are outdated in the endovascular thrombectomy (EVT) era but continue to be widely used. Background:Hemorrhagic transformation (HT) is the principal adverse event of thrombectomy.

Hemorrhage 40

Hemorrhage Outcomes Thrombolysis Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP190-ATP190, February 1, 2025. Background:The prognostic significance of the affected hemisphere in hemorrhagic stroke remains uncertain. The association of ICH laterality with clinical outcomes was estimated using multiple linear regression models.

Quality of Life 40

Quality of Life Hemorrhage Outcomes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP202-AWP202, February 1, 2024. Background:Mechanical thrombectomy (MT) has demonstrated superiority over medical therapy for acute ischemic stroke (AIS) with large vessel occlusion (LVO).

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP63-ATMP63, February 1, 2024. Background:The American Heart Association guidelines recommend BP goal of <180/105 mmHg for the first 24 hours in acute ischemic stroke (AIS) patients treated with IV Alteplase and now adopted for IV Tenecteplase (TNK). vs 4.9%; p=0.3) vs 1.4%; p=0.2).Conclusion:Our

Hemorrhage 40

Hemorrhage Blood Pressure Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2024. Background:Prior studies have shown that individuals who have an in-hospital stroke are less likely to receive thrombolysis. Out of hospital strokes were patients who were not admitted to the hospital when their stroke symptoms.

Hospital 40

Hospital Strokes Stroke Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP225-AWP225, February 1, 2025. Background:Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are the standard of care for select stroke patients with acute large vessel occlusion (LVO).

Hemorrhage 40

Hemorrhage Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP154-AWP154, February 1, 2024. Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% vs. 6.1%, p = 0.0326), and symptomatic intracerebral hemorrhage (7.3% vs. 1.9%, p = 0.0109). p = 0.0157).Conclusions:Almost

ICU 40

ICU Thrombolysis Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP179-AWP179, February 1, 2024. Background:Stent-retriever thrombectomy is the first-line therapy for acute stroke with intracranial large vessel occlusion. In cases of stent-retriever thrombectomy failure, rescue stent angioplasty might be the sole option for achieving permanent recanalization.

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP72-AWP72, February 1, 2025. Background:Our system, comprised of 21 Northeast Ohio hospitals includes 3 Stroke Ready, 10 Primary and 1 Comprehensive Stroke Center (CSC). Clinical trials support the efficacy and safety of Tenecteplase for the treatment of acute ischemic stroke (AIS).

Strokes 40

Strokes Stroke Thrombolysis Nursing 40