Stroke Journal

JANUARY 4, 2024

Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. Although symptomatic intracranial hemorrhages occurred more often in the IVT group (4.8%

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A25-A25, February 1, 2024. Introduction:Intravenous thrombolysis (IVT) is efficacious treatment of acute ischemic stroke (AIS). Outcomes of interest were symptomatic intracranial hemorrhage (sICH), any ICH, serious systemic bleeding (SSB), and 90-day functional independence (mRS 0-2).

Thrombolysis 40

Thrombolysis Stroke Strokes Hemorrhage 40

Stroke Journal

FEBRUARY 5, 2024

Stroke, Ahead of Print. BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. 0.98]), a numerically higher incidence of symptomatic intracerebral hemorrhage (6.7% mg/kg alteplase).METHODS:We mg/kg alteplase).METHODS:We

Thrombolysis 75

Thrombolysis Hemorrhage Atrial Fibrillation Stroke 75

DAIC

FEBRUARY 7, 2024

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. A lot of our approaches in stroke treatment were learned from how we treat heart attacks.

Stroke 105

Stroke Strokes Outcomes Thrombolysis 105

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP202-AWP202, February 1, 2024. Background:Mechanical thrombectomy (MT) has demonstrated superiority over medical therapy for acute ischemic stroke (AIS) with large vessel occlusion (LVO).

Thrombolysis 40

Thrombolysis Academic Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP63-ATMP63, February 1, 2024. Background:The American Heart Association guidelines recommend BP goal of <180/105 mmHg for the first 24 hours in acute ischemic stroke (AIS) patients treated with IV Alteplase and now adopted for IV Tenecteplase (TNK). vs 4.9%; p=0.3) vs 1.4%; p=0.2).Conclusion:Our

Hemorrhage 40

Hemorrhage Blood Pressure Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis 40

Thrombolysis Outcomes Embolism Stents 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP42-AWMP42, February 1, 2024. Background:Prior studies have shown that individuals who have an in-hospital stroke are less likely to receive thrombolysis. Out of hospital strokes were patients who were not admitted to the hospital when their stroke symptoms.

Hospital 40

Hospital Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP154-AWP154, February 1, 2024. Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% vs. 6.1%, p = 0.0326), and symptomatic intracerebral hemorrhage (7.3% vs. 1.9%, p = 0.0109). p = 0.0157).Conclusions:Almost

ICU 40

ICU Thrombolysis Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP179-AWP179, February 1, 2024. Background:Stent-retriever thrombectomy is the first-line therapy for acute stroke with intracranial large vessel occlusion. In cases of stent-retriever thrombectomy failure, rescue stent angioplasty might be the sole option for achieving permanent recanalization.

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP146-ATP146, February 1, 2024. Introduction:Collateral status imaging parameters are associated with predicting hemorrhagic transformation (HT) in acute ischemic stroke caused by large vessel occlusions. p=0.006); CBV index (aOR 0.0002, 95% CI 0-0.1,

Hemorrhage 40

Hemorrhage Thrombolysis Diabetes Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP21-AWP21, February 1, 2024. Introduction:Although prior antiplatelet therapy (APT) could potentially contribute to bleeding risk, the influence of prior APT on intravenous thrombolysis outcomes remains controversial. Of these, 257 (32.9%) patients were receiving prior APT.

Stroke 40

Stroke Strokes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP86-ATMP86, February 1, 2024. Introduction:Tenecteplase improves reperfusion and functional outcomes in stroke patients with large vessel occlusion. Primary safety outcome was parenchymal hematoma type 2 (PH2) intracerebral hemorrhage. Mean age was 68, and 50.0% were females.

Stroke 40

Stroke Strokes Thrombolysis Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP282-ATP282, February 1, 2024. Background:This analysis is based on a prospective database encompassing consecutive patients who underwent EVT for LVO between January 2021 and June 2023 at a comprehensive stroke center (CSC).Main vs. 70.6 ± 14.5). min vs. 394.5 min vs. 45.1 hours vs. 59.3

Stroke 40

Stroke Strokes Thrombolysis ICU 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP8-AWP8, February 1, 2024. Median time from the onset of visual change to thrombolysis was 6.0 [4.5-10.5] Introduction:Branch retinal artery occlusion (BRAO) results from the blood flow compromise in of the branches of the central retinal artery. VA improvement of ≥0.1 VA improvement of ≥0.1

Thrombolysis 40

Thrombolysis Outcomes Hemorrhage Stroke 40

Stroke Journal

DECEMBER 21, 2023

Stroke, Volume 55, Issue 1 , Page 78-88, January 1, 2024. BACKGROUND:The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. 1.99]; aOR, 1.63 [95% CI, 1.14–2.32], 2.32], respectively).

COVID-19 40

COVID-19 Outcomes Stroke Strokes 40

Journal of the American Heart Association

JANUARY 31, 2024

BackgroundPrevious clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake‐up stroke (WUS) selected by advanced imaging techniques. Thrombolytic treatment in WUS versus known‐onset stroke was compared in 730 patients (365 matched pairs). of patients with known‐onset stroke (OR, 1.14 [95% CI, 0.54–2.41];P=0.726).ConclusionsThrombolytic

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

MARCH 11, 2024

Stroke, Ahead of Print. Background:The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. Results:A total of 20 high-quality studies, comprised of 13 397 patients with acute minor ischemic stroke, were included.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP5-AWP5, February 1, 2024. Background:Diabetes mellitus (DM) is one of the risk factors for acute ischemic stroke, usually leading to poor prognosis. While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients.

Diabetes 40

Diabetes Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP215-AWP215, February 1, 2024. Introduction:Acute ischemic stroke (AIS) patients often require multiple passes during mechanical thrombectomy (MT) to open the vessel. Secondary outcomes included any intracranial hemorrhage (ICH) and symptomatic ICH (sICH).

Stroke 40

Stroke Strokes Thrombolysis Aneurysm 40

Stroke: Vascular and Interventional Neurology

JANUARY 31, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDPrior studies have shown benefit for endovascular therapy (EVT) in patients with large‐vessel occlusion and severe deficits, as captured by the National Institutes of Health Stroke Scale (NIHSS).

Inpatient 40

Inpatient Circulation Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionBackground: Patients with acute strokes with large infarct size are traditionally excluded from endovascular therapies, as like as clinical care. 1.98], p: 0.03). 1.84]), or those 75 or older than 75 years old (RR: 1.43, 95% CI: [1.12‐1.84]),

Stroke 40

Stroke Strokes Thrombolysis Hemorrhage 40

Stroke Journal

DECEMBER 28, 2023

Stroke, Ahead of Print. We aimed to determine the safety dose range of reteplase for patients with acute ischemic stroke within 4.5 The primary safety outcome was symptomatic intracranial hemorrhage (SITS definition) within 36 hours. Four patients did not receive the study agent.

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2024. Outcomes included sICH, and inpatient mortality, adjusted for confounders which included age, gender, baseline NIHSS, perfusion grade (TICI) intravenous thrombolysis, history of diabetes and HBA1c.Results:A total of 224 patients (mean age was 68.7 years (±14.3); 44.2%

Inpatient 40

Inpatient Stroke Strokes Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP146-AWP146, February 1, 2024. Introduction:Intravenous thrombolytic therapy remains the cornerstone of management in acute ischemic stroke (AIS) patients.

ICU 40

ICU Critical Care Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 21, 2023

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDAs the number of thrombectomy passes increases during endovascular therapy (EVT) for acute stroke, neurointerventionalists must weigh the risks of potential complications against the risk of failing to recanalize the affected vessel. 60.3]; and 5.26 [1.12–24.8],

Outcomes 40

Outcomes Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

OCTOBER 2, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue 6 , November 1, 2023. BackgroundSoutheast Asia accounts for approximately 10% of stroke‐related mortalities worldwide, yet there are limited data regarding mechanical thrombectomy (MT) outcomes in this region. range 0–10). Mean puncture‐to‐revascularization time was 53.3±53.9

Stroke 40

Stroke Strokes Hemorrhage Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP193-ATP193, February 1, 2024. Successful recanalization was defined as modified Thrombolysis in Cerebral Ischemia Score≥ 2b. Secondary outcomes were symptomatic intracranial hemorrhage and intracranial hemorrhage within 24 hours and mortality at 90 days.

Outcomes 40

Outcomes Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPosterior circulation strokes account for 20% of ischemic strokes (1). Optimal management for posterior circulation strokes has been studied less than for anterior circulation strokes (2). hours prior to arrival.

Stroke 40

Stroke Strokes Embolism Hemorrhage 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP288-AWP288, February 1, 2024. Results:Between 2017 and 2022, 1,283,435 CVD cases were notified (SAH=4,7%; ICH= 8.8%; and ischemic stroke=86.5%). Results:Between 2017 and 2022, 1,283,435 CVD cases were notified (SAH=4,7%; ICH= 8.8%; and ischemic stroke=86.5%). were Male and 47.6%

Cerebrovascular Disease 40

Cerebrovascular Disease Thrombolysis Hemorrhage Public Health 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP192-AWP192, February 1, 2024. Introduction:Despite comparable outcomes for different frontline techniques in mechanical thrombectomy (MT) for acute ischemic stroke (AIS), there are sparse data regarding if and when to switch techniques if the first pass is unsuccessful.

Circulation 40

Circulation Stroke Strokes Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Primary outcome was defined as favorable 90-day outcome (modified Rankin Scale (mRS) score 0-2).

Dementia 40

Dementia Outcomes Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP191-AWP191, February 1, 2024. Introduction:The mantra ‘time is brain’ cannot be overstated for patients suffering from acute ischemic stroke. The median NIHSS was 16 (10-20), 50% were treated with intravenous thrombolysis at a spoke, and TICI 2B-3 reperfusion was achieved in 87% at the hub.

Stroke 40

Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe mantra ‘time is brain’ cannot be overstated for patients suffering from acute ischemic stroke. The median age was 67 (IQR 57‐80), and 46% were female. The median DIDO was 120 min (97‐149), with DIDO ≤90 min achieved in 18%.

Stroke 40

Stroke Strokes Thrombolysis Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIntracranial atherosclerotic disease (ICAD) is associated with up to 32% of posterior circulation strokes.1 1 ICAD‐related strokes are at high risk for re‐occlusion following MT.

Stent 40

Stent Stents Circulation Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP76-AWP76, February 1, 2024. This is concerning, especially given the potential benefits for specific patient populations like African Americans and hypertensives who may have higher needs for stroke monitoring. 25.5), hypercholesterolemia(1.8,

Ultrasound 40

Ultrasound Stroke Strokes Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A28-A28, February 1, 2024. Introduction:ACTIMIS (NCT03803007) was a randomized phase 1b/2a clinical trial evaluating glenzocimab, a monoclonal antibody fragment targeting platelet receptor glycoprotein VI in patients with acute ischemic stroke treated by thrombolysis.

Hemorrhage 40

Hemorrhage Thrombolysis Biomarkers Stroke 40