Stroke Journal

FEBRUARY 1, 2024

Introduction:Elevated levels of Interleukin-6 (IL-6) levels in cerebrospinal fluid (CSF) have been correlated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Further studies are needed to validate findings and refine MAP management for improved outcomes in aSAH patients.

Aneurysm 40

Aneurysm Hemorrhage Ischemia Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Real-world data showed that less than half of the acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) presenting with low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) (2-5) achieved favorable outcomes at 90 days after mechanical thrombectomy (MT). was related to 90-day mRS 0-3.

Outcomes 40

Outcomes Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 15, 2024

We aimed to compare the clinical and radiological outcomes between WEB and BAC in a cohort of patients with ruptured wide‐necked intracranial aneurysms.METHODSIn this international multicenter cohort study, we included consecutive patients treated for ruptured wide‐neck intracranial aneurysms with either WEB or BAC at 4 neurovascular centers.

Aneurysm 40

Aneurysm Outcomes Hemorrhage Stents 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

The aim of this study is to provide outcome comparisons between WEB and BAC in a specific cohort of patients with ruptured wide‐necked IAs.MethodsIn this international cohort study, we included consecutive patients treated for ruptured wide‐neck IAs with either WEB or BAC at three neurovascular centers. Of the patients, 60.5%

Aneurysm 40

Aneurysm Outcomes Hemorrhage Stents 40

Journal of the American Heart Association

JANUARY 31, 2024

This study compared outcomes for patients with DOAC treatment failure who changed or retained their prestroke DOAC.Methods and ResultsThis retrospective cohort study analyzed data from the National Health Insurance Research Database from 2012 to 2020. The primary outcome was a composite of recurrent IS and transient ischemic attack.

Atrial Fibrillation 40

Atrial Fibrillation Stroke Strokes Hemorrhage 40

Stroke Journal

JANUARY 4, 2024

Primary outcome was a shift toward better functional outcome on the modified Rankin Scale at 90 days. Although symptomatic intracranial hemorrhages occurred more often in the IVT group (4.8% These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included.

Thrombolysis 40

Thrombolysis Circulation Hemorrhage Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

In this study, we tested the hypothesis that small extracellular vesicles (sEVs) derived from healthy human VSMCs (VSMC-sEVs) reduce diabetes- and ischemia-neurovascular damage.Methods and Results:VSMC-sEVs were characterized.

Diabetes 40

Diabetes Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Despite comparable outcomes for different frontline techniques in mechanical thrombectomy (MT) for acute ischemic stroke (AIS), there are sparse data regarding if and when to switch techniques if the first pass is unsuccessful. 3.86, P = 0.002) and 90-day good clinical outcome (adjusted odds ratio 2.10, 95% CI: 1.15-3.85,

Circulation 40

Circulation Stroke Strokes Thrombolysis 40

Stroke: Vascular and Interventional Neurology

JANUARY 26, 2024

BACKGROUNDSteroids have pleiotropic neuroprotective actions including the regulation of inflammation and apoptosis which may influence the effects of ischemia on neurons, glial cells, and blood vessels. Secondary outcomes include 90‐day functional independence (modified Rankin scale score, 0–2).

Circulation 40

Circulation Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

MCA tortuosity was calculated using Inflection Count Metric(ICM) by two blinded readers to angiographical/clinical outcomes. The primary efficacy end point was achievement of modified Thrombolysis in Cerebral Ischemia (mTICI) reperfusion scores of ≥2b on first pass. Good functional outcomes was defined as mRS0-2 on 90-day followup.

Atrial Fibrillation 40

Atrial Fibrillation Thrombolysis Ischemia Stroke 40

Stroke Journal

FEBRUARY 1, 2024

intraluminal floating thrombus, intracardiac thrombus, acute coronary syndrome, acute limb ischemia, DVT and PE) within 3 days of symptom onset. The primary outcome was the incidence of intracranial hemorrhage (ICH) between both groups. The primary outcome was the incidence of intracranial hemorrhage (ICH) between both groups.

Atrial Fibrillation 40

Atrial Fibrillation Stroke Strokes Ischemia 40

Stroke Journal

FEBRUARY 1, 2024

The protective effect of NO donors has been shown to prevent ischemia-reperfusion injury through reduction of reactive oxygen species formation in cardiovascular studies. Eligible patients were randomized to receive 800μg GTN or same volume of normal saline through the catheter after recanalization.

Stroke 40

Stroke Strokes Ischemia Hemorrhage 40

Dr. Smith's ECG Blog

DECEMBER 26, 2020

Side note: The differential of sudden persistent loss of consciousness with adequate hemodynamics is relatively short: seizure, intracranial hemorrhage, basilar artery occlusion. We have also shown several cases in which atrial flutter hides true, active ischemia. There was again no intracranial hemorrhage.

Atrial Flutter 52

Atrial Flutter Ischemia STEMI Tachycardia 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

2,3The SAMMPRIS trial reported that percutaneous transluminal angioplasty and stenting (PTAS) was associated with inferior outcomes compared to aggressive medical management alone but it is unclear whether these findings are generalizable to LVO strokes.4 However, these rescue treatments are associated with their own risks.2,3The

Stent 40

Stent Stents Circulation Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionPituitary apoplexy is a serious, emergent, and potentially dangerous condition of the pituitary in which the gland is affected by hemorrhage and/or ischemia typically in the setting of an underlying adenoma. Rutkowski’s 2017 study was the only to assess outcomes prior to versus after intervention at the 72 hours timepoint.

Outcomes 40

Outcomes Ischemia Hemorrhage Stroke 40

Dr. Smith's ECG Blog

NOVEMBER 4, 2022

His response: “subendocardial ischemia. Smith : It should be noted that, in subendocardial ischemia, in contrast to OMI, absence of wall motion abnormality is common. With the history of Afib, CTA abdomen was ordered to r/o mesenteric ischemia vs ischemic colitis vs small bowel obstruction. Anything more on history?

Ischemia 52

Ischemia STEMI Stenosis Coronary Artery Disease 52

Stroke Journal

FEBRUARY 1, 2024

Background:Ischemia on diffusion weighted imaging (DWI) after intracerebral hemorrhage (ICH) increases the risk of future ischemic stroke. Though cortical superficial siderosis (cSS) is also a hemorrhagic small vessel disease subtype, it is unclear if cSS similarly relates to DWI lesions. and cSS in 10.6%.

Hemorrhage 40

Hemorrhage Ischemia Blood Pressure Stroke 40

Dr. Smith's ECG Blog

AUGUST 9, 2024

Opioids associate with worse outcomes in myocardial infarction , probably because they eliminate the pain signal that informs the clinician of the urgency of revascularization. below) Other examples of AIVR: Young man with Gunshot wound to right chest with hemorrhagic shock, but bullet path not near heart. Do not treat AIVR.

Chest Pain 88

Chest Pain Arrhythmia Myocardial Infarction STEMI 88

Stroke Journal

FEBRUARY 1, 2024

Background:Ischemic lesions on diffusion weighted imaging (DWI) occur in one-third of intracerebral hemorrhage (ICH). Patients with severe, chronic hypertension may be more vulnerable to the development of ischemia after ICH due to altered cerebral autoregulatory limits. and LVH was seen in 23.5%.

Hemorrhage 40

Hemorrhage Blood Pressure Hypertension Biomarkers 40

Stroke Journal

FEBRUARY 1, 2024

Introduction:Subarachnoid hemorrhage (SAH) following mechanical thrombectomy (MT) is not uncommon. Additionally, non-diffuse SAH group were significantly associated with significantly improved 90-day good functional outcomes defined as mRS 0-2 in unadjusted analysis (80% vs. 30%, OR 9.33, 95% CI 1.99-72.99, 102.05, p = 0.02).

Hemorrhage 40

Hemorrhage Outcomes Stents Stent 40

Dr. Smith's ECG Blog

FEBRUARY 6, 2024

The ECG shows sinus tachycardia with RBBB and LAFB, without clear additional superimposed signs of ischemia. Massive Transfusion for Motorcycle Collision with Hemorrhage, Troponin Elevated. Atrial fibrillation is also a predictor of worse outcomes in this case (Alborzi). Chest trauma was suspected on initial exam.

Tachycardia 109

Tachycardia Dysrhythmia Atrial Fibrillation Bradycardia 109

Stroke Journal

FEBRUARY 1, 2024

Background:We have previously identified that hemoglobin decrements and new-onset anemia during an intracerebral hemorrhage (ICH) hospitalization is frequent, rapid, and associates with poor outcome. Patients who had a brain MRI and serial hemoglobin measurements were included.

Hemorrhage 40

Hemorrhage Blood Pressure Ischemia Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Background:We identified that major ABO incompatible platelet transfusions are associated with poor intracerebral hemorrhage (ICH) outcomes, yet the driver for this relationship is unknown and does not appear to be related to impaired hemostasis. Conversely, acute ICH patients are known to develop remote ischemic lesions on brain MRI.

Hemorrhage 40

Hemorrhage Risk Factors Ischemia Outcomes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

With the evolving technology and newer generation of catheters and devices, the interest in improving the technical and procedural factors that can help better the recanalization success, clinical outcomes, and efficiency is ever‐growing. Most of the patients had MCA occlusion (68.4% with 50.9% 12) at discharge (Table).

Thrombolysis 40

Thrombolysis Ischemia Hemorrhage Stroke 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 5, 2024

Its characteristic cycle of ischemia, angiogenesis, and aberrant perfusion can lead to abnormal blood flow patterns that characterize the disease. Eleven patients experienced intracranial hemorrhage as a complication of CPA; 10 of the 11 patients underwent decompressive craniectomy.

Embolism 40

Embolism Ischemia Hemorrhage Stroke 40

Dr. Smith's ECG Blog

AUGUST 9, 2019

Post by Smith and Meyers Sam Ghali ( [link] ) just asked me (Smith): "Steve, do left main coronary artery *occlusions* (actual ones with transmural ischemia) have ST Depression or ST Elevation in aVR?" That said, complete LM occlusion would be expected to have subepicardial ischemia (STE) in these myocardial territories: STE vector 1.

Myocardial Infarction 52

Myocardial Infarction Ischemia STEMI Cardiogenic Shock 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

The primary outcome was successful reperfusion defined as a Modified Treatment in Cerebral Ischemia (mTICI) score of 2b or greater at the end of the procedure. Secondary outcomes included NIH Stroke Scale (NIHSS) at 24 hours, NIHSS at discharge, median modified Rankin Scale (mRS) score at discharge and at 90‐day follow‐up.

Angioplasty 40

Angioplasty Stents Stent Stroke 40

Dr. Smith's ECG Blog

APRIL 8, 2015

Also consider non-hemorrhagic volume depletion, dehydration : orthostatic vitals may uncover this [see Mendu et al. (3)]. Cardiac Syncope ("True Syncope") Independent Predictors of Adverse Outcomes condensed from multiple studies 1. Evidence of acute ischemia (may be subtle) vii. Abnormal ECG – looks for cardiac syncope.

Arrhythmia 52

Arrhythmia Outcomes Risk Factors Chest Pain 52