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BACKGROUND:It is unknown whether hypertensive microangiopathy or cerebral amyloid angiopathy (CAA) predisposes more to anticoagulant-associated intracerebral hemorrhage (AA-ICH). Among patients with AA-ICH, there were no differences in the proportion with lobar hemorrhage (63/148 [42.6%] versus 46/107 [43.0%]; OR, 1.02 [95% CI, 0.62–1.68];P=0.946)
Despite advances in surgical and percutaneous interventions, hypertension remains a significant complication in AoC patients, even after successful repair. Chronic hypertension develops in 20%70% of patients and is a leading cause of long-term cardiovascular morbidity.
Background:Local angiotensin activity is thought to play a critical role in arterial wall homeostasis and remodeling, which contributes to the pathogenesis of subarachnoid hemorrhage (SAH). million patients with hypertension were assessed. million patients with hypertension were assessed. million,follow-up:6.3 female) [HR:0.94(0.91-0.97),
BACKGROUNDLocal angiotensin activity is thought to play a critical role in arterial wall homeostasis and remodeling, and impaired arterial wall integrity contributes to the pathogenesis of subarachnoid hemorrhage (SAH). million patients with hypertension were assessed. million, followup: 6.3 million, followup: 5.7 million, followup: 5.3
Hypertension, Ahead of Print. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc.
Introduction:Chronic kidney disease (CKD) is a well-established risk factor for spontaneous intracerebral hemorrhage (ICH). This association was reduced to a 19% increase in ICH risk after adjusting for hypertension in multivariable MR (OR 1.19; 95% CI 1.03-1.39; Stroke, Volume 55, Issue Suppl_1 , Page AWP159-AWP159, February 1, 2024.
Hemorrhagic strokes (HS) are increasingly significant causes of disability and mortality worldwide, making the use of blood biomarkers for their diagnosis and prognosis critical. Stroke, Volume 56, Issue Suppl_1 , Page AWP230-AWP230, February 1, 2025.
Introduction:Cerebrovascular white matter disease (WMD) severity is linked to vascular risk factors like hypertension, hyperlipidemia, and diabetes. In stroke, it has been associated with infarct growth, hemorrhagic transformation, and poor outcomes. Stroke, Volume 56, Issue Suppl_1 , Page ATP170-ATP170, February 1, 2025.
Introduction:Superficial (gray matter, vermis) cerebellar intracerebral hemorrhage (cICH) is associated with strictly lobar supratentorial cerebral microbleeds—a strong marker for cerebral amyloid angiopathy. Of these, 83 (64%) patients had deep cICH and 46 (36%) patients had superficial cICH.
Contributing factors such as hypocholesterolemia and hypertension amplify the risk of ICH and subsequent hematoma expansion, underscoring the urgent need for effective interventions. Standardized studies are imperative to inform evidence-based clinical decisions and improve outcomes for individuals afflicted with intracranial hemorrhage.
The majority (77%) of MSU patients received anti-hypertensive medications while in the MSU. In the EMS cohort, only patients seen between 8 am to 8 pm, corresponding to the operating hours of the MSU, were included. Initial systolic blood pressure in the hospital was significantly higher for EMS compared to MSU patients (166 vs 157, p=0.011).
Background and Objectives:It is unclear whether induced hypertension in acute ischemic stroke (AIS) may improve long-term outcomes. The safety outcome was symptomatic intracranial hemorrhage (sICH). sICH did not differ between patients treated with induced hypertension (<1%) versus control (<1%) (OR 1.03; 95% CI 0.14-7.45;
Background and Purpose:Intracerebral and subarachnoid hemorrhages comprise roughly 15% of all strokes but have a higher risk of mortality and morbidity than ischemic strokes. Controlling hypertension after a hemorrhage is the primary intervention to limit the risk of hematoma expansion (HE) and the sequelae of secondary injury.
BACKGROUND:Cerebellar intracerebral hemorrhage (cICH) is often attributed to hypertension or cerebral amyloid angiopathy (CAA). 36.73];P=0.01), hypertension (84.4% Stroke, Volume 54, Issue 12 , Page 3074-3080, December 1, 2023. However, deciphering the exact etiology can be challenging. versus 3.4%; OR, 41.39 [95% CI, 5.01–341.68];P=0.001),
Introduction:Intracerebral hemorrhage (ICH) is a major cause of maternal mortality, but its pathophysiology is not well characterized. Participants were identified from an internal stroke registry and through the ICHOP (Intracerebral Hemorrhage Outcomes Project) study. secondary) ICH (adjusted OR 4.9,
Introduction:Patients with intracerebral hemorrhage (ICH) often undergo CT and CT angiography with the latter being done to identify vascular abnormalities for ICH etiology. Univariate logistic regression estimated unadjusted effects of ICH type, age, hypertension (HTN), and other predictors on the logit of vascular abnormalities.
Introduction:Intracranial hemorrhage (ICH) is the most severe adverse effect of anticoagulation in atrial fibrillation (AF) patients. Hypertension, diabetes, hyperlipidemia, and chronic kidney disease are well-known cardiovascular risk factors for ICH. Stroke, Volume 56, Issue Suppl_1 , Page A49-A49, February 1, 2025.
IntroductionAneurysmal subarachnoid hemorrhage (aSAH) accounts for about 10% of hemorrhagic strokes [1] and holds a high mortality and morbidity rate. [2, Head CT on arrival showed a diffuse subarachnoid hemorrhage, more prominent in the posterior fossa, and grade IV on the modified Fisher scale.
We compared hemorrhagic change after MT, outcome at discharge and clinical characteristics between two groups. We compared hemorrhagic change after MT, outcome at discharge and clinical characteristics between two groups. The occurrence of hemorrhagic change was assessed on CT after MT.
Outcomes of MSU management in patients with intracranial hemorrhage (ICH) have not been reported.Methods:We conducted a retrospective review of ICH patients enrolled in the Benefits of Stroke Treatment Using a Mobile Stroke Unit (BEST-MSU), a prospective multicenter controlled trial comparing MSU with standard EMS management (SM).
Less is known about disparities in risk and outcomes for young patients presenting with intracerebral hemorrhage (ICH), which is associated with higher short-term and long-term mortality. Racial and ethnic disparities in risk factors and outcomes for young patients with ischemic stroke (AIS) are well described.
The timing of ischemic stroke (IS) and hemorrhagic stroke (HS) in relation to MPN diagnosis among Veterans remains undefined.We utilized the Veterans Affairs Informatics and Computing Infrastructure database from 1/1/2006 - 1/26/2023 and included 586,555 Veterans from Illinois, the state most representative of the US population.
IntroductionSubarachnoid hemorrhage (SAH) has an estimated prevalence of 7.9 Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. per 100,000 person yearsi. It is primarily caused by the rupture of intracranial aneurysms, leading to severe consequences and a 60% 6‐month mortality rateii. were intervened on.
IntroductionSubarachnoid Hemorrhage (SAH) is the leading cause of morbidity and mortality in stroke patients, associated with severe neurological, infectious, and thromboembolic complications. Further studies are required to offer risk stratification and prevention strategies for readmission among patients with Subarachnoid Hemorrhage.
Background and Purpose:The role of surgical evacuation using craniotomy or endoscopic procedure in patients with intracerebral hemorrhage (ICH) associated with oral anticoagulants is not well described. Stroke, Volume 55, Issue Suppl_1 , Page AWP209-AWP209, February 1, 2024.
Introduction:Pregnant patients are at risk of neurological complications including intracerebral hemorrhage (ICH). vs 63.38, p<0.001) and had fewer comorbidities such as cancer and chronic kidney disease, atrial fibrillation, hypertension, hyperlipidemia. Stroke, Volume 55, Issue Suppl_1 , Page AWMP80-AWMP80, February 1, 2024.
Cases had a maternal stroke (ischemic, hemorrhagic, subarachnoid hemorrhage, or cerebral venous thrombosis) during pregnancy or PP, identified from a stroke registry.
Objectives:Spontaneous intracerebral hemorrhage (ICH) is caused by the rupture of small arterioles due to cerebral small vessel disease (SVD), commonly with hypertensive arteriolosclerosis (HTA) or cerebral amyloid angiopathy (CAA). Stroke, Volume 56, Issue Suppl_1 , Page ATMP63-ATMP63, February 1, 2025.
Background:The 2023 American Heart Association/American Stroke AssociationsGuideline for Management of Patients with Aneurysmal Subarachnoid Hemorrhage(SAH) support use of the Ottawa Rule to screen individuals at risk. The ED lacked a formal triage process for identification of SAH resulting in delayed treatment.
The primary outcome was a composite of the incidence of myocardial infarction and ischemic and hemorrhagic stroke, obtained by tracking the medical use data of the first-ever ICD-10 codes. Circulation, Volume 150, Issue Suppl_1 , Page A4113411-A4113411, November 12, 2024. years and median follow-up duration was 15.9
Qualitative data were compared by chi-square tests.Among 586,555 Veterans from Illinois, there were 15,455 ischemic stroke (IS), 1,593 hemorrhagic stroke (HS), 2,752 MPN, and 59,393 with AO exposure. AO exposure was verified on the Veterans’ service duration and location. Among MPNs, there were 237 IS (41 with AO) and 26 HS (3 with AO).
Introduction:Cerebral amyloid angiopathy (CAA) is an age-related cerebral small vessel disease that can lead to poor outcomes due to cerebral hemorrhage. The same applies to hypertensive cerebral small vessel disease (HTN-CSVD). Stroke, Volume 56, Issue Suppl_1 , Page AWP188-AWP188, February 1, 2025.
Background:Cerebral vasospasm in non-traumatic subarachnoid hemorrhage (SAH) is associated with a high rate of morbidity and mortality. Patients with seizures were more likely to be White or Hispanic, and to have systemic inflammatory disease, hyperlipidemia and hypertension (all p<0.001). vs. 7.70 ± 7.77; p<0.001).
Transcript of the video: Eisenmenger syndrome is an important complication of large left to right shunts which develop later due to development of pulmonary vascular obstructive disease and severe pulmonary hypertension. This highlights one of the most important complications of Eisenmenger syndrome, that is airway hemorrhage.
In the total population, 25% had an intracerebral hemorrhage, 56% had an ischemic stroke, and 19% had a subarachnoid hemorrhage. However, the frequency of subarachnoid hemorrhages was the lowest in the WA cohort (9%) in comparison to AA (33%) and those WAA lineage (22%), p-value 0.017.
It has articles, ranging from from simple clinical studies on postpartum hemorrhage (E-MOTIVE study) from deep inside Africa by Melinda Gate foundation, to Dupilumab for COPD, a stunning monoclonal antibody inhibitor of IL-4 for COPD exacerbations.
We evaluated the extent of orosomucoid deposition in patients with CAA and control using pathological specimens, and also compared orosomucoid expression in type 1, type 2 CAA and control. In the comparison between the three groups, immunohistochemistry higher expression of orosomucoid in the arteries/ arterioles of CAA type1 than control group.
The rates for hemorrhagic stroke were 0.68%, 0.55%, 0.81%, and 4.90% for the same groups. Particularly for those younger than 50, those without hypertension, and those presented with ST-elevation myocardial infarction. Specifically, the rates of ischemic stroke for these groups were 2.95%, 3.12%, 3.96% and 10.11% respectively.
Introduction:Neurological complications in patients with infective endocarditis (IE), such as ischemic and hemorrhagic stroke, are well-described, serious complications of IE; however, predicting which patients are most likely to experience stroke remains uncertain. Stroke, Volume 56, Issue Suppl_1 , Page AWP279-AWP279, February 1, 2025.
To characterize disease severity, we report the coincidence of any stroke (ischemic stroke, intracerebral hemorrhage [ICH], subarachnoid hemorrhage [SAH]) using previously validated ICD-10-CM codes, length of stay, need for mechanical ventilation, and discharge destination. Among patients with PRES, 3,950 (10.0%; 95% CI, 9.4-10.7%)
Hypertension, Ahead of Print. Pharmacological inhibition of EGFR or downstream ER stress may be a promising therapeutic strategy for preventing aneurysm rupture and subarachnoid hemorrhage. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms.
Objectives:Mixed location intracerebral hemorrhages/ microbleeds (CMBs) (mixed ICH) is referred to as potential hypertensive arteriolosclerosis/cerebral amyloid angiopathy (CAA) combination, reflecting small vessel disease (SVD) burden. There were no significant differences in hypertension, dyslipidemia, and diabetes.
Only dAVFs with cortical venous drainage were included as this aggressive subtype can present with non‐hemorrhagic neurologic deficits. It was found that all cases of dAVF‐CI exhibited venous hypertension. ConclusiondAVFs‐CI tend to occur in relatively young patients and are characterized by the presence of venous hypertension.
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