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At present, the main methods to treat ischemic heart disease are drug therapy, intervention and operation. These methods only alleviate symptoms of heart failure and myocardialischemia and improve patients' quality of life by partially restoring myocardial reperfusion.
BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardialischemia/reperfusion injury. Tafazzin is an enzyme that is required for cardiolipin maturation.
Previous trials evaluating the potential benefits of this and other heart pumps for cardiogenic shock have had mixed results. of those who received the Impella pump had died at six months after randomization; there was a 13 percentage point absolute reduction in the rate of death, the study’s primary endpoint, in favor of the heart pump.
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