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Tenax Therapeutics Announces New U.S. Patent Covering the Use of Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

DAIC

Initially discovered and developed by Orion Corporation in Finland, intravenous levosimendan is approved in 60 countries outside the United States for use in hospitalized patients with acutely decompensated heart failure. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,

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Evaluation of the Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction

American College of Cardiology

The goal of the CAMEO-DAPA trial was to assess whether dapagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i), affects rest and exercise pulmonary capillary wedge pressure (PCWP) in patients with heart failure with preserved ejection fraction (HFpEF).

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Dapagliflozin and Right Ventricular Pulmonary Vasculature in HFpEF

JAMA Cardiology

This randomized clinical trial investigates the effect of dapagliflozin on right ventricular performance and vascular load during exertion in heart failure with preserved ejection fraction (HFpEF).

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Right ventricular function and anemia in heart failure with preserved ejection fraction

Frontiers in Cardiovascular Medicine

BackgroundAnemia is a common complication in patients with heart failure and is associated with left ventricular systolic dysfunction.

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Heart Failure in Zero Gravity—External Constraint and Cardiac Hemodynamics

JAMA Cardiology

In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity during parabolic flight to assess the effect of external constraint on left ventricular filling pressures.

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Heart Failure With Preserved Ejection Fraction Phenotype Is Associated With Early Symptom Onset in Aortic Stenosis and Residual Symptoms After Transcatheter Aortic Valve Implantation

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundAortic stenosis can lead to cardiac adaptations and symptoms similar to heart failure with preserved ejection fraction. Methods and ResultsThis retrospective cohort study included 469 patients with moderate aortic stenosis.

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Top 10: Must-reads from the Month of May

DAIC

American College of Cardiology (ACC) and American Heart Association (AHA) Issue New Hypertrophic Cardiomyopathy (HCM) Management Guidelines 2. New Study Published in JACC: Heart Failure Reveals that Despite Significant Efforts to Improve Acute Heart Failure Treatment Over the Past 20 Years, Management Remains Unchanged 3.