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Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?

Frontiers in Cardiovascular Medicine

Background The obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). Conclusion In not hospitalized patients with HFREF of ischemic etiology, obesity was not a protective factor.

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The Atrial Fibrillation and Heart Failure with Preserved Ejection Fraction "Twindemic” - Shared Root Causes and Treatment Targets

HeartRhythm

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are comorbid conditions that are increasingly prevalent and have a high socioeconomic burden. This article discusses their shared pathophysiology, focusing on the triad of hypertension, obesity, and aging.We

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Outcomes Associated With Surgical and Pharmacologic Treatment of Obesity in Heart Failure

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.

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Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

Journal of the American Heart Association

AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia.

Obesity 45
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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52
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Empagliflozin: primum inter pares among sodium-glucose cotransporter-2 inhibitors?

Journal of Cardiovascular Pharmacology

Sodium/glucose cotransporter 2 (SGLT2) inhibitors are a novel class of anti-diabetic medications which have proved capable of providing breakthrough cardiovascular benefits in a variety of clinical scenarios, including patients with heart failure or obesity, irrespective of diabetic status.

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So close, yet so far away: the relationship between MAM and cardiac disease

Frontiers in Cardiovascular Medicine

Notably, MAM exhibits various regulatory effects to maintain cellular balance in several cardiac diseases conditions, such as obesity, diabetes mellitus, and cardiotoxicity. Cardiac diseases caused by any reason can lead to changes in myocardial structure and function, significantly impacting human health.