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Background Heartfailure with preserved ejection fraction is a recognised outcome in patients with myocardialinfarction, although heartfailure with reduced ejection fraction is more common. Among patients with myocardialinfarction, a 1-SD increase in pulse pressure was associated with a 1.60-fold
Heartfailure (HF) is one of the significant complications in patients with myocardialinfarction (MI), leading to increased risk for cardiovascular morbidity and mortality. 2 However, mortality rate is greater in HF cases developing >3 days following MI compared with less than or equal to 3 days after MI.
IntroductionCellular senescence can cause heartfailure. However, studies on diagnostic markers related to cellular senescence in acute myocardialinfarction (AMI) have not been reported.
Curtain etal1 performed an analysis of the VALIANT (Valsartan in Acute MyocardialInfarction) and PARADISE-MI (Prospective ARNi vs ACE Inhibitor Trial to Determine Superiority in Reducing HeartFailure Events After MI) trials to evaluate whether risk of sudden cardiac arrest (SCA) following acute myocardialinfarction (MI) has changed over time.
Background Atrial fibrillation (AF) and acute myocardialinfarction (AMI) share risk factors and are bidirectionally associated. Several studies found higher risks of outcomes in individuals with both conditions. Whether the risks of outcomes differ according to temporal order of AF and AMI is unclear.
a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced success from a collaborative Phase II trial of ProtheraCytes for the treatment of acute myocardialinfarction (AMI) led by CellProthera , as well as plans to continue the relationship into Phase III.
The goal of the EMPACT-MI trial was to determine whether adding the sodium-glucose cotransporter-2 (SGLT2) inhibitor empagliflozin to the treatment of acute myocardialinfarction (AMI) affects future mortality or heartfailure (HF) in at-risk patients.
A number of therapies that have been shown to be effective in patients with chronic heartfailure, including beta-blockers, mineralocorticoid receptor antagonists, and renin–angiotensin system inhibitors, have also been shown to be beneficial in patients with evidence of left ventricular systolic dysfunction, pulmonary congestion, or both after an (..)
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heartfailure, possibly by improving the metabolism of ketone bodies in the myocardium.
The appropriate duration of beta-blocker treatment after a heart attack (a myocardialinfarction [MI]) is unknown in patients who do not need to take beta-blockers for another reason.
The impact of sodiumglucose cotransporter-2 (SGLT2) inhibitors on mortality following myocardialinfarction (MI) remains uncertain. Additionally, the role of type 2 diabetes mellitus (T2DM) and heartfailure.
This case report describes a unique instance of a patient developing AEF following AF ablation, accompanied by ischemic stroke and myocardialinfarction. Upon admission, physical examination and laboratory tests revealed vital signs within abnormal ranges and indicators suggesting inflammation and potential myocardial injury.
atrial fibrillation (AF), a heart condition that causes an irregular heartbeat in the upper chambers of the heart, affects up to one in three people in their lifetime. Significant complications associated with this condition include ischemic stroke, heartfailure, myocardialinfarction, chronic kidney disease, dementia and mortality.
Myocardialinfarction (MI), stroke, peripheral arterial disease (PAD), heartfailure (HF) and chronic kidney disease (CKD) are common cardiovascular renal diseases (CVRD) manifestations for type 2 diabetes.
A BMJ study out of Denmark provided alarming new insights into atrial fibrillation’s impact on patients’ future cardiovascular health, while highlighting the need to improve post-AFib heartfailure and stroke prevention. Heartfailure was the most frequent post-AFib complication with a 41.2% in 2000-2010 to 30.9%
Background In acute heartfailure (HF), reduced cardiac output, vasoconstriction and congestion may damage the intestinal mucosa and disrupt its barrier function. We aimed to investigate gut leakage markers and their associations with inflammation, infarct size and cardiac function.
This secondary analysis of a randomized clinical trial examines the antibody response to high-dose trivalent compared with standard-dose quadrivalent inactivated influenza vaccine in patients with a recent acute myocardialinfarction or heartfailure hospitalization.
Data on major cardiovascular events (MACE; mortality, myocardialinfarction, stroke, heartfailure) through December 2021 were obtained from national registries. Results Among all patients (n = 38,671), 31% had stable CAD, and 69% suffered an acute myocardialinfarction.
More than half of the patients presented with heartfailure (n=2,234, 55.4%), followed by acute myocardialinfarction (n=1,368, 34.0%), coronary artery disease (n=674, 16.7%), and acute coronary syndrome (n=164, 4.1%). Poor ventricular function (26.16.8
Cardiovascular hospitalization rates were higher in the US than in Denmark, driven by a significant increase in heartfailure and myocardialinfarction hospitalizations.
Autonomic dysfunction caused by spinal cord injury is associated with abnormalities in blood pressure, heart rate variability, arrhythmias and blunted cardiovascular response to exercise which can limit the capacity to perform physical activity [1]. Survivors with severe disability had the highest risk. Am J Phys Med Rehabil. PMID: 17251696.
Mediation analyses were performed to assess the proportion mediated by MDD. Results Genetically predicted insomnia, short sleep, daytime napping and daytime sleepiness increased the risk of CVDs, with the OR ranging from 1.24 (95% CI 1.06 to 1.45) for insomnia on stroke to 1.55 (95% CI 1.28 to 1.89) for insomnia on MI.
Journal of the American Heart Association, Ahead of Print. BackgroundMyocardial fibrosis is a pathological hallmark of heartfailure post infarction, emphasizing the need for innovative treatment strategies. Mesenchymal stem cellderived EVs, loaded with PAP, were encapsulated in the SA hydrogel (EVsPAP@SA).
Therefore, this meta-analysis aimed to estimate association between TMAO levels and the prognosis of patients with myocardialinfarction (MI).MethodsWe Outcomes included MACE, all-cause mortality, recurrent MI, rehospitalization caused by heartfailure, stroke, revascularization, SYNTAX score, and multivessel disease.
Myocardial remodeling is characterized by gradual heart enlargement, cardiac dysfunction, and extraordinary molecular changes. Cardiac remodeling after myocardialinfarction is almost inevitable, which is the leading cause of heartfailure.
IntroductionHypoxic liver injury (HLI) and Killip classification are poor prognostic factors in patients with ST-segment elevation myocardialinfarction (STEMI). Left ventricular ejection fraction (LVEF) was below 45% in symptomatic, overt heartfailure patients (Killip class II, III, and IV).
These challenges highlight the need for new therapies that are both safe and effective in targeting the structural remodeling pivotal to disease progression post-myocardialinfarction (MI). Current treatments are limited by side effects, poor patient compliance, and the necessity for gradual drug titration.
BackgroundRecent evidence highlights an increasing incidence of myocardialinfarction in young women. years]) admitted to the China Chest Pain Center Database between 2016 and 2021.
Background Hyperglycemia, characterized by elevated blood glucose levels, is frequently observed in patients with acute coronary syndrome, including ST-elevation myocardialinfarction (STEMI). 2.17), heartfailure (pooled RR 1.56, 95% CI: 1.37–1.77), 2.18)) with a pooled RR of 1.58 (95% CI 1.26–1.97).
Gout is a metabolic disease caused by decreased blood uric acid excretion and purine metabolism disorders. Long-term and persistent metabolic dysfunction gradually affects other organ functions and is the main.
BACKGROUND:Microvascular obstruction (MVO) is associated with heartfailure (HF) following ST-segmentelevation myocardialinfarction. Circulation: Cardiovascular Imaging, Ahead of Print.
Nitrate therapy has potential benefit in myocardialinfarction and acute heartfailure. Although the contemporary shock stages classification provided a standardized shock severity assessment, individual agents or management strategy has not yet been studied in the context of each shock stage.
The risk of incident heartfailure (HF) after a myocardialinfarction (MI) is up to six-fold higher than the risk of recurrent MI and the prognosis is worse among those who develop incident HF, regardless of LVEF category.
ObjectiveTo investigate the therapeutic effect of Vericiguat combined with “new quadruple” drugs on patients with heartfailure (HF).MethodsFrom ConclusionVericiguat combined with the “new quadruple” therapy has a significant therapeutic effect on patients with heartfailure caused by MI, DCM or VHD.
Does the development of cardiovascular (CV) events, specifically myocardialinfarction (MI) or heartfailure (HF), in breast cancer survivors influence their oncologic outcomes?
Circulation: HeartFailure, Volume 17, Issue 12 , Page e011629, December 1, 2024. Spironolactone, a steroidal mineralocorticoid receptor antagonist (MRA), has been used to treat patients with heartfailure (HF) for more than half a century.
Journal of the American Heart Association, Ahead of Print. BackgroundCarotid intimamedia thickness (CIMT) and carotid distensibility are markers of arterial change; however, little is known of the association with incident heartfailure (HF). CIMT but not carotid distensibility was associated with incident myocardialinfarction.
Study design and intended outcomes of the HF-REVERT study with CDR132L, a synthetic antisense oligonucleotide inhibitor selectively targeting microRNA-132, in patients with reduced left ventricular ejection fraction (LVEF) after myocardialinfarction (MI).
BACKGROUND:Heart failure is associated with a high rate of mortality and morbidity, and ventricular remodeling invariably precedes heartfailure. Circulation, Ahead of Print. Ventricular remodeling is fundamentally driven by mechanotransduction that is regulated by both the nervous system and the immune system.
The International Registry of MitraClip in Acute Mitral Regurgitation following Acute MyocardialInfarction (IREMMI). Methods and results The International Registry of MitraClip in Acute Mitral Regurgitation following Acute MyocardialInfarction (IREMMI) includes 187 patients with severe MR post-MI managed with TEER.
Takotsubo syndrome (TS), an acute form of heartfailure resembling myocardialinfarction, manifests with reversible regional wall motion abnormalities (RWMA) of the ventricles. Modelling human diseases serves as a crucial tool to unveil underlying mechanisms and pathophysiology.
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