Circulation: Heart Failure

JANUARY 28, 2025

Circulation: Heart Failure, Ahead of Print. BACKGROUND:The therapeutic armamentarium for heart failure with preserved ejection fraction (HFpEF) remains notably constrained. compared with single condition exposure 5.21.3% (obesity), 6.73.5% (hypertension), and 9.01.1% (diabetes;P<0.001).

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Preserved Ejection Fraction Heart Failure Obesity Diabetes 40

Journal of the American Heart Association

DECEMBER 29, 2023

Journal of the American Heart Association, Ahead of Print. BackgroundPulmonary hypertension (PH) is highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF), and it is a strong predictor of adverse outcomes.

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Preserved Ejection Fraction Pulmonary Heart Failure Hypertension 40

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Obesity was associated with more first and recurrent heart failure events.

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Preserved Ejection Fraction Obesity Heart Failure BMI 40

Heart BMJ

FEBRUARY 23, 2024

Objective The heterogeneous pathophysiology of the diverse heart failure with preserved ejection fraction (HFpEF) phenotypes needs to be examined. We aim to assess differences in the biomarkers among the phenotypes of HFpEF and investigate its multifactorial pathophysiology.

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Preserved Ejection Fraction Heart Failure Biomarkers Hypertension 40

Hypertension Journal

FEBRUARY 22, 2024

Hypertension, Ahead of Print. Background:We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA) at rest and sympathetic reactivity during a cold pressor test compared with non–heart failure controls.

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Preserved Ejection Fraction Heart Failure Blood Pressure Physiology 40

European Journal of Heart Failure

NOVEMBER 19, 2024

Hypertensive disorders of pregnancy as a risk factor for heart failure. Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations and preeclampsia, a more severe form, in 34%.

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Risk Factors Heart Failure Hypertension Preserved Ejection Fraction 40

American College of Cardiology

JULY 11, 2024

What is the safety and efficacy of tadalafil in patients with heart failure with preserved ejection fraction (HFpEF) and combined postcapillary and precapillary pulmonary hypertension (CpcPH)?

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Preserved Ejection Fraction Heart Failure Pulmonary Hypertension 49

Circulation

MARCH 9, 2025

Circulation, Volume 151, Issue 10 , Page e686-e686, March 11, 2025.

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Preserved Ejection Fraction Article Heart Failure Hypertension 45

Circulation

MARCH 16, 2025

Circulation, Volume 151, Issue 11 , Page e763-e763, March 18, 2025.

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DAIC

JANUARY 23, 2024

Getty Images milla1cf Tue, 01/23/2024 - 13:38 January 23, 2024 — Sequana Medical NV , a pioneer in the treatment of fluid overload in liver disease, heart failure and cancer, announced that an independent Data and Safety Monitoring Board (DSMB) approved the start of the randomized cohort in MOJAVE , the US Phase 1/2a study of DSR 2.0

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Heart Failure Preserved Ejection Fraction Hypertension Cancer 104

Journal of the American Heart Association

DECEMBER 29, 2023

Journal of the American Heart Association, Ahead of Print.

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Preserved Ejection Fraction Pulmonary Heart Failure Hypertension 40

HeartRhythm

APRIL 30, 2024

Introduction: Patients with ‘heart failure with preserved ejection fraction’ (HFpEF) frequently manifest chronotropic incompetence as well as hypertension (HTN). Cardiac pacing may improve clinical outcomes in these patients. To date, pacing has not been regulated by an external hemodynamic input.

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Circulation

NOVEMBER 11, 2024

Intro:Drug Development for Heart failure with Preserved Ejection Fraction (HFpEF) is a major challenge facing cardiovascular research due to its complex pathophysiology and existence of comorbidities, leading to recognize distinct HFpEF phenogroups. l) for 8 weeks.

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Hypertension Preserved Ejection Fraction Blood Pressure Obesity 40

Dr. S. Venkatesan MD

AUGUST 3, 2024

However, It is surprising even in chronic pulmonary hypertension , the degree of RVH is not constant and homogenous.This is because , different parts of RV chamber has different wall thickness.Further, the pressure distribution from PA to RV is uneven. Eur J Heart Fail. Eur J Heart Fail 2016; 18: 226 2018 Jan;20(1):16-37.

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Preserved Ejection Fraction Heart Failure Pulmonary Heart Dysfunction 52

Circulation

APRIL 1, 2025

BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent type of heart failure, but effective treatments are lacking. Cardiac lymphatics play a crucial role in maintaining heart health by draining fluids and immune cells. Circulation, Ahead of Print.

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Circulation

NOVEMBER 11, 2024

The CardioMEMS PA (pulmonary artery) sensor allows remote pulmonary artery diastolic (PAD) pressure monitoring to adjust diuresis in heart failure with preserved ejection fraction (HFpEF).

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Preserved Ejection Fraction Cardiomyopathy Heart Failure Pulmonary 40

Dr. S. Venkatesan MD

APRIL 18, 2024

Shah, author of Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial. Here is an audio podcast from the primary author published in JAMA network. Interview with Sanjiv J. Hosted by James E.

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Preserved Ejection Fraction Pulmonary Congenital Heart Disease VSD 40

DAIC

FEBRUARY 29, 2024

ET Main Tent (Hall B1) Effect of Gamification, Financial Incentives or Both Combined to Increase Physical Activity Among Patients with Elevated Risk For Major Adverse Cardiovascular Events.

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Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Circulation

NOVEMBER 11, 2024

Introduction:Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure which is rapidly rising in incidence in the US today. g/L of an iNOS inhibitor (N-Nitro-L-arginine methylester) to induce hypertension.

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Preserved Ejection Fraction Echocardiogram Exercise Diet 40

European Journal of Heart Failure

APRIL 13, 2025

The beneficial effects of finerenone in patients with heart failure (HF) and mildly reduced or preserved ejection fraction were consistent, regardless of a history of chronic obstructive pulmonary disease (COPD) status.

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Preserved Ejection Fraction Heart Failure Pulmonary Peripheral Arterial Disease 40

DAIC

MARCH 26, 2025

Food and Drug Administration (FDA) accepted its supplemental new drug application (sNDA) and granted Priority Review designation for KERENDIA(finerenone) for the treatment of adult patients with heart failure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF).

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Heart Failure Preserved Ejection Fraction Kidney Disease ACE Inhibitor 52

European Journal of Heart Failure

APRIL 6, 2025

Abstract Aims Oxidative stress is known to be involved in the pathophysiology of heart failure (HF). During a median follow-up of 12.6years, 349 (4.3%) HF events occurred of which 118 (33.8%) had HF with preserved ejection fraction.

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Heart Failure Preserved Ejection Fraction Cholesterol Obesity 40

Circulation

OCTOBER 13, 2023

BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preserved ejection fraction. Nonresistant hypertension was defined as BP above threshold but not meeting aTRH criteria. per 100 patient-years).

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Preserved Ejection Fraction Heart Failure Hypertension Myocardial Infarction 40

European Journal of Heart Failure

FEBRUARY 5, 2025

Beta-blockers are commonly used in patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF). Methods and results We pooled individual patient data from four large HFmrEF/HFpEF trials (I-Preserve, TOPCAT, PARAGON-HF, and DELIVER).

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Preserved Ejection Fraction Heart Failure Outcomes Atrial Fibrillation 40

European Journal of Heart Failure

FEBRUARY 4, 2024

Abstract Aim Pathophysiological differences between patients with heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction (EF) remain unclear. Study design and main study results. In HFrEF, interleukin (IL)-8 and IL-6 were possible targets related to lower EF and worsening renal function.

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Preserved Ejection Fraction Heart Failure Biomarkers Diabetes 40

Frontiers in Cardiovascular Medicine

AUGUST 6, 2024

Hypertension during pregnancy affects up to 10% of pregnancies and is associated with significant cardiovascular morbidity and mortality. Finally, we explore how future cardiovascular risk may be predicted based on cardiac remodelling during or after pregnancy and suggest potential areas of further research in the field.

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Heart Failure Preserved Ejection Fraction Coronary Artery Disease Hypertension 40

Journal of the American Heart Association

JANUARY 23, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundCardiometabolic comorbidities such as obesity, diabetes, and hypertension are highly prevalent in heart failure (HF). Severely uncontrolled comorbidities were defined as systolic blood pressure 160 mm Hg, hemoglobin A1c 8%, and body mass index 35 kg/m2.

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Heart Failure Preserved Ejection Fraction Obesity Outcomes 45

DAIC

MARCH 29, 2024

About Heart Failure Heart failure (HF) is a chronic, progressive disease in which the heart cannot pump enough blood to meet the body's needs. HFpEF is HF with preserved ejection fraction in which pressure builds up in the heart and lungs due to a stiffened left ventricle.

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Preserved Ejection Fraction Heart Failure Quality of Life Hospital 111

Circulation

NOVEMBER 11, 2024

Introduction:The demographics of patients with pulmonary arterial hypertension (PAH) is shifting towards older age, increased comorbidity burden, and an increase in the risk of left ventricular (LV) diastolic dysfunction. 2022 were included. 2022 were included.

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DAIC

JUNE 26, 2024

Getty Images milla1cf Wed, 06/26/2024 - 18:59 June 26, 2024 — Semaglutide , a medication initially developed for type 2 diabetes and obesity, significantly improves symptoms in men and women with a common type of heart failure that has had few therapeutic options.

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Open Heart

FEBRUARY 15, 2023

AFMR is likely to become more common with population ageing, alongside increases in atrial fibrillation and heart failure with preserved ejection fraction; conditions causing atrial dilatation. Advancing age and pulmonary hypertension independently associated with survival in FMR.

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Cardiometabolic Health Congress

JULY 25, 2023

There are significant data that show that if you have obesity, you have a high risk of developing coronary heart disease, heart failure, type 2 diabetes (T2D) or risk factors such as hypertension and dyslipidemia. [1] Is the obesity paradox a real phenomenon?

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Obesity BMI Heart Failure Cardiovascular Disease 52

Journal of the American Heart Association

MARCH 13, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundSparce data suggest higher mortality in heart failure (HF) with left ventricular ejection fraction (EF) >65% to 70%. We characterized EF distribution, characteristics, and outcomes in patients with HF and EF 50%.Methods

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Frontiers in Cardiovascular Medicine

DECEMBER 16, 2024

ObjectiveThe left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression. To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe

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Preserved Ejection Fraction Exercise Heart Failure Hypertension 40

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Heart Failure Management : The FINEARTS-HF trial focused on the efficacy of finerenone, an aldosterone antagonist, in reducing heart failure hospitalizations and cardiovascular mortality among patients with preserved ejection fraction (HFpEF).

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Blood Pressure Obesity Coronary Artery Disease Preserved Ejection Fraction 59

The British Journal of Cardiology

JANUARY 14, 2025

We report from the 19 th Annual Scientific Meeting of the Cardiorenal Forum held in London on 4 th October 2024, which served as a dynamic platform for experts in cardiology, diabetes, and renal medicine to converge and exchange the latest insights on managing heart and kidney failure.

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Innovation Diabetes Preserved Ejection Fraction Outcomes 40

Cardiometabolic Health Congress

NOVEMBER 14, 2024

42% of adults are considered obese , increasing their risk of diabetes, hypertension, and cardiovascular issues. Additionally, 10% of the global population suffers from chronic kidney disease , with diabetes and hypertension as significant risk factors. In the U.S.,

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CME Obesity Heart Failure Biomarkers 103