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Patient Enrollment Commenced in Pivotal Phase 3 Trial of CardiAMP Cell Therapy for the Treatment of Ischemic Heart Failure

DAIC

FDA granted CardiAMP Cell Therapy a Breakthrough Device Designation for the treatment of ischemic heart failure. Leslie Miller, MD , trial investigator at the CHF Heart Function Clinic at BayCare Morton Plant Hospital in Clearwater, Florida and a member of the CardiAMP Heart Failure II Study Executive Steering Committee. “As

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Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?

Frontiers in Cardiovascular Medicine

Background The obesity occurrence has achieved epidemic levels worldwide and several studies indicate a paradoxical similarity among obesity and the prognosis in heart failure (HF). Methods We analyzed 1,556 medical records from the HF outpatient clinic of a quaternary hospital and 242 were selected according to the criteria.

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Current and novel biomarkers in cardiogenic shock

European Journal of Heart Failure

Abstract Cardiogenic shock (CS) carries a 3050% in-hospital mortality rate, with little improvement in outcomes in the last decade. Temporal change in such biomarkers, particularly in response to pharmacological interventions and/or mechanical circulatory support, can guide management and predict outcome.

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New Treatment in Pipeline for Patients with Hypertrophic Cardiomyopathy

DAIC

In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity. The late breaking research was presented by principal investigator Martin S. Cytokinetics Inc. provided the funding for this study.

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Qiliqiangxin: A multifaceted holistic treatment for heart failure or a pharmacological probe for the identification of cardioprotective mechanisms?

European Journal of Heart Failure

In the QUEST trial, QLQX reduced the combined risk of cardiovascular death or heart failure hospitalization (hazard ratio 0.78, 95% confidence interval 0.68–0.90), Taken collectively, these observations support a conceptual framework for understanding the mechanism of action for QLQX in heart failure.

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The Impact of Midodrine On Guideline-Directed Medical Therapy in Patients Admitted with Systolic Heart Failure

Journal of Cardiovascular Pharmacology

Background: Midodrine is occasionally used off-label to treat hypotension associated with advanced heart failure. Objectives: We sought to evaluate the effect of midodrine upon the GDMT prescription pattern and clinical outcomes of patients with decompensated systolic heart failure.

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Optimal Heart Failure Medical Therapy and Mortality in Survivors of Cardiogenic Shock: Insights From the FRENSHOCK Registry

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThe effects of pharmacological therapy on cardiogenic shock (CS) survivors have not been extensively studied.