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Food and Drug Administration (FDA) accepted its supplemental new drug application (sNDA) and granted Priority Review designation for KERENDIA(finerenone) for the treatment of adult patients with heartfailure (HF) with a left ventricular ejection fraction (LVEF) of 40%, i.e., mildly reduced LVEF (HFmrEF) or preserved LVEF (HFpEF).
Mineralocorticoid receptor antagonists (MRAs) are often underutilized in patients with heartfailure (HF), particularly those with diabetes and/or chronic kidneydisease (CKD). However, the impact of concurren.
Getty Images milla1cf Tue, 04/30/2024 - 12:56 April 30, 2024 — A multicenter study led by Vanderbilt University Medical Center ( VUMC ) and Lipscomb University College of Pharmacy in Nashville has identified a potential new treatment for acute heartfailure , a leading cause of hospitalization and death.
This study by Fujita Health University researchers revealed that kidney function, considered in terms of estimated glomerular filtration rate (eGFR), can be used as a predictor for SCD in patients with congestive heartfailure. During the follow-up period, 198 of these patients suffered from SCD.
Myocardial infarction (MI), stroke, peripheral arterial disease (PAD), heartfailure (HF) and chronic kidneydisease (CKD) are common cardiovascular renal diseases (CVRD) manifestations for type 2 diabetes.
Meta-analysis on the main outcomes of angiotensin receptorneprilysin inhibitor (ARNI) in heartfailure (HF) patients with end-stage kidneydisease (ESKD) on dialysis. Abstract Aims Angiotensin receptorneprilysin inhibitor (ARNI) has played an increasingly important role in the management of heartfailure (HF).
However, researchers said the drug may be helpful in reducing heartfailure risks, including hospitalization, following a heart attack. The study enrolled 6,522 people treated for acute myocardial infarction at 451 centers in 22 countries. About 32% had Type 2 diabetes.
Mineralocorticoid receptor antagonist (MRA) use in severe chronic kidneydisease and heartfailure with reduced ejection fraction (HFrEF). Methods and results We analysed patients with HFrEF (ejection fraction <40%), not on dialysis, from the Swedish HeartFailure Registry.
While composite of death and heartfailurehospitalizations was not significantly reduced, empagliflozin may help reduce heartfailure risks after a heart attack, according to results from the EMPACT-MI trial presented on day one of the American College of Cardiology Scientific Sessions, ACC.24,
Journal of the American Heart Association, Ahead of Print. ConclusionsAmong patients with CKD stages 3b/4, patients with hyperkalemia experienced significantly higher risks of major adverse cardiovascular events and arrhythmia in hospital settings relative to patients without hyperkalemia.
Efficacy and safety of finerenone in patients with chronic kidneydisease and type 2 diabetes by diuretic use: a FIDELITY analysis. The incidence of hyperkalaemia leading to hospitalization or study drug discontinuation was low across treatment groups irrespective of diuretic use. Out of 12990 patients, 51.6%
Background:Overall outcomes and the escalation rate for home hospital admissions for heartfailure (HF) are not known. Escalation of care was defined as transfer to an inpatient hospital setting (emergency department, inpatient medical unit) for at least 1 overnight stay. had chronic kidneydisease, and 60.6%
Introduction:The treatment of heartfailure (HF) with hydralazine-isosorbide dinitrate (H-ISDN) in African Americans (AA) with New York Heart Association (NYHA) III-IV who remain symptomatic despite optimal medical therapy is a class Ia indication. Differences in baseline characteristics were analyzed between the two groups.
Aims Heartfailure (HF) is associated with comorbidities which independently influence treatment response and outcomes. post-MDT; p<0.001), initiation of renin–angiotensin aldosterone system inhibitors in HF with reduced ejection fraction (HFrEF) with advanced chronic kidneydisease (9% pre vs 71% post-MDT; p<0.001).
Circulation: HeartFailure, Ahead of Print. Background:Current prevalence estimates of heartfailure (HF) are primarily based on self-report or HF hospitalizations. Overt cardiovascular disease, which ranged from 2.1% (HF) to 13.6% (atrial fibrillation), was less common. were female, 25.6% were Black, 12.8%
Key findings presented at the conference included disparities in access to kidney transplantation and waitlisting based on race and neighborhood characteristics, racial and ethnic differences in incident chronic kidneydisease (CKD), and the use of motivational strategies to improve dialysis nonadherence among African American patients.
The serum creatinine and serum uric acid elevated as the day of hospitalization increased, and the maximum was observed at day-7 i.e., 1.35 ± 0.54 Conclusion:The FeUa seems to be a negative predictor of CRS in patients hospitalized with ADHF. mg/ml and 11.08 ± 15.83 mg/ml, respectively.
Background:Heart failure (HF) is one of the leading causes of hospitalizations in the States. Results:We included 4,454,273 weighted hospitalizations due to HF for which 380,446 patients (8.5%) had a concurrent diagnosis of hyperkalemia. Circulation, Volume 150, Issue Suppl_1 , Page A4113864-A4113864, November 12, 2024.
Abstract Background Extracellular matrix remodeling is one of the key pathways involved in heartfailure (HF) progression. SGLT2 inhibitors may have a role in attenuating myocardial fibrosis. The impact of SGLT2 inhibitors on blood markers of collagen turnover in humans is not fully elucidated.
UC Davis Medical Center is one of the first sites nationwide to have commercial access to TriClip and is the first hospital in Western United States to utilize the system since it was approved by the U.S. Left untreated, tricuspid regurgitation can lead to atrial fibrillation , heartfailure , kidneydisease and even death.
Patients with heartfailure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) have a high risk of developing LRTI. Empagliflozin reduced the risk of lower respiratory tract infections. CI, confidence interval; HR, hazard ratio. Aims Lower respiratory tract infections (LRTI) are common worldwide.
Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular disease risk factors cluster (histories of hyperlipidemia, obesity, anddiabetes, and family history of cardiovascular disease and smoking); (..)
The primary efficacy end point was the composite of cardiovascular death and hospitalizations for heartfailure. The secondary efficacy end points were all‐cause death, cardiovascular death, hospitalizations for heartfailure, kidneydisease progression, and acute kidney injury.
Study end points include mortality, cardiovascular events (hospitalization for acute myocardial infarction or stroke) and limb events (hospitalization for critical limb ischemia or major amputation) and were identified using Veterans Affairs and nonVeterans Affairs encounters.ResultsThe mean age was 70.6 were male, and 18.5%
BACKGROUND:Despite increasing incidences of hypertension, recent trends in mortality and urgent dialysis following acute hypertension (AHT) remain undetermined.METHODS:This retrospective observational cohort study evaluated 50 316 hospitalized AHT patients from 2010 to 2019, using an administrative claims database in Japan. were women.
ABSTRACT Aims The sodiumglucose cotransporter 2 inhibitor canagliflozin reduces the risk of heartfailure (HF) hospitalization or cardiovascular death and chronic kidneydisease (CKD) progression among patients with type 2 diabetes at high cardiovascular risk or with CKD.
Background:Empagliflozin is a sodium glucose co-transporter 2 inhibitor that improves cardiovascular outcomes in patients with type 2 diabetes mellitus, chronic kidneydisease and heartfailure. vs 5.4%), and hospitalization for heartfailure (RR 0.66; 95% CI [0.58, 0.76]; P < 0.00001; 3.2%
We aimed to compare in-hospital mortality and predictors in stroke patients with secondary rheumatological conditions.Methods:Using the National Inpatient Sample (NIS), we identified patients ≥18 admitted for stroke (Jan 2019 - Dec 2020), stratified into RA, SLE, scleroderma, or vasculitides groups using ICD-10-CM codes.
The CANVAS Program included participants with type 2 diabetes at elevated cardiovascular risk, whereas the CREDENCE trial included participants with type 2 diabetes and albuminuric chronic kidneydisease. Canagliflozin reduced the risk of major adverse cardiovascular events (HR, 0.84 [95% CI, 0.76–0.94])
AF-CHF trial in those with AF and congestive heartfailure also failed to show any advantage for the rhythm control strategy [3]. Overall, it appears that rhythm control strategy in AF may be better in those with heartfailure and in those with associated cardiovascular conditions and early AF.
Background Anemia and ID are common comorbidities in cardiovascular patients and are associated with a poor clinical status, as well as a worse outcome in patients with heartfailure and AMI. Nevertheless, data concerning the impact of anemia and ID on clinical outcome in patients with CS are scarce.
The ADA recommends in patients with ASCVD, when prevention of further vascular events is the priority, a GLP1RA should be added; and when concern for heartfailure or chronic kidneydisease is the priority, a SGLT2i should be added.Objective:Among a cohort of patients with diabetes presenting with AIS, we analyzed rates of GLP1RA and SGLT2i use during (..)
AFib causes a variety of symptoms, including fast or chaotic heartbeat, fatigue, shortness of breath, and chest pain, and causes about 450,000 hospitalizations each year, according to the Centers for Disease Control and Prevention. For example, kidneydisease is not included in CHA 2 DS 2 -VASc.
There are significant data that show that if you have obesity, you have a high risk of developing coronary heartdisease, heartfailure, type 2 diabetes (T2D) or risk factors such as hypertension and dyslipidemia. [1] Is the obesity paradox a real phenomenon?
Measuring eGFR and albuminuria is recommended for assessing kidneydisease in all hypertensive patients. Solomon, MD and Muthiah Vaduganathan, MD, MPH (USA) presented results showing that finerenone significantly reduced heartfailurehospitalizations and cardiovascular death in patients with HFmrEF and HFpEF.
He also had a history of chronic kidneydisease, stage III. Angio had shown some acute disease in the saphenous vein graft to the posterior descending artery off of the RCA. Thus, hypokalemia is prevalent immediately after out-of-hospital cardiac arrest, whereas it is uncommon in AMI in the absence of cardiac arrest.
Background Heartfailure (HF), type 2 diabetes (T2D) and chronic kidneydisease (CKD) commonly coexist. We also estimated rates of healthcare utilisation in primary care and hospital settings in follow-up. We studied characteristics, prognosis and healthcare utilisation of individuals with two of these conditions.
BackgroundThe relation between age at diagnosis of type 2 diabetes (T2D) and hospitalization for heartfailure (HHF) is unclear. Additional adjustment for mediators (hypertension, coronary artery disease, and chronic kidneydisease) marginally attenuated this relationship.
Factors considered in analysis include patient age, sex, geographic region, Medicaid dual eligibility, disability status prior to age 65, comorbidities, admission length of stay, discharge disposition, and hospital characteristics. 1.378]), and heartfailure (1.282 [95%CI, 1.25‐1.315]).ConclusionPatient
Methods:Deidentified administrative discharge data included all individuals admitted to SC hospitals between 2010 and 2019 with ICD-9/10 codes for ischemic stroke. This study aims to assess sociodemographic profile and stroke risk factors among individuals residing in FDs within the predominantly rural state of South Carolina (SC).Methods:Deidentified
By Ravi Dhingra, MD, MPH, FACC, FAHA Sponsored By AstraZeneca Despite improving outcomes in patients with heartfailure [1] , renin-angiotensin-aldosterone system inhibitor (RAASi) therapy is underutilized due to hyperkalemia (HK), often to the detriment of patients. [2] All RAASi classes were included. J Am Coll Cardiol. BMC Nephrol.
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