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Researchers report a discovery in cardiac regeneration that offers new hope for the treatment of ischemic heartfailure. Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation. The researchers are from the Michael E.
The existing oral and intravenous forms of bumetanide are commonly prescribed for people with heartfailure because they ease tissue swelling, a common cause of symptoms for people with heartfailure.
A research team from the Nagoya University Graduate School of Medicine has discovered a promising way to slow the progression of heartfailure in mice. They fed mice a diet rich in the soybean protein, β-conglycinin (β-CG), which can support heart health by influencing gut bacteria.
Nature Reviews Cardiology, Published online: 26 June 2024; doi:10.1038/s41569-024-01046-6 In this Review, Khan and colleagues explore the evolving global epidemiology of heartfailure (HF), focusing on changes in incidence and prevalence across the spectrum of left ventricular ejection fraction.
We over-admit low risk acute heartfailure patients and under-admit high risk heartfailure patients. The post Ep 197 Acute HeartFailure Risk Stratification and Disposition appeared first on Emergency Medicine Cases.
Statement Highlights: Previous studies have found that 14-81% of patients with heartfailure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.
A new small study has revealed the impact of obesity on muscle structure in patients having a form of heartfailure called heartfailure with a preserved ejection fraction (HFpEF).
An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heartfailure and frailty, conditions that commonly develop in late life.
This secondary analysis of the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With HeartFailure (FINEARTS-HF) randomized clinical trial evaluates the effect of finerenone on outpatient worsening heartfailure events requiring oral diuretic intensification among patients with heartfailure with mildly reduced or (..)
The increasing prevalence of heartfailure (HF) has led to advancements in therapeutic strategies, including the development of new pharmacological treatments and the expansion of guideline recommendations across the spectrum of left ventricular ejection fractions.
a biomarker-guided predictive care company, has presented data showing its FDA-cleared, non-invasive, biomarker-based technology for remote heartfailure monitoring detected twice as many heartfailure events as compared to the weight-based standard of care. Bodyport Inc., Image courtesy: Bodyport Inc.
People hospitalized for infectionsalmost any infectionsare at substantially increased risk years later for heartfailure, according to collaborative research by the University of Minnesota and Mayo Clinic.
have the lowest death rate for heartfailure patients in the country, according to CMS data. Chicago-based Northwestern Memorial Hospital and VA Boston Healthcare System-Jamaica Plain (Mass.)
In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heartfailure.
BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heartfailure, with distinct roles attributed to different types of immune cells.
The association between ACC and clinical outcomes in HF patients was analyzed using Cox proportional hazards regression and restricted cubic spline models.ResultsA total of 4,737 heartfailure patients were included.
Despite proven benefits in reducing morbidity and mortality, many heartfailure (HF) patients do not receive optimal guideline-directed medical therapy (GDMT). ESC HeartFailure 2024; 11 : 560–569. The post Digital Consults to Enhance HeartFailure Treatment: The ADMINISTER Trial appeared first on Cardiology Update.
In partnership with Abbott, the American Heart Association has launched a $3 million initiative to address knowledge gaps found within heartfailure treatment education that may be contributing to cardiovascular care disparities.
This prespecified analysis of the Finerenone Trial to Investigate the Efficacy and Safety Superior to Placebo in Patients With HeartFailure (FINEARTS-HF) randomized clinical trial investigates the long-term effects of treatment with the nonsteroidal mineralocorticoid receptor antagonist, finerenone, in patients with heartfailure with mildly reduced (..)
Finerenone reduced the composite of total first and recurrent heartfailure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial.
Researchers have reduced scar formation and improved heart function in mouse models of heartfailure using a monoclonal antibody treatment, similar to that approved by the FDA to treat other conditions.
However, its role in critically ill patients with acute heartfailure (acute HF) remains underexplored.MethodsWe conducted a retrospective cohort study on patients with acute HF included in the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database.
This Viewpoint recommends simultaneous or rapid sequence initiation of combination therapy with 3 specific classes of medication for heartfailure with mildly reduced ejection fraction or preserved ejection fraction.
Association of clonal haematopoiesis with heartfailure incidence and outcomes: A systematic review and meta-analysis. Clonal haematopoiesis and heartfailure: a meta-analysis. CH, clonal haematopoiesis; CI, confidence interval; HF, heartfailure.
A novel study co-authored by a heartfailure cardiologist demonstrates the effectiveness of a newly developed scoring system in identifying patients with HeartFailure with Preserved Ejection Fraction (HFpEF).
In adults with congenital heart disease (ACHD patients), atrial arrhythmias (AA) and heartfailure (HF) are common. 1 Factors related to congenital heart disease, such as underlying anatomy, surgical repair technique and scars, can all be considered as AA substrates.
Research Highlights: In mice with heartfailure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy. Researchers hope this study may help to improve our.
A specially designed drug prevented laboratory mice from developing heartfailure after heart attacks, according to new research from Cedars-Sinai. This discovery could lead to new treatments to prevent heartfailure, a serious cardiac condition that develops in up to 30% of heart attack survivors within one year.
A novel study co-authored by a heartfailure cardiologist at University Hospitals Harrington Heart & Vascular Institute demonstrates the effectiveness of a newly developed scoring system in identifying patients with HeartFailure with Preserved Ejection Fraction (HFpEF).
AimThe association between red cell distribution widthalbumin ratio (RAR) and the risk of all-cause mortality in intensive care unit (ICU) patients with heartfailure remains uncertain. database was utilized for the analysis of ICU patients with heartfailure.
Background We evaluated the potential of circulating bone morphogenetic protein 10 (BMP10) as a biomarker for atrial stress and remodelling in patients with heartfailure (HF), in comparison to N-terminal pro-B-type natriuretic peptide (NT-proBNP). We also assessed the predictive value of BMP10 for adverse clinical outcomes.
Heartfailure during pregnancy is a dangerous and often under-detected condition because common symptoms -- shortness of breath, extreme fatigue and trouble breathing while lying down -- are easily mistaken for typical pregnancy discomforts.
Scientists discovered that blocking the activity of the hormone glucagon could treat a common and challenging type of heartfailure that affects millions worldwide.
Heartfailure is a leading cause of death worldwide and is especially fatal for people who don't have access to medical facilities. So, a team of researchers aims to bring heartfailure screening from the lab to the home.
Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heartfailure for patients with obesity and heartfailure with preserved pump function, new research reveals.
Background Iron deficiency (ID) is a highly prevalent comorbidity in patients with chronic and acute heartfailure and is associated with worse clinical outcomes. We aimed to evaluate the prevalence and clinical characteristics of ID and its association with in-hospital congestion and postdischarge outcomes.
A critical review of cell-based and cell product-based therapies for the treatment of heartfailure details 20 years of completed and ongoing clinical trials. While none has yet gained medical approval, pathways to new treatments for heartfailure can take decades, as seen for two other, now accepted therapies.
In this Review, Zhang and colleagues provide an overview of the evolution of cell-based and cell product-based therapies for the treatment of heartfailure, including challenges and lessons learned, and summarize ongoing clinical trials on the feasibility of novel or underexplored treatment protocols.
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