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A new therapeutic target for a lethal form of heart failure: ALPK2

Science Daily - Heart Disease

Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team has now identified an enzyme, alpha-kinase 2 (ALPK2), that is specifically expressed in the heart and regulates the heart dysfunction that leads to heart failure with preserved ejection function.

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HeartSciences Announces Allowance of U.S Patent for AI-ECG Assessment of Left Ventricular and Right Ventricular Heart Dysfunction

DAIC

Heart failure (HF) is a growing worldwide public health issue affecting 64 million people annually 1 and is associated with high mortality, lower quality of life and reduced physical capacity while placing substantial costs on the healthcare system.

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Aria CV Announces First Patient Successfully Implanted with Second-Generation Pulmonary Hypertension System

DAIC

The Aria CV Pulmonary Hypertension System is an implantable gas-filled balloon that is introduced percutaneously and functions in the main pulmonary artery to alleviate the excessive workload on the right heart that results in right heart failure. This program is intended to expedite development of novel medical devices. “We

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SGLT-2 Inhibitors Show Mixed Results After Heart Attack

DAIC

However, researchers said the drug may be helpful in reducing heart failure risks, including hospitalization, following a heart attack. The study enrolled 6,522 people treated for acute myocardial infarction at 451 centers in 22 countries. About 32% had Type 2 diabetes.

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EMPACT-MI Trial Outcomes Reported at ACC24: SGLT-2 Inhibitors Show Mixed Results After Heart Attack

DAIC

While composite of death and heart failure hospitalizations was not significantly reduced, empagliflozin may help reduce heart failure risks after a heart attack, according to results from the EMPACT-MI trial presented on day one of the American College of Cardiology Scientific Sessions, ACC.24,

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Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction

Cardiovascular Diabetology

Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in ag.

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Heart–brain interaction in cardiogenic dementia: pathophysiology and therapeutic potential

Frontiers in Cardiovascular Medicine

An increasing number of preclinical and clinical studies have confirmed a causal relationship between heart and brain diseases. Cardiogenic dementia is a cognitive impairment caused by heart dysfunction and has received increasing research attention.