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The impact of pre-transplant ventricular assist device support in pediatric patients with end-stage heart failure on the outcomes of heart transplantation—“a single center experience”

Frontiers in Cardiovascular Medicine

IntroductionThe objective of this study was to examine the impact of ventricular assist device support as a bridge to heart transplantation in children with end-stage heart failure. Patients were divided into two groups: with pre transplant ventricular assist device (VAD) support and without VAD support.

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Overcoming the Odds with Expert Fetal Cardiology Care: Zeke and Zane’s Story

Conquering CHD

Zeke and Zane were both diagnosed with hypoplastic left heart syndrome (HLHS) before birth. As far as congenital heart diseases go, HLHS falls on the rarer end of the spectrum. The Heart Institute collaborates with the CFCC through the Fetal Cardiology Program.

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Lantheus Announces the FDA Approval of DEFINITY as Ultrasound Enhancing Agent for Use in Certain Pediatric Cardiovascular Patients

DAIC

Food and Drug Adminstration (FDA) has approved DEFINITY (Perflutren Lipid Microsphere) as an ultrasound enhancing agent for use in pediatric patients with suboptimal echocardiograms, including those who have undergone heart transplant, or have Kawasaki disease or a congenital cardiovascular anomaly.

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Arrhythmias in children undergoing orthotopic heart transplantation

Frontiers in Cardiovascular Medicine

Introduction Heart transplantation (HT) is the only treatment option in children with heart failure secondary to cardiomyopathies and non-reparable congenital heart diseases. We did not identify significant risk factors for arrhythmias post-HT.

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Abstract TP261: Stroke in pediatric heart transplant patients

Stroke Journal

Introduction:Pediatric heart transplant (PHT) recipient survival has improved. Yet, neurologic morbidity related to heart failure and its treatment persist. CHD was the pre-PHT diagnosis in 21(62%) of stroke Pts, cardiomyopathy in 12(35%) and acquired heart disease in 1(3%).

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Abstract 4146466: Targeting Gut Microbiota-Derived Kynurenine to Predict and Protect the Remodeling of the Pressure Overloaded Young Heart

Circulation

Background:Without timely intervention, pressure-overloading left ventricular (poLV) remodeling may become progressive and readily degenerate into heart failure. Kyn is a pathological signal from an altered gut microbiota to activates AHR and its gene targets in poLV remodeling heart, promoting hypertrophy and fibrosis in respective cells.

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Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study

Circulation: Arrhythmia and Electrophysiology

This study aimed to investigate the early and late efficacy, survival, and safety of CRT in patients with tetralogy of Fallot.METHODS:Data were analyzed from an observational, retrospective, multicenter cohort, initiated jointly by the Pediatric and Congenital Electrophysiology Society and the International Society of Adult Congenital Heart Disease.