article thumbnail

Researchers Link Infant Heart Defects, Childhood Cancer

DAIC

tim.hodson Mon, 03/17/2025 - 14:56 March 17, 2025 Being born with a heart defect may be associated with an increased cancer risk for babies and their moms, according to new research published today in the American Heart Associations flagship journal Circulation. Researchers analyzed health information about more than 3.5 In the U.S.,

Cancer 52
article thumbnail

Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study

Frontiers in Cardiovascular Medicine

BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemic traits.

article thumbnail

Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

dementia and Alzheimer’s) can be assessed using polygenic risk scores, which aggregate the effects of numerous genetic variants to estimate genetic predisposition. Offsetting a high genetic predisposition might require a bit more focus and attention to optimizing your cardiorespiratory fitness. Moderate: 24.1–31.1

article thumbnail

Genetic predisposition to sedentary behavior increases the risk of cardiovascular diseases, finds study

Medical Xpress - Cardiology

Researchers have shown for the first time that genetic predisposition to sedentary behavior is associated with a higher risk of developing the most common cardiovascular diseases. A high genetic predisposition to sedentary behavior can increase the risk of cardiovascular diseases by up to 20%.

article thumbnail

Physiology Friday November Recap

Physiologically Speaking

The researchers investigated how various types of incidental and intermittent activity influence cardiovascular event risk, particularly when combined with varying levels of sedentary time. The inevitable conclusion for our training is that we need both low- and high-intensity training to truly reach our peak potential.

article thumbnail

Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association

Circulation

Over the past decade, new research has advanced scientific knowledge of neurodevelopmental trajectories, factors that increase neurodevelopmental risk, and neuroprotective strategies for individuals with congenital heart disease. Circulation, Ahead of Print.

article thumbnail

Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

Genetic predispositions have been associated with post-subarachnoid hemorrhage cognitive outcomes and emphasize a role for personalized care strategies. The major processes involved in such decline include early brain injury, delayed cerebral ischemia, neuroinflammation, superficial siderosis, and hydrocephalus.