Genetic predisposition and Outcomes - Cardiovascular Update

Midlife Choices May Offset Genetic Risk for Dementia, Stroke, Late-Life Depression

Med Page Today

NOVEMBER 8, 2024

(MedPage Today) -- Healthier lifestyle behaviors in midlife were linked with better outcomes in people with genetic predisposition for age-related brain diseases, longitudinal data from the U.K. Biobank showed. Over about 12 years of follow-up.

Genetic predisposition

Genetic predisposition Dementia Strokes Stroke

Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges

Circulation: Heart Failure

MARCH 14, 2025

About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.

Genetic predisposition

Genetic predisposition Heart Failure Biomarkers Circulation

The Role of Genetics in Heart Disease: Can You Prevent It?

MIBHS

FEBRUARY 28, 2025

Heart disease remains one of the leading causes of death worldwide, often attributed to a mix of lifestyle choices, environmental factors, and genetic predispositions. While you can’t change your genetic code, having a family history of heart disease does not mean your fate is sealed.

Genetic predisposition

Genetic predisposition Heart Disease Cholesterol Blood Pressure

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association

Circulation

FEBRUARY 22, 2024

This American Heart Association scientific statement serves as an update to the 2012 statement on the evaluation and management of neurodevelopmental outcomes in children with congenital heart disease.

Congenital Heart Disease

Congenital Heart Disease Congenital Heart Disease Genetic predisposition

Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association

Stroke Journal

FEBRUARY 1, 2024

We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence and providing suggestions on the diagnostic evaluation, treatment approaches, and outcomes. The diagnosis can be challenging both clinically and radiologically.

Genetic predisposition

Genetic predisposition Outcomes Thrombolysis Congenital

Physiology Friday November Recap

Physiologically Speaking

DECEMBER 2, 2024

This study emphasizes how exercise intensity and volume contribute differently to physiological adaptations, depending on the desired outcome and the individual’s fitness level. The inevitable conclusion for our training is that we need both low- and high-intensity training to truly reach our peak potential. hours/day), moderate (10.2–11.4

Physiology

Physiology Exercise Dementia Genetic predisposition

PO-06-052 THE OCCURRENCE OF VENTRICULAR SEPTAL SCARRING, HEART FAILURE, AND GENETIC VARIANTS IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY AND ARRHYTHMIA: RESULTS FROM THE PHOENIX CARDIAC GENETIC REGISTRY (PCGR).

HeartRhythm

APRIL 30, 2024

Genetic predisposition to ventricular scarring is associated with heart failure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.

Genetic predisposition

Genetic predisposition Heart Failure Arrhythmia Cardiomyopathy

PO-06-050 THE ASSOCIATION BETWEEN VENTRICULAR ABLATION, SEPTAL SCARRING, AND GENETIC VARIANTS: RESULTS FROM THE PHOENIX CARDIAC GENETIC REGISTRY (PCGR).

HeartRhythm

APRIL 30, 2024

Genetic predisposition to septal scarring can result in ventricular arrhythmia and poorer ablation outcomes. There is a need to better define these genetic variants to understand clinical implications. Many commonly occurring variants continue to be described as variants of uncertain significance (VUS).

Genetic predisposition

Genetic predisposition Ablation Arrhythmia Outcomes

Atrial Fibrillation in Black American Patients: A Review of Genetics, Risk Factors, and Outcomes

HeartRhythm

NOVEMBER 5, 2024

Data pertaining to the American Heart Association Life’s Simple 7 (LS7) health metrics show that Black Americans have suboptimal LS7 scores compared to White Americans on average despite lower genetic predisposition to AF.

Atrial Fibrillation

Atrial Fibrillation Risk Factors Genetic predisposition Cardiovascular Disease

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Frontiers in Cardiovascular Medicine

JUNE 25, 2024

Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases.

Cardiovascular Disease

Cardiovascular Disease Genetic predisposition Pharmacology Cancer

Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

MARCH 4, 2025

Genetic predispositions have been associated with post-subarachnoid hemorrhage cognitive outcomes and emphasize a role for personalized care strategies. These have emerging treatments that offer promise for the mitigation of effects such as inflammation, iron chelation, and microvascular dysfunction.

Hemorrhage

Hemorrhage Genetic predisposition Genetic Markers Quality of Life

How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Dr. Paddy Barrett

APRIL 26, 2024

Yes, there is a genetic predisposition at play. But they don’t guarantee the outcome. We know that getting most of these same factors in line early in life can mean avoiding type 2 diabetes entirely 4. For sure. ( I know because I have some of those genes ). But those genes are probabilistic, not deterministic.

Heart Disease

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition

Why Interoperability is Key to Personalized Treatment Plans in Cardiology

GEMMS

SEPTEMBER 27, 2024

Cardiovascular diseases vary widely, so personalized care is critical for improving outcomes and patient satisfaction. Personalized treatment plans consider genetic predispositions, lifestyle, and comorbidities, ensuring that each patient receives the most effective care.

Technology

Technology Genetic predisposition Patient Care Education

Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

Circulation

DECEMBER 17, 2023

The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4.4

Genetic predisposition

Genetic predisposition Cardiomyopathy Sudden Cardiac Death Heart Failure

Lifestyle Risk Factors Predict Coronary Calcification among Male Endurance Athletes

Physiologically Speaking

DECEMBER 17, 2024

Therefore, athletes, especially those with genetic predispositions or cardiovascular symptoms, should monitor their health history, risk factors, and exercise intensity carefully to balance performance and long-term heart health. Instead, it reveals that a mix of traditional and non-traditional risk factors drives CAC development.

Risk Factors

Risk Factors Genetic predisposition Plaque Exercise

Midlife Choices May Offset Genetic Risk for Dementia, Stroke, Late-Life Depression

Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges

The Role of Genetics in Heart Disease: Can You Prevent It?

Webinars

Neurodevelopmental Outcomes for Individuals With Congenital Heart Disease: Updates in Neuroprotection, Risk-Stratification, Evaluation, and Management: A Scientific Statement From the American Heart Association

Treatment and Outcomes of Cervical Artery Dissection in Adults: A Scientific Statement From the American Heart Association

Physiology Friday November Recap

PO-06-052 THE OCCURRENCE OF VENTRICULAR SEPTAL SCARRING, HEART FAILURE, AND GENETIC VARIANTS IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY AND ARRHYTHMIA: RESULTS FROM THE PHOENIX CARDIAC GENETIC REGISTRY (PCGR).

PO-06-050 THE ASSOCIATION BETWEEN VENTRICULAR ABLATION, SEPTAL SCARRING, AND GENETIC VARIANTS: RESULTS FROM THE PHOENIX CARDIAC GENETIC REGISTRY (PCGR).

Atrial Fibrillation in Black American Patients: A Review of Genetics, Risk Factors, and Outcomes

Effects of vitamin D signaling in cardiovascular disease: centrality of macrophage polarization

Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Why Interoperability is Key to Personalized Treatment Plans in Cardiology

Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy

Lifestyle Risk Factors Predict Coronary Calcification among Male Endurance Athletes

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