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Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study

Frontiers in Cardiovascular Medicine

BackgroundThis Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemic traits.

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Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review

Cardiovascular Diabetology

Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated w.

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Lifestyle Risk Factors Predict Coronary Calcification among Male Endurance Athletes

Physiologically Speaking

While CAC is typically associated with traditional risk factors such as age, hypertension, and smoking, paradoxically elevated CAC scores have been observed in male endurance athletes despite their otherwise healthy profiles. Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease.

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Genetically predicted lipids mediate the association between intrahepatic cholestasis of pregnancy and cardiovascular disease

Frontiers in Cardiovascular Medicine

However, the influence of ICP on cardiovascular disease (CVD), including hypertension (HTN) and coronary artery disease (CAD), has not been thoroughly investigated.MethodsThis study explores the causal relationship between ICP and CVD (HTN, CAD) using Mendelian Randomization (MR). 4% of pregnancies.

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Education and cardiovascular diseases: a Mendelian randomization study

Frontiers in Cardiovascular Medicine

Results Our study identified a genetic predisposition associated with an additional 3.6 Causality was assessed using the inverse-variance weighted (IVW), ME-Egger regression, and weighted median methods. Sensitivity analyses, including heterogeneity and pleiotropy tests, were conducted to ensure the robustness of our findings.

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Why Interoperability is Key to Personalized Treatment Plans in Cardiology

GEMMS

The Need for Personalization in Cardiology Cardiovascular health is inherently complex, with conditions ranging from hypertension to heart failure requiring specific treatment plans. Personalized treatment plans consider genetic predispositions, lifestyle, and comorbidities, ensuring that each patient receives the most effective care.

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A review of the risk and precipitating factors for spontaneous coronary artery dissection

Frontiers in Cardiovascular Medicine

Traditional risk factors are rare in patients with SCAD, except for hypertension. In recent years, the genetic predisposition for SCAD is also recognized as a predisposing factor. The high frequency is particularly observed during pregnancy and in the peripartum period (first week).

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