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Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.

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Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysis

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundObservational studies have shown a significant association between immune cells and heart failure (HF).

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PO-06-052 THE OCCURRENCE OF VENTRICULAR SEPTAL SCARRING, HEART FAILURE, AND GENETIC VARIANTS IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY AND ARRHYTHMIA: RESULTS FROM THE PHOENIX CARDIAC GENETIC REGISTRY (PCGR).

HeartRhythm

Genetic predisposition to ventricular scarring is associated with heart failure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.

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Education and cardiovascular diseases: a Mendelian randomization study

Frontiers in Cardiovascular Medicine

Results Our study identified a genetic predisposition associated with an additional 3.6 years of education, which significantly reduced the risk of various CVDs. However, the impact of education on pulmonary embolism remains inconclusive.

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Why Interoperability is Key to Personalized Treatment Plans in Cardiology

GEMMS

The Need for Personalization in Cardiology Cardiovascular health is inherently complex, with conditions ranging from hypertension to heart failure requiring specific treatment plans. Given the vast array of patient profiles and varying conditions, more than a one-size-fits-all approach is needed.

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Alcohol and Heart Health: Understanding the Impact of Drinking on Your Heart

MIBHS

Studies show that repeated binge drinking can contribute to spikes in blood pressure, increasing the likelihood of stroke, heart attack, and heart failure. Heart Muscle Damage and Heart Failure The impact of drinking alcohol on the heart muscle is another critical area of concern.

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The Role of Genetics in Heart Disease Risk

AMS Cardiology

It encompasses a range of conditions, including coronary artery disease, heart failure and arrhythmias. While lifestyle factors such as diet, exercise and smoking play a significant role in the development of heart disease, genetics also contribute substantially.