Cardiovascular Diabetology

DECEMBER 20, 2024

Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated w.

Genetic predisposition 64

Genetic predisposition Cardiovascular Disease Diabetes Hypertension 64

Medical Xpress - Cardiology

NOVEMBER 18, 2024

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD).

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Genetic Markers Genetic predisposition Heart Disease Coronary Artery Disease 65

Physiologically Speaking

NOVEMBER 22, 2024

dementia and Alzheimer’s) can be assessed using polygenic risk scores, which aggregate the effects of numerous genetic variants to estimate genetic predisposition. Offsetting a high genetic predisposition might require a bit more focus and attention to optimizing your cardiorespiratory fitness.

Physiology 111

Physiology Dementia Genetic predisposition Exercise 111

HCPLive

DECEMBER 4, 2024

Panelists discuss how elevated LDL-C levels significantly contribute to ASCVD development through both modifiable lifestyle factors and genetic predisposition, making it a critical target for cardiovascular disease prevention.

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Genetic predisposition Cardiovascular Disease 52

American College of Cardiology

NOVEMBER 11, 2024

What is the causality between genetic predisposition to gestational diabetes mellitus (GDM) and the risk of cardiovascular disease (CVD)?

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Genetic predisposition Diabetes Cardiovascular Disease Article 49

Physiologically Speaking

DECEMBER 17, 2024

Therefore, athletes, especially those with genetic predispositions or cardiovascular symptoms, should monitor their health history, risk factors, and exercise intensity carefully to balance performance and long-term heart health. Instead, it reveals that a mix of traditional and non-traditional risk factors drives CAC development.

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Risk Factors Genetic predisposition Plaque Exercise 105

HeartRhythm

APRIL 30, 2024

Atrial fibrillation is the most prevalent sustained cardiac arrhythmia and an important risk factor for ischemic stroke resulting in a fivefold increased stroke risk. The clinical utility of polygenic risk scores for ischemic stroke prediction among atrial fibrillation patients has not yet been established.

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Atrial Fibrillation Genetic predisposition Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Cervical artery dissection occurs as a result of the interplay among risk factors, minor trauma, anatomic and congenital abnormalities, and genetic predisposition. The writing group chair and vice chair compiled the manuscript and obtained writing group members’ approval.

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Genetic predisposition Outcomes Thrombolysis Congenital 75

Circulation

FEBRUARY 22, 2024

It also includes an updated algorithm for referral, evaluation, and management of individuals at high risk.

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Congenital Heart Disease Congenital Heart Disease Genetic predisposition 75

HeartRhythm

APRIL 30, 2024

Genetic predisposition to ventricular scarring is associated with heart failure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.

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Genetic predisposition Heart Failure Arrhythmia Cardiomyopathy 40

HeartRhythm

APRIL 30, 2024

Genetic predisposition to septal scarring can result in ventricular arrhythmia and poorer ablation outcomes. There is a need to better define these genetic variants to understand clinical implications. Many commonly occurring variants continue to be described as variants of uncertain significance (VUS).

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Genetic predisposition Ablation Arrhythmia Outcomes 40

Frontiers in Cardiovascular Medicine

JUNE 25, 2024

Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases.

Cardiovascular Disease 52

Cardiovascular Disease Genetic predisposition Pharmacology Cancer 52

Frontiers in Cardiovascular Medicine

APRIL 29, 2024

mediation effect.DiscussionThe results underscore the genetic predisposition of ICP to elevate CVD risk and the critical mediating role of lipid levels, emphasizing the need for vigilant lipid monitoring and early intervention in individuals with ICP.

Cardiovascular Disease 52

Cardiovascular Disease Genetic predisposition Coronary Artery Disease Hypertension 52

AMS Cardiology

OCTOBER 11, 2023

While lifestyle factors such as diet, exercise and smoking play a significant role in the development of heart disease, genetics also contribute substantially. Genetic Predisposition Genetic predisposition to heart disease is a reality for many individuals.

Heart Disease 52

Heart Disease Genetic predisposition Diet Genetic Markers 52

HeartRhythm

NOVEMBER 5, 2024

Data pertaining to the American Heart Association Life’s Simple 7 (LS7) health metrics show that Black Americans have suboptimal LS7 scores compared to White Americans on average despite lower genetic predisposition to AF.

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Atrial Fibrillation Risk Factors Genetic predisposition Outcomes 40

Heart BMJ

APRIL 15, 2024

Background The relationship between combined genetic predisposition and lifestyle and the risk of incident atrial fibrillation (AF) is unclear. Therefore, we aimed to assess a possible interaction between lifestyle and genetics on AF risk.

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Atrial Fibrillation Genetic predisposition Risk Factors Diet 52

Frontiers in Cardiovascular Medicine

FEBRUARY 14, 2024

Results Our study identified a genetic predisposition associated with an additional 3.6 Causality was assessed using the inverse-variance weighted (IVW), ME-Egger regression, and weighted median methods. Sensitivity analyses, including heterogeneity and pleiotropy tests, were conducted to ensure the robustness of our findings.

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Education Cardiovascular Disease Peripheral Arterial Disease Genetic predisposition 49

Circulation

NOVEMBER 11, 2024

The SRPS is hypothesised to facilitate early detection and inform targeted interventions.Aim:The primary aim is to conceptualise and outline the SRPS, which categorises individuals into risk categories based on a point system reflecting genetic predispositions, clinical symptoms, dietary habits, and response to treatments.

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Genetic predisposition Lipid disorders Innovation Risk Factors 40

Dr. Paddy Barrett

APRIL 26, 2024

Yes, there is a genetic predisposition at play. But I am saying that even if you have developed type 2 diabetes, which is a major driver of risk, there is still a huge amount that can be done to reduce future risk. But why wait? For sure. ( I know because I have some of those genes ). They set the odds.

Heart Disease 97

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 97

Circulation: Arrhythmia and Electrophysiology

MARCH 5, 2024

The highest HRs (95% CIs) of AF were observed for participants at high genetic risk who consumed >2 L/wk of ASB (HR, 3.51 [95% CI, 2.94–4.19]), 4.19]), and the lowest HR were observed for those at low genetic risk who consumed ≤1 L/wk of PJ (HR, 0.77 [95% CI, 0.65–0.92]).

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Atrial Fibrillation Genetic predisposition Diet Electrophysiology 40

Wellnest

AUGUST 24, 2023

By adopting a heart-healthy diet, engaging in regular physical activity, managing stress, avoiding smoking, and controlling blood pressure and cholesterol levels, we can mitigate genetic predispositions' impact and reduce our overall risk of cardiovascular disease. Myth #3: Heart diseases only affect men.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Genetic predisposition 52

Physiologically Speaking

DECEMBER 2, 2024

This study examined the relationship between cardiorespiratory fitness and the risk of developing neurodegenerative diseases, such as dementia and Alzheimer’s, particularly in individuals with a high genetic predisposition.

Physiology 59

Physiology Exercise Dementia Genetic predisposition 59

GEMMS

SEPTEMBER 27, 2024

Personalized treatment plans consider genetic predispositions, lifestyle, and comorbidities, ensuring that each patient receives the most effective care. The Need for Personalization in Cardiology Cardiovascular health is inherently complex, with conditions ranging from hypertension to heart failure requiring specific treatment plans.

Technology 52

Technology Genetic predisposition Patient Care Education 52

Stroke Journal

FEBRUARY 1, 2024

Background:Diabetes is a highly heritable stroke risk factor with numerous known genetic risk variants. However, the role of these genetic risk variants in the development of cerebrovascular disease in Native Hawaiians remains unknown. Genetic predisposition to diabetes was associated with a 23% higher risk of diabetes (OR 1.23, CI 1.01-1.51;

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Genetic predisposition Diabetes Stroke Strokes 40

Circulation

DECEMBER 17, 2023

The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4.4

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Genetic predisposition Cardiomyopathy Sudden Cardiac Death Exercise 77

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2023

In recent years, the genetic predisposition for SCAD is also recognized as a predisposing factor. The precipitating factors are also different in women (emotional stress) compared with those in men (physical stress).

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SCAD Genetic predisposition Risk Factors Chest Pain 88

Stroke Journal

FEBRUARY 1, 2024

We used multivariate logistic and Cox Proportional Hazards regressions, as appropriate, to assess the relationship between genetic predisposition to hypertension and both uncontrolled BP and incident stroke.Results:The discovery stage included 110,892 participants (mean age 58, female sex 58%). 1.18) and 30% (OR 1.30, 95%CI 1.24-1.36)

Blood Pressure 40

Blood Pressure Genetic predisposition Stroke Strokes 40

Circulation: Genomic and Precision Medicine

NOVEMBER 29, 2024

The female-specific positive association of PGSMDwith CAD risk was replicated in BioVU.CONCLUSIONS:Genetic predisposition to MD confers a greater risk of CVDs in females versus males, even in the absence of any depression diagnosis.

Cardiovascular Disease 40

Cardiovascular Disease Genetic predisposition Coronary Artery Disease Risk Factors 40