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Despite proven benefits in reducing morbidity and mortality, many heartfailure (HF) patients do not receive optimal guideline-directed medical therapy (GDMT). The 2021 European Society of Cardiology guidelines recommend guideline-directed medical therapy (GDMT) for patients with HF with reduced ejection fraction (HFrEF).
RELIEVE-HF investigators evaluated the efficacy and safety of the V-wave interatrial shunt system in patients with heartfailure. The primary endpoint was a composite of all-cause mortality, left ventricular assist device (LVAD)/heart transplantation, HF hospitalizations, worsening HF, and KCCQ score changes. April 6, 2024.
Current Role of Digoxin in HeartFailure as Per Guidelines and DIGIT-HF trial of Digitoxin Use of digoxin in heartfailure has come down markedly over the past decades due to concerns of toxicity and availability of more effective medications. Eur Heart J. Erratum in: Eur Heart J. Eur J Heart Fail.
Introduction The diagnostic and therapeutic arsenal for heartfailure with preserved ejection (HFpEF) has expanded. With novel therapies (eg, sodium-glucose co-transporter 2 inhibitors) and firmer recommendations to optimise non-cardiac comorbidities, it is unclear if outpatient HFpEF models can adequately deliver this.
The Sleep Heart Health Study found that obstructive sleep apnea with excessive daytime sleepiness triples the chance of heartfailure and doubles the risk of a heart disease event. The same subtype was associated with increased risk of new occurrence of heart disease. Wait before taking it so lightly.
Autonomic dysfunction caused by spinal cord injury is associated with abnormalities in blood pressure, heart rate variability, arrhythmias and blunted cardiovascular response to exercise which can limit the capacity to perform physical activity [1]. Survivors with severe disability had the highest risk. Am J Phys Med Rehabil. PMID: 17251696.
Mark Schuuring discuss the results of the ADMINISTER2 trial ( NCT05413447 ) which investigated whether the use of digital consults (DCs) could enhance the adoption of guideline-directed medical therapy (GDMT) in patients with heartfailure and reduced ejection fraction (HFrEF).
15.3), 3.3% (n = 18) of patients died, with heartfailure events most common in RCM patients (36.0%). Genetic Associations: Genetic testing was conducted in 67.8% (n = 414) of patients, revealing pathogenic or likely pathogenic variants in 60.4% (n = 250) of tested cases. Familial disease was identified in 47.3% (n = 253) of patients.
In a recent study published in Circulation: HeartFailure , researchers analyzed a large group of individuals with various cardiopulmonary diseases who had undergone right heart catheterization. year follow-up, those with right ventricular dysfunction faced an increased risk of mortality and heartfailure hospitalization.
When thyroid function is increased, heart rate increases and the work load of the heart increases. In severe cases heartfailure may occur. While in low output heartfailure the extremities are cold, in high output failure due to increased thyroid function, the extremities of the limbs are warm.
CRT is used in heartfailure with reduced ejection fraction. According to the Universal Definition and Classification of HeartFailure, heartfailure with reduced ejection fraction has left ventricular ejection fraction of 40% or less. CRT stands for cardiac resynchronization therapy.
Large VSDs can be associated with heartfailure in infancy and may need surgery. Perimembranous VSD is the commonest type of ventricular septal defect noted in children. There is a good chance of spontaneous closure of those detected in early childhood.
AF-CHF trial in those with AF and congestive heartfailure also failed to show any advantage for the rhythm control strategy [3]. Overall, it appears that rhythm control strategy in AF may be better in those with heartfailure and in those with associated cardiovascular conditions and early AF.
Chadi Alraies discusses some of the important trials presented at the European Society of Cardiology 2024 congress. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ESC 2024 Highlights appeared first on Cardiology Update.
An important limitation is their potential cardiotoxicity which can cause heartfailure at varying time intervals, even decades later. Anthracyclines are an important group of medications useful in the treatment of solid tumours and hematological malignancies.
Some of them may develop heartfailure, arrhythmias, thromboembolic events and even sudden cardiac death rarely. Blood flow into and out of these recesses can provide a spectacular view on colour Doppler echocardiography, almost looking like flames of fire near the apex, in the apical four chamber view. Reference Thilde O.
That is due to impaired flow through the coronary microcirculation and is associated with higher mortality as well as chance for left ventricular dysunction and heartfailure. In the initial era of primary PCI, angiographic myocardial blush was taken as a surrogate of effective myocardial reperfusion.
But potential beneficial association was noted between regular use of fish oil supplements and transitions from atrial fibrillation to myocardial infarction, atrial fibrillation to death and heartfailure to death.
Chadi Alraies discusses the top impactful trials presented at the 2024 American College of Cardiology conference. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ACC 2024 Highlights appeared first on Cardiology Update.
Extra fluid in the body can occur due to failure of heart, kidneys, liver and rarely due to other causes. In heartfailure, the extra fluid is due to inability of the heart to pump out blood well.
Lower blood pressures mean lower workload for the heart and lower risk of left ventricular hypertrophy and heartfailure. Though blood pressure rises progressively with increasing exercise, it reduces the resting blood pressure in the long run. High density lipoprotein cholesterol in the blood increases with regular exercise.
Chadi Alraies discusses highlights from the American Heart Association (AHA) Scientific Sessions 2023, which were held in Philadelphia, Pennsylvania (PA), on November 11-13, 2023. There were many important developments in presented in key clinical trial presentations and publications stemming from the AHA Scientific Sessions 2023.
The primary outcome measured was a composite of myocardial infarction, revascularisation, hospitalisation for heartfailure, stroke, or cardiovascular death, assessed over a median follow-up of 3.4 Key Findings – Blood Pressure Levels: The mean systolic blood pressure during follow-up was 119.1 mm Hg in the standard group.
But while compressing here in a patient with heartfailure, it can elicit pain because there could be tender hepatomegaly in patients with heartfailure. That occurs in right heartfailure and constrictive pericarditis. Then, these are the important waves to be looked at in the jugular venous pulsation.
Some of the reasons cited are that, those who are likely to develop ventricular arrhythmias, that is basically those with left ventricular dysfunction after myocardial infarction, are also more prone for heartfailure deaths as well as higher ischemic burden, soon after myocardial infarction. That is one reason.
Investigators assessed if empagliflozin could lower the risk of hospitalization for heartfailure (HF) or death from cardiovascular disease (CVD). EMPACT-MI 1 ( NCT04509674 ) studied the effects of empagliflozin in patients who have experienced myocardial infarction (MI).
Ebstein’s anomaly may present with a murmur for evaluation in the pediatric age group or in adults with arrhythmias or heartfailure with cyanosis and exercise intolerance. Auscultatory hallmarks of Ebstein’s anomaly the multiple heart sounds and a superficial scratchy precordial murmur.
Patients in the aficamten group with LVEF less than 50% did not need interruption of treatment or have exacerbation of heartfailure, indicating the shallow dose-response relationship [2].
They have heartfailure sometimes. So they do badly, but it develops only very late and in very few also. There are several persons in sixth and seventh decade, having ASD, with still left to right shunt. Another difference is that, right atrium is grossly enlarged in ASD. It produces cardiomegaly on X-ray in ASD Eisenmenger.
One situation is decompensated advanced systolic heartfailure with large left ventricle. Measurement of E’ is useful in differentiation of pseudo normalization in the mitral inflow from the normal pattern. There are also limitations for E/E’ in the assessment of LV diastolic dysfunction.
For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post TCT 2023 Highlights appeared first on Cardiology Update. Dr. Chadi Alraies provides an overview of the top highlights from TCT 2023.
Contrast enhanced magnetic resonance imaging Delayed enhancement on contrast enhanced MRI is useful in documenting fibrosis in HCM, which is a predictor of systolic dysfunction and has a relation to heartfailure symptoms.
There are seen in heartfailure when the lung is water loaded, with interstitial fluid. Continuing repetitions of internal reflections can cause reverberation artefacts, typically in case of prosthetic valves. Ultrasound lung comets or B lines, also known as comet tail artefacts are also a type of reverberation artefacts.
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