European Journal of Heart Failure

DECEMBER 7, 2023

ABSTRACT Background Left atrial (LA) myopathy is increasingly recognized as an important phenotypic trait in heart failure (HF) with preserved ejection fraction (HFpEF). There were 94 patients with events over a median follow-up of 2.9 (IQR 2.92, p = 0.01).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Exercise Atrial Fibrillation 40

JAMA Cardiology

AUGUST 13, 2024

This randomized clinical trial investigates the effects of verinurad on exercise capacity and symptoms in patients with heart failure with preserved ejection fraction (HFpEF) and elevated serum uric acid levels.

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Preserved Ejection Fraction Heart Failure Exercise 62

Circulation: Heart Failure

OCTOBER 23, 2023

BACKGROUND:Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive. Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Exercise 40

Circulation: Heart Failure

DECEMBER 6, 2024

BACKGROUND:In heart failure, sympathetic excess and exercise intolerance impair quality of life. In heart failure with reduced ejection fraction, exercise stimulates a reflex increase in muscle sympathetic nerve activity (MSNA) that relates inversely to peak oxygen uptake (VO2peak).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Heart Failure Quality of Life 40

European Journal of Heart Failure

FEBRUARY 5, 2025

Beta-blockers are commonly used in patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF). However, there is recent concern that this type of medication may be harmful in patients with HFmrEF/HFpEF, causing exercise intolerance possibly due to exacerbation of chronotrophic incompetence.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Outcomes Atrial Fibrillation 40

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Pulmonary vascular resistance at rest and exercise decreased with higher BMI.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Obesity Heart Failure BMI 40

Circulation

DECEMBER 7, 2023

BACKGROUND:Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction. Dapagliflozin did not improve these outcomes in patients with HF with preserved ejection fraction. 95% CI, 0.00, 8.3;P=0.058).

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Preserved Ejection Fraction Heart Failure Exercise Cardiomyopathy 84

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Aims Preventive strategies for heart failure (HF) with preserved ejection fraction (HFpEF) include pharmacotherapies and lifestyle modifications. Thus, we evaluated the association between CRF and HFpEF incidence.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Myocardial Infarction Article 40

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundPulmonary hypertension (PH) is highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF), and it is a strong predictor of adverse outcomes. The patients underwent invasive cardiac catheterization and simultaneous echocardiography at rest and during exercise.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Pulmonary Heart Failure Hypertension 40

Journal of the American Heart Association

FEBRUARY 14, 2024

Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF).We Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF).We

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Blood Pressure Obesity 40

Circulation

NOVEMBER 17, 2024

Background: Patients with heart failure, a preserved ejection fraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure. Circulation, Ahead of Print. The broad spectrum of effects was reflected in benefits on the hierarchical composite (win ratio 1.63, 95%CI, 1.17, 2.28;P=0.004).Conclusions:

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Obesity Quality of Life 40

Journal of the American Heart Association

MARCH 3, 2025

Journal of the American Heart Association, Ahead of Print.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Exercise 40

DAIC

APRIL 22, 2024

RELIEVE-HF failed to meet its primary efficacy endpoint and did not reduce heart failure events or improve quality of life in heart failure patients with a preserved ejection fraction (HFpEF).

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Preserved Ejection Fraction Quality of Life Heart Failure Pacemaker 105

European Journal of Heart Failure

DECEMBER 29, 2023

Abstract Aims We aim to clarify the extent to which cardiac and peripheral impairments to oxygen delivery and utilization contribute to exercise intolerance and risk for adverse events, and how this relates to diversity and multiplicity in pathophysiological traits. Hemodynamics and oxygen transport responses were compared. L/min versus 2.8

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Heart Failure Pulmonary 40

Heart BMJ

FEBRUARY 12, 2024

Learning objectives To understand the importance of exercise and physical activity in the general management and well-being of people with heart failure (HF). To understand the key principles of exercise training prescription in people with HF. cross-ref type="bib".

Exercise 40

Exercise Heart Failure Preserved Ejection Fraction Pharmacology 40

Circulation

NOVEMBER 11, 2023

Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. mg improved symptoms, physical limitations and exercise function, and reduced inflammation and body weight. Circulation, Ahead of Print.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Quality of Life Obesity Heart Failure 40

Circulation: Heart Failure

DECEMBER 1, 2023

Circulation: Heart Failure, Ahead of Print.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Exercise Circulation 40

DAIC

APRIL 3, 2024

Featured topics will include in-depth sessions covering non-statin lipid lowering therapies, heart failure with preserved ejection fraction, viability, imaging modalities for the assessment of coronary artery disease, and antiplatelet therapy after coronary stenting.

Education 105

Education Preserved Ejection Fraction Coronary Artery Disease Cardio Oncology 105

Circulation: Heart Failure

SEPTEMBER 12, 2023

BACKGROUND:Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. We defined HFpEF based on the presence of elevated left ventricular filling pressures at rest or during exercise. P<0.001).

Biomarkers 40

Biomarkers Obesity Exercise Preserved Ejection Fraction 40

Circulation: Heart Failure

DECEMBER 18, 2023

mm Hg with exercise (P<0.001). mm Hg with exercise (P<0.001). At peak exercise, RT was responsible for 64% (53%–76%) of end-diastolic pressure, whereas incomplete relaxation and stiffness accounted for the rest. mm Hg in HF with preserved ejection fraction patients and was also exacerbated by exercise.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Cardiomyopathy Heart Failure 40

The American Journal of Cardiology

FEBRUARY 8, 2024

Publication date: Available online 7 February 2024 Source: The American Journal of Cardiology Author(s): Lajjaben Patel, Matthew W Segar, Neil Keshvani, Vinayak Subramanian, Ambarish Pandey, Alvin Chandra

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Exercise 40

JAMA Cardiology

JULY 23, 2024

Among patients with heart failure with preserved ejection fraction (HFpEF), right ventricular (RV) dysfunction is strongly associated with an increased risk of morbidity and mortality.

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Preserved Ejection Fraction Heart Failure Pulmonary Exercise 41

Dr. S. Venkatesan MD

APRIL 18, 2024

It is prudent to understand, that even in systolic LV failure; it is the raised LVEDP that causes the symptoms and marks the limits of exercise capacity. Shah, author of Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction: The REDUCE LAP-HF II Randomized Clinical Trial.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Pulmonary Congenital Heart Disease VSD 40

Circulation

NOVEMBER 11, 2024

Introduction:Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure which is rapidly rising in incidence in the US today. After 5 weeks of the diet, HFD mice and their littermate controls underwent baseline exercise testing and echocardiograms.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Echocardiogram Exercise Diet 40

Circulation

DECEMBER 21, 2023

BACKGROUND:Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Circulation, Ahead of Print. Metabolism-induced systemic inflammation links comorbidities with HFpEF.

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Preserved Ejection Fraction Diet Heart Failure Exercise 45

Circulation

NOVEMBER 11, 2024

Intro:Drug Development for Heart failure with Preserved Ejection Fraction (HFpEF) is a major challenge facing cardiovascular research due to its complex pathophysiology and existence of comorbidities, leading to recognize distinct HFpEF phenogroups. HFD/L-NAME mice showed altered exercise capacity (p<0.05

Preserved Ejection Fraction 40

Preserved Ejection Fraction Hypertension Blood Pressure Obesity 40

DAIC

APRIL 9, 2024

Maron, MD “Our findings provide enthusiasm that a novel drug therapy with ninerafaxstat may provide nonobstructive HCM patients an opportunity to achieve a better quality of life by decreasing symptom burden and improving exercise capacity,” said Martin S. The study was funded by Imbria Pharmaceuticals, developer of ninerafaxstat.

Cardiomyopathy 52

Cardiomyopathy Quality of Life Chest Pain Preserved Ejection Fraction 52

DAIC

FEBRUARY 29, 2024

ET Murphy Ballroom 4 Comparison of an "Inclisiran First" Strategy with Usual Care in Patients With Atherosclerotic Cardiovascular Disease: Results From the VICTORION-INITIATE Randomized Trial Targeting Weight Loss to Personalize the Prevention of Type 2 Diabetes Once-weekly Semaglutide in Patients with Heart Failure With Preserved Ejection Fraction, (..)

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Cardiometabolic Health Congress

JULY 25, 2023

4] More recently, at least at the epidemiologic level, the obesity paradox has been confirmed in both heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), but also in those with coronary heart disease. [5, Carbone, Salvatore, et al. Future Cardiology 13.5

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

European Journal of Heart Failure

NOVEMBER 19, 2024

Muscle quality and cardiac function in heart failure with preserved ejection fraction (HFpEF) during exercise. Therefore, the study aimed to determine the relationship between locomotor MQ and cardiac function during exercise in HFpEF. MQ was calculated as peak watts divided by LL%. vs. 2.3 ± 0.6 W/%,

Preserved Ejection Fraction 40

Preserved Ejection Fraction Cardiac Function Exercise Heart Failure 40

European Journal of Heart Failure

DECEMBER 13, 2023

Venn diagram highlighting the main similarities and differences between heart failure with preserved ejection fraction (HFpEF) and aortic stenosis with preserved ejection fraction (ASpEF). This study aimed to provide a non-invasive, comparative analysis of ASpEF versus HFpEF at rest and during exercise.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Stenosis Aortic valve 40

Circulation

NOVEMBER 11, 2024

The primary outcomes were exercise capacity, diastolic function, and quality of life at baseline evaluation. After controlling for potential confounding variables, there were no differences in baseline exercise capacity [peak VO2 (mL/kg/min): 12.1 Patients were divided into two groups based on BB use at trial enrollment.

Quality of Life 40

Quality of Life Preserved Ejection Fraction Exercise Heart Failure 40

DAIC

JUNE 26, 2024

The analysis sought to determine whether phenotypic features and treatment effects of semaglutide vary by sex in obesity-related heart failure ( HF ) with preserved ejection fraction (HFpEF). Our study sheds light on these differences and the consistent benefits of semaglutide for women and men.”

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Preserved Ejection Fraction Obesity BMI Heart Failure 105

International Journal of Cardiovascular Sciences

OCTOBER 21, 2024

Santos Most Cited Article – Reduction in Hospitalization and Increase in Mortality Due to Cardiovascular Diseases during the COVID-19 Pandemic in Brazil Authors: Paulo Garcia Normando, José de Arimatéia Araujo-Filho, Gabriela de Alcântara Fonseca, Rodrigo Elton Ferreira Rodrigues, Victor Agripino Oliveira, Ludhmila Abrahão Hajjar, André Luiz (..)

Article 52

Article Preserved Ejection Fraction COVID-19 Heart Failure 52

Frontiers in Cardiovascular Medicine

DECEMBER 16, 2024

To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe Each patient performed exercise stress test and standard ultrasonic images were evaluated.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Heart Failure Hypertension 40

European Journal of Heart Failure

DECEMBER 30, 2024

HFpEF, heart failure with preserved ejection fraction. Whether left ventricular size predicts functional capacity in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. Data were validated in a cohort of HFpEF patients from San Paolo Hospital, Milan, Italy.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Outpatient Exercise 40