CardiacWire

AUGUST 14, 2024

Rivus Pharmaceuticals’ HU6 is showing promise as a future obesity-related HFpEF treatment, after topline results from its Phase 2a HuMAIN trial revealed valuable weight, symptom, and cardiometabolic improvements – without the risk of muscle loss. The post Rivus HU6 Shows Obesity-HFpEF Potential appeared first on Cardiac Wire.

Obesity 52

Obesity Diet Quality of Life Blood Pressure 52

Dr. Paddy Barrett

NOVEMBER 15, 2024

A study of almost 10,000 adults with obesity (BMI >30) who were evaluated for all LE8 factors and followed for over 7 years can give us some insight 1. Many people who are overweight or obese and who cannot reduce their weight often feel that no matter what they do, they are not able to reduce their future risk. The answer is yes.

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MIBHS

DECEMBER 29, 2023

Exercise and heart health— you’ve probably heard of the correlation before. Engaging in exercise can significantly contribute to maintaining a healthy heart and reducing the risk of cardiovascular diseases. By addressing these risk factors, exercise significantly lowers the risk of developing cardiovascular diseases.

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Exercise Blood Pressure Risk Factors Cardiovascular Disease 52

Dr. Paddy Barrett

JULY 19, 2024

So, I decided to track my calories, macros and exercise more carefully over the next few weeks, which soon got me to my target. The same holds true for exercise-based interventions. It's not that the exercise stopped working. It’s that people stopped exercising. Just like exercise is a tool. may be necessary.

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Medical Xpress - Cardiology

JANUARY 17, 2024

A robust body of evidence shows aerobic exercise can reduce risks, especially for people who are overweight or obese. Approximately one in three deaths in the U.S. is caused by cardiovascular disease, according to the U.S. Centers for Disease Control and Prevention.

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Cardiovascular Disease Research Obesity Exercise 80

Cardiometabolic Health Congress

JULY 25, 2023

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

American College of Cardiology

JANUARY 24, 2024

The goal of the CardioRACE trial was to evaluate different exercise strategies compared with control among patients with overweight/obesity.

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Exercise Obesity Article 42

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2024

Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is closely linked to metabolic dysfunctions, including obesity, diabetes, and dyslipidemia. Additionally, it calls for more basic studies and large-scale clinical trials to establish and refine evidence-based exercise guidelines specific to AF management.

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Atrial Fibrillation Exercise Pharmacology Obesity 40

Physiologically Speaking

DECEMBER 22, 2023

Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol. link] Of course, diet is an important component of metabolic health, but exercise also plays an indispensable role.

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Exercise Physiology Blood Pressure Cholesterol 52

Physiologically Speaking

DECEMBER 22, 2023

Clinically, about 1/3 of adults have metabolic syndrome — a cluster of conditions including abdominal obesity, high blood pressure, high blood glucose, high triglycerides, and low HDL cholesterol. link] Of course, diet is an important component of metabolic health, but exercise also plays an indispensable role.

Exercise 52

Exercise Physiology Blood Pressure Cholesterol 52

Dr. Paddy Barrett

AUGUST 9, 2024

The 14 Factors Include: Hearing Loss High LDL cholesterol Less Education Traumatic Brain Injury Depression Social Isolation Hypertension Obesity Smoking Excess Alcohol Diabetes Physical Inactivity Air Pollution Visual Loss Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission When You Intervene Matters.

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Dementia Blood Pressure Obesity Cholesterol 108

HeartRhythm

APRIL 30, 2024

The obesity-HFpEF phenotype is a unique form of heart failure associated with elevated LA and RA pressures, cardiac remodelling and poor exercise capacity. The influence of this HFpEF phenotype amongst patients with AF is unknown.

Obesity 40

Obesity Exercise Heart Failure 40

DAIC

JUNE 18, 2024

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8

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Heart Disease Blood Pressure Stroke Strokes 105

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Echocardiography demonstrated increased CO with obesity, but not estimated right atrial (RA) pressure or E/e′. Overall, 60.9%

Preserved Ejection Fraction 40

Preserved Ejection Fraction Obesity Heart Failure BMI 40

Dr. Paddy Barrett

APRIL 5, 2024

It is a structured education and exercise program that helps people understand what has just happened to them and helps them get all the lifestyle and medical pieces together to reduce the future risk of a major heart event. Regular exercise and hitting LDL-C targets of <1.4 Share Reverse Coronary Artery Disease. Br J Gen Pract.

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Heart Disease Coronary Artery Disease Heart attacks Heart Attack 109

Dr. Paddy Barrett

APRIL 12, 2024

But for many people regular exercise at even moderate intensities will not be on the cards. More steps are linked to: Less obesity. Maybe you are one of the fortunate ones who loves to exercise at a high level and has managed to land in the top 2.5% occupation-related physical activity and their associations with obesity.

Quality of Life 120

Quality of Life Blood Pressure Exercise Chronic Disease 120

Dr. Paddy Barrett

AUGUST 30, 2024

At the bottom are the four pillars of a good lifestyle: exercise, nutrition, sleep and stress. Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. Obesity is one of the biggest global health concerns we face today. Obesity is also a key driver of risk for cardiovascular disease. Obesity (Silver Spring).

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Heart Disease Dementia Obesity Heart attacks 107

Dr. Paddy Barrett

DECEMBER 12, 2023

That’s what the field of obesity therapeutics feels like right now. What was once an area of healthcare that had few reliable interventions, this drug class has revolutionised the management of excess weight and obesity. Subscribe now 1 [link] 2 [link] 3 Retatrutide Phase 2 Obesity Trial Investigators. N Engl J Med.

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Obesity Heart attacks Heart Attack Diet 99

Circulation

NOVEMBER 17, 2024

Background: Patients with heart failure, a preserved ejection fraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure. Circulation, Ahead of Print. The broad spectrum of effects was reflected in benefits on the hierarchical composite (win ratio 1.63, 95%CI, 1.17, 2.28;P=0.004).Conclusions:

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Obesity Quality of Life 40

Dr. Paddy Barrett

MAY 24, 2024

The DPP is a year-long program involving multiple group coaching sessions that focuses primarily on improving: Nutrition Exercise Stress Management. However, for those who used both nutrition AND exercise as their strategy, the risk of death from any cause fell by 28% 5. ” Diabetes. Does weight loss work in these cases?

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Diabetes Diet BMI Exercise 98

Circulation

NOVEMBER 11, 2024

This study aims to establish the effect of an active lifestyle in paediatric Fontan patients, determine its relationship with body composition, exercise capacity, ventricle function and quality of life.Methods:30 Fontan patients were recruited. Overall BMI was normal, however 17% (5 of 30) were overweight or obese (Table 1).The

Quality of Life 40

Quality of Life Exercise Circulation Congenital Heart Disease 40

Circulation

NOVEMBER 11, 2023

Background:Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life. mg improved symptoms, physical limitations and exercise function, and reduced inflammation and body weight. mg or placebo for 52 weeks.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Quality of Life Obesity Heart Failure 40

Cardiometabolic Health Congress

JUNE 27, 2024

Competence in selecting treatments for long-term obesity management rose from 43% pre-test to 95% post-test. Neha Agarwal, PhD, Clinical Director at Cardiometabolic Health Congress , Informa Connect, recently presented significant findings at the 84th American Diabetes Association (ADA) Scientific Sessions.

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CME Diabetes Obesity Education 59

Circulation

JANUARY 22, 2025

Optimal NT-proBNP cut points for HFpEF rule out (optimizing sensitivity) and rule in (optimizing specificity) were derived and tested, stratified by obesity and atrial fibrillation. In our study, NT-proBNP provided little value in those with AF and dyspnea because the presence of AF is by itself a robust biomarker of HFpEF.

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Preserved Ejection Fraction Outpatient Heart Failure BMI 45

Physiologically Speaking

NOVEMBER 29, 2023

However, newer research has failed to replicate these findings, showing no performance enhancement in longer-duration endurance events with ketone esters and, in some cases, observing a negative impact on high-intensity exercise performance. What are ketone esters, also referred to as exogenous ketones? More on this later.

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Exercise Diet Physiology Obesity 52

Physiologically Speaking

NOVEMBER 29, 2023

However, newer research has failed to replicate these findings, showing no performance enhancement in longer-duration endurance events with ketone esters and, in some cases, observing a negative impact on high-intensity exercise performance. What are ketone esters, also referred to as exogenous ketones? More on this later.

Exercise 52

Exercise Diet Physiology Obesity 52

Dr. Paddy Barrett

AUGUST 16, 2024

Overweight/Obesity. Falling into the class of obesity with a BMI of greater than 30 makes this more likely, but so also does having excess visceral fat deposition with significant metabolic consequences at a BMI less than 30. So What Is The Efficacy Of Diet & Exercise For Weight Loss? ” here is what I tell them.

Obesity 52

Obesity Blood Pressure Diet Exercise 52

Circulation

NOVEMBER 11, 2024

Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) HFD/L-NAME mice showed altered exercise capacity (p&lt;0.05 l) for 8 weeks.

Hypertension 40

Hypertension Preserved Ejection Fraction Blood Pressure Obesity 40

Cardiometabolic Health Congress

JUNE 7, 2024

They highlighted that the non-HDL/HDL ratio is a better predictor of ASCVD and that triglycerides (TG) are a sensitive indicator of diet and exercise, emphasizing the importance of lifestyle factors in lipid management and cardiovascular risk reduction. The interplay of Obesity, Dyslipidemia, and CVD : Dr. Harold E.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

Physiologically Speaking

DECEMBER 15, 2023

On Monday, I posted a video summary of the recently released Scientific Statement by the American Heart Association (AHA) on resistance exercise training for cardiovascular health. Everyone knows that resistance exercise is important for building and maintaining muscle mass. We lift weights to build and maintain muscle.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

DECEMBER 15, 2023

On Monday, I posted a video summary of the recently released Scientific Statement by the American Heart Association (AHA) on resistance exercise training for cardiovascular health. Everyone knows that resistance exercise is important for building and maintaining muscle mass. We lift weights to build and maintain muscle.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Frontiers in Cardiovascular Medicine

APRIL 28, 2024

This finding was confirmed in populations without exercise habits, under 60 years of age, with normal blood pressure, and in non-obese groups. For each SD increment, MAP had the strongest association with NAFLD compared to SBP and DBP.

Blood Pressure 52

Blood Pressure Document Obesity Risk Factors 52

Wellnest

AUGUST 24, 2023

Unhealthy lifestyle habits, genetics, obesity, and other risk factors can contribute to cardiac disease at any stage of life. A number of lifestyle factors, including a poor diet, inactivity, smoking, high blood pressure, diabetes, obesity, and stress, have an impact on cardiac health.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Genetic predisposition 52

Dr. Paddy Barrett

JANUARY 24, 2025

In the early 1970’s a group of 106 severely obese patients were put on a diet that resulted in an average weight loss of 63 Kg (139 lbs) over about one year 2. Weight loss was achieved through lifestyle modifications in nutrition, exercise, and psychology. They exercised daily. But Let Me Tell You A Story. Diabetologia.

Diet 52

Diet Obesity Diabetes Cholesterol 52

AMS Cardiology

SEPTEMBER 30, 2024

Heart disease prevention : By identifying risk factors for heart disease such as smoking, unhealthy diet and lack of exercise you can take steps to modify your lifestyle and reduce your risk. Exercise regularly : Aim for at least 30 minutes of moderate-intensity exercise most days.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Risk Factors 52

ADN Center of Excellence

SEPTEMBER 2, 2024

Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. Risk Factor Management: Controlling risk factors such as hypertension, diabetes, obesity, and sleep apnea is essential in managing AFib.

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Physiologically Speaking

APRIL 26, 2024

Even those of us who exercise for 1–2 hours per day still spend a large part of our day engaging in sedentary behavior (which, by the way, exercise doesn’t make us immune to). That’s better, but this behavioral category is missing the benefits of highly structured exercise.

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Blood Pressure Physiology Exercise Diet 52