Remove Exercise Remove Heart Failure Remove Obesity
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Metabolic Accelerator for Obesity-Related HFpEF

JAMA Cardiology

This randomized clinical trial evaluates if HU6, a controlled metabolic accelerator, reduces body weight, improves body composition, and increases exercise capacity in patients with obesity-related heart failure with preserved ejection fraction (HFpEF).

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Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Circulation: Heart Failure

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. BACKGROUND:Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. mL/kg per min lower peak VO2(β, −2.35±0.19;P<0.001).

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Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP?HF II trial

European Journal of Heart Failure

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Echocardiography demonstrated increased CO with obesity, but not estimated right atrial (RA) pressure or E/e′. Overall, 60.9%

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How High Blood Pressure Affects Your Heart and What You Can Do About It

MIBHS

Over time, this added workload causes the heart muscle to thicken, particularly in the left ventricle. This condition, known as left ventricular hypertrophy, can lead to heart failure if untreated. Heart Failure : Over time, the extra strain on your heart can lead to its weakening and eventual failure.

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Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting

Circulation

Optimal NT-proBNP cut points for HFpEF rule out (optimizing sensitivity) and rule in (optimizing specificity) were derived and tested, stratified by obesity and atrial fibrillation. In our study, NT-proBNP provided little value in those with AF and dyspnea because the presence of AF is by itself a robust biomarker of HFpEF.

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PO-04-064 INVASIVE HAEMODYNAMIC ASSESSMENT SHOWS THE OBESITY-HFPEF PHENOTYPE IS COMMON AMONGST PATIENTS WITH SYMPTOMATIC AF

HeartRhythm

The obesity-HFpEF phenotype is a unique form of heart failure associated with elevated LA and RA pressures, cardiac remodelling and poor exercise capacity. The influence of this HFpEF phenotype amongst patients with AF is unknown.

Obesity 40
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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two American Heart Association ( AHA ) presidential advisories published June 4 in the AHA journal Circulation. "The