Remove Exercise Remove Heart Failure Remove Obesity
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Metabolic Accelerator for Obesity-Related HFpEF

JAMA Cardiology

This randomized clinical trial evaluates if HU6, a controlled metabolic accelerator, reduces body weight, improves body composition, and increases exercise capacity in patients with obesity-related heart failure with preserved ejection fraction (HFpEF).

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Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Circulation: Heart Failure

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. BACKGROUND:Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. mL/kg per min lower peak VO2(β, −2.35±0.19;P<0.001).

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Alcohol and Heart Health: Understanding the Impact of Drinking on Your Heart

MIBHS

Studies show that repeated binge drinking can contribute to spikes in blood pressure, increasing the likelihood of stroke, heart attack, and heart failure. Heart Muscle Damage and Heart Failure The impact of drinking alcohol on the heart muscle is another critical area of concern.

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Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP?HF II trial

European Journal of Heart Failure

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Echocardiography demonstrated increased CO with obesity, but not estimated right atrial (RA) pressure or E/e′. Overall, 60.9%

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Effects of Tirzepatide on the Clinical Trajectory of Patients with Heart Failure, a Preserved Ejection Fraction, and Obesity

Circulation

Background: Patients with heart failure, a preserved ejection fraction (HFpEF), and obesity have significant disability and suffer frequent exacerbations of heart failure. 6MWD 302.881.7meters, and 53%(n=388) had a worsening heart failure event in the prior 12 months. Circulation, Ahead of Print.

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How High Blood Pressure Affects Your Heart and What You Can Do About It

MIBHS

Over time, this added workload causes the heart muscle to thicken, particularly in the left ventricle. This condition, known as left ventricular hypertrophy, can lead to heart failure if untreated. Heart Failure : Over time, the extra strain on your heart can lead to its weakening and eventual failure.

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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

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