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Case Report: Thrombus aspiration and in situ thrombolysis via a Guidezilla guide extension catheter in a patient with high-risk pulmonary embolism

Frontiers in Cardiovascular Medicine

In this case report, we demonstrated that thrombus aspiration and in situ thrombolysis through the Guidezilla GEC are applicable to patients with PE in whom systemic thrombolysis is contraindicated, resulting in successful reperfusion and positive clinical outcomes.

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Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT PE)

Circulation: Cardiovascular Interventions

BACKGROUND:Prior clinical trials have demonstrated the efficacy of ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk pulmonary embolism (PE) using reduced thrombolytic doses and shorter infusion durations. Circulation: Cardiovascular Interventions, Ahead of Print.

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Large-Bore Mechanical Thrombectomy or Catheter-Directed Thrombolysis For Management of Intermediate-High–Risk Pulmonary Embolism

American College of Cardiology

Acute pulmonary embolism (PE) remains a diagnostic and therapeutic challenge, with an estimated 60,000-100,000 deaths each year in the United States.

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Clot-in-transit and pulmonary embolism: an urgent call for awareness and action

Heart BMJ

Patients with acute pulmonary embolism (PE) have a wide spectrum of clinical presentations, from incidental findings to sudden cardiac death. Here, we propose an algorithm where the role of the Pulmonary Embolism Response Team (PERT) is reinforced. In this review, the challenges related to the identification of a CiT are highlighted.

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Large-Bore Mechanical Thrombectomy vs. Catheter-Directed Thrombolysis for Treatment of Intermediate-Risk Pulmonary Embolism

American College of Cardiology

The goal of the trial was to compare the efficacy and safety of large-bore mechanical thrombectomy (LBMT) with catheter-directed thrombolysis (CDT) in the treatment of intermediate-high risk pulmonary embolism (PE).

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Large-bore mechanical thrombectomy yields better outcomes for intermediate-risk pulmonary embolism

Medical Xpress - Cardiology

Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) show that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause (..)

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Simple and secure thrombectomy without circulatory arrest for acute pulmonary embolism

Journal of Cardiothoracic Surgery

Surgical pulmonary artery thrombectomy is a well-established emergency treatment for massive pulmonary embolism (PE) in which fibrinolysis or thrombolysis are not effective. However, surgery for massive PE tha.