Embolism, Outcomes and Thrombolysis - Cardiovascular Update

Case Report: Thrombus aspiration and in situ thrombolysis via a Guidezilla guide extension catheter in a patient with high-risk pulmonary embolism

Frontiers in Cardiovascular Medicine

MARCH 27, 2024

In this case report, we demonstrated that thrombus aspiration and in situ thrombolysis through the Guidezilla GEC are applicable to patients with PE in whom systemic thrombolysis is contraindicated, resulting in successful reperfusion and positive clinical outcomes.

Thrombolysis

Thrombolysis Embolism Pulmonary Anatomy

Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT PE)

Circulation: Cardiovascular Interventions

JANUARY 24, 2024

BACKGROUND:Prior clinical trials have demonstrated the efficacy of ultrasound-facilitated catheter-directed thrombolysis (USCDT) for the treatment of acute intermediate-risk pulmonary embolism (PE) using reduced thrombolytic doses and shorter infusion durations.

Embolism

Embolism Thrombolysis Ultrasound Pulmonary

Abstract 236: Effects of intravenous thrombolysis on thrombectomy outcomes: a systematic review and meta?analysis

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear. ResultsWe included four randomized controlled trials with 1176 patients.

Thrombolysis

Thrombolysis Outcomes Embolism Stents

Abstract WP199: Outcomes Following Posterior Cerebral Artery Thrombolysis vs Medical Management in those with Atrial Fibrillation

Stroke Journal

FEBRUARY 1, 2024

Background:The benefits of endovascular thrombectomy (EVT) for posterior cerebral artery (PCA) occlusion remain controversial, but intravenous thrombolysis (IVT) has proven benefit across nearly all ischemic stroke types.

Atrial Fibrillation

Atrial Fibrillation Thrombolysis Outcomes Embolism

Clinical Outcomes and Predictors of Advanced Therapy for the Management of Right Heart Thrombus

Circulation: Cardiovascular Interventions

FEBRUARY 27, 2024

Background:The role of advanced therapies (systemic thrombolysis, catheter-based treatment, and surgical thrombectomy) for the management of right heart thrombus is poorly defined. 0.99]) and concurrent pulmonary embolism (odds ratio, 5.36 [95% CI, 2.48–12.1]) Circulation: Cardiovascular Interventions, Ahead of Print.

Outcomes

Outcomes Thrombolysis Embolism Pulmonary

Abstract TP195: Impact of Intracranial Atherosclerotic Disease on Thrombectomy Outcomes in Acute Cerebral Infarction With Large Vessel Occlusion

Stroke Journal

FEBRUARY 1, 2024

Previous studies have noted that ICAD-related LVOs, compared to embolic occlusions, have longer procedural times and lower successful reperfusion rates. However, clinical outcomes remain similar. Patient outcomes at 3 months were assessed using modified Rankin Scale (mRS) scores, defining devastating outcomes as mRS 5-6.

Outcomes

Outcomes Embolism Atrial Fibrillation Thrombolysis

Abstract 97: Acute Ischemic Stroke Despite Anticoagulant Use: The Neuro-AFib Study

Stroke Journal

FEBRUARY 1, 2024

Chronic embolic (non-lacunar) infarcts on imaging were more common among AIS-despite-AC (34.5% The pattern of the acute infarcts (numbers, embolic features) was not different. Intravenous thrombolysis was used much less commonly for AIS-despite-AC (10.5% Patients who had AIS-despite-AC were younger (76.8+11 11 vs 77.8+12,

AFIB

AFIB Stroke Strokes Embolism

Abstract TP187: Comparison of Balloon Guide Catheter versus Non-Balloon Guide Catheter for Mechanical Thrombectomy in Distal Medium Vessel Occlusion

Stroke Journal

FEBRUARY 1, 2024

This study aimed to compare the outcomes of BGC vs non-BGC in DMVO thrombectomy.Methods:This retrospective study focused on DMVO cases defined as occlusions in M2-M4 middle cerebral artery, anterior cerebral artery, and posterior cerebral artery. The BGC group also had a lower FPE rate (17.4% vs. 30.7%, p = 0.03) in the Solumbra subgroup.

Embolism

Embolism Stents Stent Thrombolysis

Can we assess RV Function from JVP?

Dr. S. Venkatesan MD

JUNE 17, 2024

The usefulness of JVP in a cardiac emergency like acute pulmonary embolism may appear superfluous. But, the fact of the matter is, a persistently raised JVP with good waveform, without systemic hypotension, may not portend a bad outcome. Please go to the full-screen view and freeze the video to read the text. Here, is a real challenge.

Tricuspid

Tricuspid Thrombolysis Embolism Pulmonary

Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke

Stroke Journal

JANUARY 30, 2024

However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier.

Circulation

Circulation Stroke Strokes Embolism

Women and Black Patients Less Likely to Receive Catheter-based Treatment for Pulmonary Embolism According to REAL-PE Analysis Presented at SCAI 2024

DAIC

MAY 7, 2024

Women and black patients were less frequently treated with minimally invasive therapy compared to men or non-Black patients, according to new data from the REAL-PE analysis which investigated catheter-based pulmonary embolism (PE) treatment. A snapshot summary of the outcomes, as presented in a written statement issued by SCAI, follows.

Embolism

Embolism Pulmonary Blood Clot Interventional Cardiology

Initial Reperfusion T-waves, Followed by Pseudonormalization. Diagnosis?

Dr. Smith's ECG Blog

MARCH 11, 2016

Both of these are very suggestive of " No-Reflow ," or poor microvascular reperfusion due to downstream embolization of microscopic platelet-fibrin aggregates. Patients who received CPR or experienced reinfarction or very small infarcts due to thrombolysis also displayed Type II T-wave evolution. Methods: Vermeer et al.

Myocardial Infarction

Myocardial Infarction Pericarditis Angina STEMI

International Stroke Conference 2024 to Present High-Profile Late-Breaking Science

DAIC

JANUARY 22, 2024

Best Medical Therapy in Acute Ischemic Stroke due to Large VEssel OcclusioN Trial in the Extended Time Window: Raul Nogueira, University of Pittsburgh, Pittsburgh, PA MOST Multi-Arm Optimization of Stroke Thrombolysis Trial: Opeolu Adeoye, Washington University, Saint Louis, MO Thurs.,

Stroke

Stroke Strokes Hospital Thrombolysis

Abstract 047: Solumbra ‘PINCHING’ technique for medium vessel occlusions (MeVOs): A Single Center Experience

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Besides various demographic parameters, we collected final recanalization rates with first pass effect [using modified Thrombolysis in Cerebral Infarction (TICI) score]. All the intra‐procedural complications (haemorrhage, vasospasm) were analysed. years, mean NIHSS 9.1).

Stents

Stents Stent Thrombolysis Embolism

Case Report: Thrombus aspiration and in situ thrombolysis via a Guidezilla guide extension catheter in a patient with high-risk pulmonary embolism

Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT PE)

Abstract 236: Effects of intravenous thrombolysis on thrombectomy outcomes: a systematic review and meta?analysis

Abstract WP199: Outcomes Following Posterior Cerebral Artery Thrombolysis vs Medical Management in those with Atrial Fibrillation

Clinical Outcomes and Predictors of Advanced Therapy for the Management of Right Heart Thrombus

Abstract TP195: Impact of Intracranial Atherosclerotic Disease on Thrombectomy Outcomes in Acute Cerebral Infarction With Large Vessel Occlusion

Abstract 97: Acute Ischemic Stroke Despite Anticoagulant Use: The Neuro-AFib Study

Abstract TP187: Comparison of Balloon Guide Catheter versus Non-Balloon Guide Catheter for Mechanical Thrombectomy in Distal Medium Vessel Occlusion

Can we assess RV Function from JVP?

Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke

Women and Black Patients Less Likely to Receive Catheter-based Treatment for Pulmonary Embolism According to REAL-PE Analysis Presented at SCAI 2024

Initial Reperfusion T-waves, Followed by Pseudonormalization. Diagnosis?

International Stroke Conference 2024 to Present High-Profile Late-Breaking Science

Abstract 047: Solumbra ‘PINCHING’ technique for medium vessel occlusions (MeVOs): A Single Center Experience

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