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Fully published results from Athos Therapeutics AZALEA-TIMI 71 trial for its novel Factor XI inhibitor abelacimab, confirming the drugs lower bleeding risks, but leaving researchers uncertain about its ability to prevent stroke in AFib patients. vs. 0.4%) and 4X ischemic stroke rates (csHR = 4.06). year follow-up. per 100 person-year.
Massive pulmonary embolism (MPE) carries significant 30-day mortality and is characterized by acute right ventricular failure, hypotension, and hypoxia, leading to cardiovascular collapse and cardiac arrest. Considerable heterogeneity in studies is a significant weakness of the available literature.
Addressing the serious issue of delayed and missed findings in diagnostic imaging, CINA-iPE is an AI-powered tool that detects incidental pulmonary embolism during routine CT scans. This is particularly relevant in the cancer patient population, where pulmonary embolism is a significant cause of mortality.
Stroke, Volume 55, Issue Suppl_1 , Page A42-A42, February 1, 2024. Introduction:A new Plaque-RADS classification (I-IV) is proposed to categorize the degree of carotid plaque instability and risk of embolic ischemic stroke. Carotid total plaque thickness and ulceration were scored by a neuroradiologist blinded to stroke side.
Stroke, Volume 56, Issue Suppl_1 , Page ATP324-ATP324, February 1, 2025. Background and Purpose:Antiphospholipid antibody syndrome (APS) is a rare cause of cerebral infarction, but the effect of antiphospholipid antibodies (aPL) on the acute phase of ischemic stroke in each stroke subtypes is still unclear, especially in the elderly patients.
Introduction:Atrial myxomas are cardiac tumors that can cause arterio-occlusive diseases due to embolization of myxomatous fragments. Herein, we present a case of recurrent left atrial myxoma with hemorrhagic, cerebral embolization.Case Report:A 34-year-old male presented with acute onset numbness and tingling of the left arm.
Stroke, Volume 55, Issue 1 , Page 214-225, January 1, 2024. Nonvalvular atrial fibrillation is a common rhythm disorder of middle-aged to older adults that can cause ischemic strokes and systemic embolism.
Other select data from research studies unveiled last week at the American Heart Association ’s International Stroke Conference (ISC) underscore and reinforce the pivotal role of the RapidAI platform in advancing stroke care. Improved Stroke Outcomes Following Implementation of RapidAI Platform at Ascension-Illinois, by Malisch et.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. The Woven EndoBridge (WEB) is an ellipsoid embolization device designed to provide intrasaccular flow disruption along the aneurysm neck, which has been proven to be an effective method in treating a wide spectrum of wide‐necked bifurcation aneurysms.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Cerebral AVMs may manifest with new‐onset seizures or intraparenchymal (IPH) or subarachnoid hemorrhages (SAH). Cerebral AVMs may manifest with new‐onset seizures or intraparenchymal (IPH) or subarachnoid hemorrhages (SAH).
BackgroundPrevious studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. Little evidence of associations with the other stroke subtypes was found. Journal of the American Heart Association, Ahead of Print.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Rarely, thrombus formation within an aneurysm can lead to symptoms via distal embolization and infarction. Brain and orbits MRI with contrast showed no acute abnormalities, including no evidence of infarction or intracranial hemorrhage.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. 3 The third‐generation iteration of the Pipeline Embolization Device (PED) incorporates Shield technology, a phosphorylcholine coating designed to reduce thrombogenicity via mimicry of native cell membranes.4
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPosterior circulation strokes account for 20% of ischemic strokes (1). Optimal management for posterior circulation strokes has been studied less than for anterior circulation strokes (2). hours prior to arrival.
Stroke, Volume 56, Issue Suppl_1 , Page ATP13-ATP13, February 1, 2025. Background:Atrial fibrillation (AF) patients carry a high risk of stroke, and treatment related bleeding complications. 0.91), P<0.01), stroke by 19% (OR, 0.81(95%CI: 0.97), P=0.02), and hemorrhagicstroke by 57% (OR, 0.43(95%CI:
The efficacy outcome was the composite of stroke and systemic embolism. Safety outcomes included major bleeding, any clinically relevant bleeding, and intracranial hemorrhage. Stroke and systemic embolism risks did not differ significantly among DOACs. Unique identifier: CRD42022329557.
MRI Brain demonstrated Left MCA acute/subacute infarct, MCA/PCA watershed, and no hemorrhagic transformation. In general, the longer an AFib episode the more increased risk of stroke. Given infarct pattern on imaging, and obvious Advanced IAB on P-wave morphology, this is likely embolic PAF." Here is the admission ECG.
Stroke, Volume 55, Issue Suppl_1 , Page AWMP87-AWMP87, February 1, 2024. Time from puncture to recanalization was 68 and 42 minutes, and symptomatic intracranial hemorrhage was significantly different between 1.4% and 0%, recurrent stroke 6.4% and 0%, recurrent stroke 6.4% and 0.05%, respectively. Reocclusion was 3.1%
Known complications associated with cryoablation include tamponade, phrenic nerve injury, stroke, pulmonary embolism, pulmonary vein stenosis, and atrioesophageal fistulas. Cryoablation for atrial fibrillation is a widely used technique for pulmonary vein isolation.
Stroke, Volume 55, Issue Suppl_1 , Page A66-A66, February 1, 2024. Introduction:Clinical practice guidelines recommend initiation of anticoagulation within 2 weeks after stroke due to atrial fibrillation (AF). Patients were randomized into one of 4 Arms: Day 3-4 from stroke onset, Day 6, Day 10, or Day 14. non-white, and 16.5%
Stroke, Volume 55, Issue Suppl_1 , Page AWP23-AWP23, February 1, 2024. Introduction:Hemorrhagic transformation (HT) following acute ischemic stroke (AIS) is a common consideration especially when therapeutic anticoagulation is indicated in cases such as left ventricular or left atrial appendage thrombi.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Both anticoagulants can be used intraoperatively and postoperatively for DVT prophylaxis in patients undergoing subarachnoid hemorrhage (SAH) treatment. SAH severity was determined using the National Institute of Health Stroke Scale as a template.
The primary outcomes were ischemic stroke, systemic embolic events, and hospitalization for major bleeding. The secondary outcomes were intracranial hemorrhage, hospitalization for gastrointestinal bleeding, all‐cause mortality, and a composite outcome. The median follow‐up duration was 2.4 1.06];P=0.11).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionOsler‐Weber‐Rendu disease, also known as hereditary hemorrhagic telangiectasia (HTT), is a developmental vascular disease characterized by multiple arteriovenous malformations (AVMs) due to genetic defects in endothelial angiogenesis pathways.
Stroke, Volume 55, Issue Suppl_1 , Page AWP110-AWP110, February 1, 2024. Background:Antiplatelet administration within 48 hours of acute stroke presentation is standardized as it reduces mortality and recurrent ischemic stroke rate. Gender disparities have been noted in acute stroke care, including IV tPA and thrombectomy.
with 95% CI [1.59, 2.13], p <0.01), a 32% increase in the risk of intracranial hemorrhage (HR: 1.32 However, the impact of anemia did not significantly affect the risk of stroke, transient ischemic stroke (TIA), or systemic embolism (HR: 1.07 with 95% CI [1.46, 2.51], p <0.01). with 95% CI [0.93, 1.22], p =0.36).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionHere, we describe a patient in whom ischemic stroke was caused by compression of the Internal Carotid Artery (ICA) by a Pseudoaneurysm (PSA) of the External Carotid Artery (ECA) after Gun Shot injury.
BackgroundNonvitamin K oral anticoagulants prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Journal of the American Heart Association, Ahead of Print. Our analysis included 22 568 patients with nonvalvular atrial fibrillation (aged 75.7 years; 51.2%
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Cases of unruptured intracranial aneurysms (UIA) are estimated to affect roughly 3% of the general population and aneurysmal subarachnoid hemorrhage (aSAH) have an incidence of 8 to 9 people per 100,000.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionLoss of autoregulation after endovascular therapy (EVT) for large‐artery acute ischemic stroke (AIS) is well documented. [1] 2] This pattern indicates intact vasomotor reactivity to fluctuating O2 and CO2 levels during episodes of apnea.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionSubarachnoid Hemorrhage (SAH) resulting from the spontaneous rupture of an aneurysm is a rare and highly debilitating condition.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. They usually present as subarachnoid hemorrhage, or parenquimatous hemorrhage as in our patient. CT: SAH and parenquimatous left frontal basal hemorrhage of 2x3.4cm. Male, 46 years old, electric worker, right‐handed.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionDual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using Pipeline embolization device (PED). A p‐value <0.05
Stroke, Volume 55, Issue Suppl_1 , Page A134-A134, February 1, 2024. In severe OHSS, increases in capillary permeability can result in hemoconcentration and hypercoagulability leading to thrombotic events, including stroke and cerebral venous thrombosis. There were 1,955 hospitalizations for OHSS in NIS.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. Statistical analysis was performed to identify predictors of inadequate occlusion.ResultsA total of 51 patients underwent endovascular embolization using the WEB device with a mean follow‐up of 14.9 There were no hemorrhagic complications.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe Pipeline Embolization Device (PED) is commonly used for intracranial aneurysm treatment. While its effectiveness for certain types of aneurysms is well‐established, its efficacy for saccular aneurysms remains debatable.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear.
Stroke, Volume 55, Issue Suppl_1 , Page AWP221-AWP221, February 1, 2024. Outcomes have improved over time with advances in endovascular embolization. The pediatric-cured group demonstrated lower risk of intraprocedural or postprocedural hemorrhagic complications (p=0.03). in untreated patients.
Notice also the very small LV cavity size at both diastole and systole (poor LV filling with good contractility) and apparent low stroke volume. The RV was small and IVC empty, making pulmonary embolism extremely unlikely. This is very good evidence that the ST elevation is not due to STEMI. So there is poor LV filling.
Stroke, Volume 56, Issue Suppl_1 , Page ATP244-ATP244, February 1, 2025. Introduction:Although older patients with subarachnoid hemorrhage (SAH) are often preferentially treated with coiling, in practice, there are insufficient data to support a clear benefit of coiling in this population.
Stroke, Ahead of Print. BACKGROUND:A modified computed tomography angiography (CTA)based Carotid Plaque Reporting and Data System (Plaque-RADS) classification was applied to a cohort of patients with embolicstroke of undetermined source to test whether high-risk Plaque-RADS subtypes are more prevalent on the ipsilateral side of stroke.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP108-ATMP108, February 1, 2025. Patients with traumatic brain injury, intracranial hemorrhage, recent neurosurgical procedures, or ischemic stroke at admission were excluded. The patients with acute ischemic stroke were older (p<0.01). 0.87], p<0.01).
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe use of detachable coils for endovascular embolization of cerebral aneurysms has become a safe and effective alternative to direct surgical clipping in patients with ruptured aneurysmal subarachnoid hemorrhage.
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