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Findings from the first international randomized controlled trial to compare patient outcomes following treatment with large-bore mechanical thrombectomy (LBMT) versus catheter-directed thrombolysis (CDT) for intermediate-risk pulmonary embolism (PE) show that LBMT is superior with respect to the hierarchically-tested aggregated outcome of all-cause (..)
Massive pulmonary embolism (MPE) carries significant 30-day mortality and is characterized by acute right ventricular failure, hypotension, and hypoxia, leading to cardiovascular collapse and cardiac arrest. Considerable heterogeneity in studies is a significant weakness of the available literature.
Introduction:Although older patients with subarachnoid hemorrhage (SAH) are often preferentially treated with coiling, in practice, there are insufficient data to support a clear benefit of coiling in this population. Other endpoints were an unfavorable outcome in the GOS, mortality and a favorable outcome in the mRS separately.
Current guidelines recommend direct-acting oral anticoagulants (DOACs) for AF because they reduce ischemic stroke with a lower risk of brain hemorrhage. Unfortunately, DOACs often cause gastrointestinal bleeding, which prompted the development of new stroke-prevention methods like Factor XI inhibition. per 100 person-years vs. 0.83).
IntroductionThe use of detachable coils for endovascular embolization of cerebral aneurysms has become a safe and effective alternative to direct surgical clipping in patients with ruptured aneurysmal subarachnoid hemorrhage. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.
The purpose of this study was to compare the outcomes of EVT for ICAD with those of cardiogenic cerebral embolism (CE) based on real-world data from a multicenter, prospective registry study (K-NET registry) involving 40 centers in Japan.Methods:The K-NET study enrolled 3187 EVTs in 2018-2021, of which 358 (11%) were ICAD and 1870 (59%) were CE.
Both anticoagulants can be used intraoperatively and postoperatively for DVT prophylaxis in patients undergoing subarachnoid hemorrhage (SAH) treatment. Patients from both groups were assessed for baseline clinical characteristics, comorbidities, interventions, complications, and outcomes.
Patients with a history of prior hemorrhagic stroke were excluded from this analysis. Multivariable Cox proportional hazards models and Fine-Gray sub-distribution hazards models were used to adjust for confounding factors.
This has been associated with poor clinical outcomes. We aim to investigate the impact of anemia on clinical outcomes in patients with AF on oral anticoagulation. with 95% CI [1.59, 2.13], p <0.01), a 32% increase in the risk of intracranial hemorrhage (HR: 1.32 with 95% CI [1.46, 2.51], p <0.01).
Cerebral AVMs may manifest with new‐onset seizures or intraparenchymal (IPH) or subarachnoid hemorrhages (SAH). The inflow aneurysms were accessed and embolized with coils using a second microcatheter prior to AVM embolization. Embolization of three posterior feeding pedicles was subsequently performed utilizing dilute NBCA.
The primary efficacy and safety outcomes were stroke or systemic embolic events (stroke/SEE) and major bleeding, respectively; secondary outcomes were ischemic stroke/SEE, intracranial hemorrhage, death, and the net clinical outcome (stroke/SEE, major bleeding, or death). interquartile range, 25.2–32.2)
3 The third‐generation iteration of the Pipeline Embolization Device (PED) incorporates Shield technology, a phosphorylcholine coating designed to reduce thrombogenicity via mimicry of native cell membranes.4 One patient had a new intraparenchymal hemorrhage, but no appreciable deficit.
mismatch volume of ≥15 mL, and ischemic core volume TIMELESS is the first study to show that an intravenous thrombolytic can be given up to 24 hours after LKW without an increase in brain hemorrhage. Improved Stroke Outcomes Following Implementation of RapidAI Platform at Ascension-Illinois, by Malisch et.
The primary outcomes were ischemic stroke, systemic embolic events, and hospitalization for major bleeding. The secondary outcomes were intracranial hemorrhage, hospitalization for gastrointestinal bleeding, all‐cause mortality, and a composite outcome. The median follow‐up duration was 2.4 1.06];P=0.11).
We searched the PubMed, EMBASE, and Cochrane databases for randomized controlled trials that compared thromboembolic or bleeding outcomes between a direct oral anticoagulant (DOAC) and a vitamin K antagonist (VKA) and reported outcomes for patients aged ≥75 years with atrial fibrillation. prospero/.
IntroductionSubarachnoid Hemorrhage (SAH) resulting from the spontaneous rupture of an aneurysm is a rare and highly debilitating condition. The AKI and non‐AKI groups were assessed for baseline clinical characteristics, interventions, complications, and outcomes.
However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear. Moreover, our results indicate that administration of IVT before MT may improve certain outcomes based on the used first‐line MT technique. ResultsWe included four randomized controlled trials with 1176 patients.
The receiving staff suspects pulmonary embolism due to S1Q3T3 on the ECG and administers TPA. The patient did have massive pulmonary emboli, but he also had profound intraventricular and subarachnoid hemorrhages. The patient was ultimately discharged with a poor neurologic outcome. On ED arrival ROSC is achieved.
Cases of unruptured intracranial aneurysms (UIA) are estimated to affect roughly 3% of the general population and aneurysmal subarachnoid hemorrhage (aSAH) have an incidence of 8 to 9 people per 100,000. The subjects were followed for 6 months (‐4 months/+6 months).
Introduction:Brain injury is the main cause of death and disability post-cardiac arrest, and hypoxic-ischemic brain injury (HIBI) severity is associated with poor outcomes. Patients with traumatic brain injury, intracranial hemorrhage, recent neurosurgical procedures, or ischemic stroke at admission were excluded.
IntroductionThe Pipeline Embolization Device (PED) is commonly used for intracranial aneurysm treatment. This review and meta‐analysis aimed to assess the long‐term outcomes of PED treatment for unruptured intracranial aneurysms (UIA).MethodsA Secondary outcomes included long‐term complications.
Embolization is now a well‐established endovascular technique to treat traumatic hemorrhagic injuries(4). On arrival at the hospital, the patient was hemodynamically stable with no ongoing hemorrhage or respiratory distress. Retrograde filling of the internal maxillary artery was noted.
We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes.Methods and ResultsTwo‐sample Mendelian randomization analyses were conducted. Little evidence of associations with the other stroke subtypes was found.
IntroductionTo provide our single‐institution experience and outcome data with the WEB device in 51 patients treated for ruptured and unruptured intracranial aneurysms.MethodsOcclusion rates in a cohort of 51 patients treated with WEB were collected at time of procedure and at last follow‐up between the years 2019 and 2021.
The primary outcome was an ischemic (stroke or systemic embolus) or hemorrhagic (ICH or major systemic hemorrhage) event observed within 30 days from the index stroke time of onset. No ischemic events were observed for Arm 1, and no hemorrhage events were observed for Arm 4. at the time of randomization.
However, hemorrhagic stroke (RR = 0.46; 95% CI [0.30, 0.69]; I2= 24%; p < 0.001), intracranial bleeding (0.82% vs 1.8% However, hemorrhagic stroke (RR = 0.46; 95% CI [0.30, 0.69]; I2= 24%; p < 0.001), intracranial bleeding (0.82% vs 1.8% The pooled results showed that cardiovascular death (4.9%
Specific aspects of IRF care driving better vascular outcomes need further evaluation. Patients <65 years had a similar pattern of associations as the combined data but among those aged 65 years, IRF discharge was only associated with lower mortality (vs SNF: 0.63, 0.48-0.81).Conclusions:Post-acute
Outcomes have improved over time with advances in endovascular embolization. Patients were stratified based on radiographic outcomes: cured before the age of 18 (“pediatric-cured group”), cured after the age of 18, or not cured. Long-term functional outcomes were assessed using the modified Rankin Scale (mRS).
Our primary study outcome was any stroke or major thrombotic event identified within 60 days of OHSS diagnosis in HCUP or during the index admission for OHSS in NIS. The low rate of outcome events after OHSS seen in each of our population-level analyses increases the reliability of these study results.
Eventually, the PSA of the Internal maxillary artery (IMAX) was embolized, resulting in resolution of the patient's symptoms.MethodsCase ReportResultsA 75‐year‐old male with a history of atrial fibrillation on Eliquis presented to the emergency department after sustaining a gunshot wound to the left face.
Objective:The role of statins in the management of intracerebral hemorrhage (ICH) remains controversial. Stroke, Volume 56, Issue Suppl_1 , Page ATP328-ATP328, February 1, 2025. Model fit was assessed using the Hosmer-Lemeshow test.Results:Among 142 eligible pre-ICH statin users (median age [IQR]: 77.5 [72-86] 72-86] years; 57.0%
1] This might result in worse outcomes, despite successful recanalization, from hyper‐ or hypoperfusion with a risk for hemorrhagic conversion or larger stroke volume, respectively. An Embolic etiology was suspected and a 20‐minuteTCD was done for spontaneous emboli detection on bilateral middle cerebral arteries (MCA).
Secondary endpoints included good functional outcomes (mRS 0‐2) at Day 90, revascularization time, first line and first pass mTICI ≥2b, occurrence of procedure‐related SAEs, vasospasm involving the accessed vascular tree, embolization to new territories (ENTs), symptomatic intracerebral hemorrhage (sICH) within 24 hours and mortality at Day 90.MethodsSOFAST
Kown, Asan Medical Center, Seoul, Korea Golden Bridge II Effect of an Artificial Intelligence-Based Clinical Decision Support System on Stroke Care Quality and Outcomes in Patients With Acute Ischemic Stroke : A Cluster-Randomized Clinical Trial: Zixiao Li, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Friday, Feb.
Our study aimed to compare outcomes of patients diagnosed with CVT within 2 weeks of COVID infection compared to those without COVID-19.Methods:Adult All-cause mortality was the primary outcome. Stroke, Volume 55, Issue Suppl_1 , Page AWMP49-AWMP49, February 1, 2024. vs 13.6%; HR=1.51; 95% CI=1.04-2.20) 2.20) but not at three months.
The second most common treatment modality was endovascular embolization (36.9%). Eleven patients experienced intracranial hemorrhage as a complication of CPA; 10 of the 11 patients underwent decompressive craniectomy. These studies consisted of 41 case reports, 6 case series, and 1 retrospective cohort study.
Also consider non-hemorrhagic volume depletion, dehydration : orthostatic vitals may uncover this [see Mendu et al. (3)]. Cardiac Syncope ("True Syncope") Independent Predictors of Adverse Outcomes condensed from multiple studies 1. These premonitory symptoms were negative predictors of adverse outcomes in EGSYS.
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