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This underuse of anticoagulants for stroke prevention has been cited as one of the greatest public health issues facing cardiovascular patients 6. Many doctors are put in the unfortunate position of having to weigh the risk of stroke against the risk of bleeding for their patients with AFib, said Christian T.
Ruff, MD, MPH, senior investigator of TIMI Group, director GeneralCardiology, Brigham and Women's Hospital, and associate professor, Harvard Medical School. There is a need for safer anticoagulants that can prevent thrombotic events while minimizing excess bleeding, said Christian T.
In an earlier post on EmbolicStroke of Undetermined Source (ESUS) , I had mentioned about ARCADIA trial (AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke) which was testing whether there is role for apixaban compared to aspirin for prevention of recurrent stroke in ESUS. 2023.27188.
SAM causes LVOTO, increased ejection time and a decreased stroke volume, as well as mitral regurgitation due to poor coaptation of the leaflets. Mid cavity obstruction in HCM is associated with apical aneurysm, systemic embolism, and arrhythmias. Echocardiogram showing thickened interventricular septum and mitral regurgitation in HCM.
About a fifth of all ischemic strokes are attributed to embolization of ruptured atherosclerotic plaque from carotid arterial stenosis. But it has been difficult to predict which person with asymptomatic carotid artery stenosis is likely to progress to symptomatic carotid disease and stroke.
Ischemic stroke, systemic embolism, intracranial or fatal extracranial bleeding and death with recent evidence of bleeding were the secondary outcomes evaluated. It was a retrospective cohort study which included US Medicare benefiaries aged 65 years or more with atrial fibrillation and follow up period was one year.
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