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BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.
Abstract Introduction Atrial fibrillation and atrial flutter originating from the donor s heart is a commonly reported complication post heart transplant. Case A 47-year-old male presented with atrial tachycardia 6 months post heart transplant. This arrhythmia was successfully terminated with radiofrequency ablation.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. The transplant-free survival rates at 3, 5, and 8 years after CRT implantation were 85%, 79%, and 73%.CONCLUSIONS:In Although cardiac resynchronization therapy (CRT) is an established treatment option, the effect of CRT in this population is still not well defined.
Lethally irradiated mice were transplanted with hematopoietic-specific loss ofTet2, hematopoietic-specific loss ofTet2andNlrp3, or wild-type control and fed a Western diet, compounded with or without NLRP3 (NLR [NACHT, LRR {leucine rich repeat}] family pyrin domain containing protein 3) inhibitor, NP3-361, for 6 to 9 weeks.
Two cases were postbilateral orthotopic lung transplant, without appropriate femoral or jugular access due to recent ECMO cannulation and jugular central venous catheters. Abstract Introduction Transsubclavian venous implantation of the Aveir leadless cardiac pacemaker (LCP) has not been previously reported.
After excluding patients with congenital or rheumatic heart disease, heart transplant recipients, or those without baseline echocardiogram, a total of 130 patients were included in the analysis. Echocardiographic data were analyzed at baseline before ablation, and at early follow-up within 1-year postablation.
Cardiac transplantation, the only option for many patients, is severely restricted by the limited availability of donor hearts. The research is funded by a four-year, $7.8 Patients with heart failure often experience reduced mobility, quality of life and ability to work; the disease also represents a significant public health care burden.
The primary outcome was death from any cause, and the secondary outcome included a composite of death, heart transplantation, or ventricular assist device implantation. Long-term outcomes were assessed at the eight highest-enrolling sites. In the RAFT trial, 1798 patients were enrolled by February 2009.
Heart failure, heart transplantation and death by cardiac causes were more often seen in individuals with biventricular phenotype compared to isolated left or right ventricular phenotype.
The composite outcome of VT/VF recurrence, heart transplantation, or death occurred in 6/12 patients (50%) without dofetilide and 49/69 patients (71%) with dofetilide. Dofetilide had to be discontinued in 50/69 patients (72%) due to inefficacy or intolerance.
The primary endpoint was a composite of all-cause mortality, left ventricular assist device (LVAD)/heart transplantation, HF hospitalizations, worsening HF, and KCCQ score changes. RELIEVE-HF 7 ( NCT03499236 ) evaluated the efficacy and safety of the V-wave interatrial shunt system in patients with HF.
Hunter Mehaffey Distressed communities are associated with worse outcomes after coronary artery bypass surgery The Journal of Thoracic and Cardiovascular Surgery August 2019 Meghana Helder Regional and Temporal Trends in the Outcomes of Repairs for Acute Type A Aortic Dissections The Annals of Thoracic Surgery August 2019 Derrick Tam Surgical valve (..)
Hunter Mehaffey 1 Distressed communities are associated with worse outcomes after coronary artery bypass surgery The Journal of Thoracic and Cardiovascular Surgery August 2019 Meghana Helder 2 Regional and Temporal Trends in the Outcomes of Repairs for Acute Type A Aortic Dissections The Annals of Thoracic Surgery August 2019 Derrick Tam 2 Surgical (..)
In heart transplant patients with pacemakers, electrical parameters remained stable and within the device's operational safety margins, except for a decrease in P-wave amplitude that could be related to progressive graft fibrosis. ABSTRACT Background Approximately 10% of heart transplant (HT) recipients require a pacemaker (PM) implant.
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