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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

Frontiers in Cardiovascular Medicine

BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.

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Posttransplant atrial fibrillation: Evidence of early posttransplant recipient?to?donor atrioatrial connections

Journal of Cardiovascular Electrophysiology

Abstract Introduction Atrial fibrillation and atrial flutter originating from the donor s heart is a commonly reported complication post heart transplant. Case A 47-year-old male presented with atrial tachycardia 6 months post heart transplant. This arrhythmia was successfully terminated with radiofrequency ablation.

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Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. The transplant-free survival rates at 3, 5, and 8 years after CRT implantation were 85%, 79%, and 73%.CONCLUSIONS:In Although cardiac resynchronization therapy (CRT) is an established treatment option, the effect of CRT in this population is still not well defined.

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Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation

Circulation

Lethally irradiated mice were transplanted with hematopoietic-specific loss ofTet2, hematopoietic-specific loss ofTet2andNlrp3, or wild-type control and fed a Western diet, compounded with or without NLRP3 (NLR [NACHT, LRR {leucine rich repeat}] family pyrin domain containing protein 3) inhibitor, NP3-361, for 6 to 9 weeks.

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First?in?man report of transsubclavian venous implantation of the Aveir leadless cardiac pacing system

Journal of Cardiovascular Electrophysiology

Two cases were postbilateral orthotopic lung transplant, without appropriate femoral or jugular access due to recent ECMO cannulation and jugular central venous catheters. Abstract Introduction Transsubclavian venous implantation of the Aveir leadless cardiac pacemaker (LCP) has not been previously reported.

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Catheter ablation of typical atrial flutter improves cardiac chamber size and function

Journal of Cardiovascular Electrophysiology

After excluding patients with congenital or rheumatic heart disease, heart transplant recipients, or those without baseline echocardiogram, a total of 130 patients were included in the analysis. Echocardiographic data were analyzed at baseline before ablation, and at early follow-up within 1-year postablation.

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The Texas Heart Institute Collaborates on Multi-institutional DOD Grant to Develop Novel Left Ventricular Assist Device

DAIC

Cardiac transplantation, the only option for many patients, is severely restricted by the limited availability of donor hearts. The research is funded by a four-year, $7.8 Patients with heart failure often experience reduced mobility, quality of life and ability to work; the disease also represents a significant public health care burden.