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ABSTRACT Suddencardiacdeath (SCD) is a major public health challenge, resulting in significant loss of life each year. Effective prevention relies on identifying individuals at elevated risk; however, accurate prediction of SCD has proven difficult.
Abstract Brugada syndrome (BrS) is a cardiacelectrophysiological disease with unknown etiology, associated with suddencardiacdeath. Symptomatic patients are treated with implanted cardiac defibrillator, but no risk stratification strategy is effective in patients that are at low to medium arrhythmic risk.
Sustained MVT affects approximately 10% of such patients at 30 years after cardiac repair and is inextricably related to the burden of suddencardiacdeath (SCD).(1) Tetralogy of Fallot (TOF) represents the poster child for monomorphic ventricular tachycardia (MVT) in congenital heart disease.
Abstract The limited literature and increasing interest in studies on cardiacelectrophysiology, explicitly focusing on cardiac ion channelopathies and suddencardiacdeath in diverse populations, has prompted a comprehensive examination of existing research.
Diabetes mellitus (DM) confers an increased risk of suddencardiacdeath (SCD) independent of its associated cardiovascular comorbidities. Diabetes mellitus induces adverse structural, electrophysiological, and autonomic cardiac remodeling which can increase one’s risk of ventricular arrhythmias and SCD.
“I am grateful to my ACC colleagues for recognizing our work with this prestigious award,” said Chugh, associate director of the Smidt Heart Institute and the Pauline and Harold Price Chair in CardiacElectrophysiology Research at Cedars-Sinai. The credit goes to my mentees and colleagues over the years.
Patients with repaired tetralogy of Fallot are at risk of ventricular tachycardia (VT) and suddencardiacdeath. Historically, risk stratification electrophysiologic studies involved programmed ventricular stimulation with VT induction guiding implantable cardioverter-defibrillator (ICD) implantation or VT ablation.
Suddencardiacdeath (SCD) is one of the most important causes of mortality in the world. Myocardial infarction (MI) is a major risk factor for SCD associated with significant pro-arrhythmic structural and electrophysiological ventricular remodelling.
Contemporary antiarrhythmic treatment of Timothy syndrome 1 (TS1) is inadequate to prevent suddencardiacdeath. Using electroanatomic mapping (EAM) we discovered cardiac activation delay, which creates the milieu for functional reentrant ventricular arrhythmias.
Journal of Cardiovascular Electrophysiology, Volume 30, Issue 10, October 2019, Pages 1994–2001. Single- versus dual-chamber implantable cardioverter-defibrillator for primary prevention of suddencardiacdeath in the united states” J Am Heart Assoc. Hindricks G, Theuns DA, Bar-Lev D, et al. Margolis G, et al.
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Secondary outcomes included trends of suddencardiacdeath, appropriate/inappropriate shocks, and ICD-related complications.RESULTS:In total, 234 studies (N=92 500, 514 748 patient-years) met inclusion criteria. Mean age was 46.2 years and 37.49% were women.
Brugada syndrome is thought to account for about one fourth of suddencardiacdeaths in individuals with structurally normal heart. This is mainly to account for the individual variation in anatomical location of right ventricular outflow tract, the main location of electrophysiological abnormalities in Brugada syndrome.
ABSTRACT The first viable alternative to surgical implantation of an epicardial defibrillator system for secondary prevention of suddencardiacdeath (SCD) was a single chamber transvenous implantable cardioverter defibrillator (ICD).
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Commotio cordis, suddencardiacdeath (SCD) caused by relatively innocent impact to the chest, is one of the leading causes of SCD in sports.
ABSTRACT Introduction Substernal extravascular defibrillators (EV ICDs) have been shown to be effective and safe for patients at risk of suddencardiacdeath, however, there is little evidence around the safety of extracting chronic devices.
It is also published in Heart Rhythm , the official journal of the HRS, Journal of Arrhythmia , the official journal of the APHRS, and Journal of Interventional CardiacElectrophysiology , the official journal of the LAHRS. 7 Atrial fibrillation has a significant impact on people’s lives.
The Smidt Heart Institute recently received CAROL Act funding to study the connection between ventricular arrhythmias—abnormal heartbeats that start in the heart’s two lower chambers—and an elevated risk of suddencardiacdeath in patients with mitral valve disease.
Transcript of the video: Brugada Syndrome was described by Brugada brothers in 1992 as right bundle branch block pattern in anterior leads with ST segment elevation and syncope or suddencardiacdeath and it was later in 1998, that the genetic basis of the disease was identified, with mutations in sodium channel.
Experimentally, direct cardiac nerve stimulation of sympathetic nerve endings, as well as parasympathetic control of the atrioventricular node, provided the background to new detailed autonomic studies of the heart.
New HCM Guidelines Updated recommendations in the guideline reflect recent evidence about HCM treatment and management including new forms of pharmacologic management; participation in vigorous recreational activities and competitive sports; and risk stratification for suddencardiacdeath (SCD) with an emphasis on pediatric patients.
ABSTRACT Arrhythmogenic cardiomyopathy (ACM) is a genetically heterogeneous inherited cardiomyopathy with an estimated prevalence of 1:500010000 that predisposes patients to life-threatening ventricular arrhythmias (VA) and suddencardiacdeath (SCD).
Abstract Introduction Wearable cardioverter defibrillator (WCD) is utilized in patients with assumed but not yet confirmed risk for suddencardiacdeath (SCD). Many of these patients also present with atrial fibrillation (AF).
A subgroup of patients with MVP may experience ventricular arrhythmias and suddencardiacdeath (“arrhythmic mitral valve prolapse” [AMVP]) but how to stratify arrhythmic risk is still unclear. Abstract Introduction Mitral valve prolapse (MVP) is a common clinical condition in the general population.
Abstract Introduction Most patients with Brugada syndrome (BrS) are first diagnosed in their 40s, with suddencardiacdeath (SCD) often occurring in their 50s. Ventricular fibrillation (VF) may occur in some patients with BrS despite having been asymptomatic for a long period.
He said a screening test called cardiac-arrhythmic genome analysis is available in certain European centers. The role of the molecular autopsy in suddencardiacdeath in young individuals. Pacing and Clinical Electrophysiology, 35(7), e210–e213. Ref: Isbister, J.C., Semsarian, C. Reference 1. Circulation.
This discussion comes from this previous post: Hyperthermia and ST Elevation Discussion Brugada Type 1 ECG changes are associated with suddencardiacdeath (SCD) and the occurrence of ventricular dysrhythmias. She has not yet been seen by electrophysiology or had further genetic testing for Brugada syndrome. per year.
A case for pleomorphism Josephson elucidated the concept of pleomorphism during electrophysiological study of patients with recurrent, sustained ventricular tachycardia. Josephson’s Clinical CardiacElectrophysiology: Techniques and Interpretations (6th ed). Pleomorphic ventricular tachycardia and risk for suddencardiacdeath.
Abstract Introduction Despite advancements in implantable cardioverter-defibrillator (ICD) technology, suddencardiacdeath (SCD) remains a persistent public health concern.
The limb lead abnormalities appear to be part of the Brugada pattern, as described in this article: Inferior and Lateral Electrocardiographic RepolarizationAbnormalities in Brugada Syndrome Discussion Brugada Type 1 ECG changes are associated with suddencardiacdeath (SCD) and the occurrence of ventricular dysrhythmias.
channel function.ObjectiveTo better understand LQT2, we examined the electrophysiological differences related to the G53S variant, which is located within the PAS domain of KCNH2, using patient-specific human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs).MethodsWe
AF is associated with an increased risk of death as well as multiple adverse outcomes, including stroke, cognitive impairment or dementia, myocardial infarction, suddencardiacdeath, heart failure (HF), chronic kidney disease (CKD), and peripheral artery disease (PAD). million.
ABSTRACT Introduction Brugada syndrome (BS) is a genetic channelopathy characterized by an increased risk of suddencardiacdeath (SCD) in the absence of structural heart disease. Prognostic stratification is necessary to determine which patients are candidates for implantable cardioverter defibrillator (ICD).
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:Sudden cardiacdeath is the most common cause of death in childhood hypertrophic cardiomyopathy (HCM). Recently, 2 risk scores have been developed to estimate the 5-year risk of suddencardiacdeath.
A score including ECG pattern, early familial SCD antecedents, inducible electrophysiological study, presentation as syncope or as aborted SCD and SND had a predictive performance of 0.82. Twenty-one percent (18 of 88) had a family history of suddencardiacdeath and 26.4% (14 of 53) carried a pathogenic SCN5A mutation.
I found articles by Di Diego JM & Antzelevitch C ( J Wave Syndromes as a Cause of Malignant Cardiac Arrhythmias Pacing Clin Electrophysiol 41(7): 684-699, 2018 ) and by Ali et al ( Early Repolarization Syndrome: A Cause of SuddenCardiacDeath World J Cardiology 7:466-475, 2015 ) to be insightful.
ABSTRACT Background Mitral annular disjunction (MAD) carries an increased risk of complex ventricular arrhythmias, which can lead to suddencardiacdeath. Many of these patients undergo implantable cardioverter defibrillator (ICD) implantation, but their ICD outcomes are not known.
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