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Atrial Fibrillation (AF) and Heart Failure With Preserved Ejection Fraction (HFpEF): Advances and Challenges

Journal of Cardiovascular Electrophysiology

It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated in this review.

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Heart failure with preserved ejection fraction and atrial fibrillation: clinical management in the context of recent therapeutic advances in heart failure and electrophysiology

Frontiers in Cardiovascular Medicine

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have emerged as major age-related epidemics within cardiology.

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Modeling Heart Failure With Preserved Ejection Fraction Using Human Induced Pluripotent Stem Cell–Derived Cardiac Organoids

Circulation: Heart Failure

BACKGROUND:The therapeutic armamentarium for heart failure with preserved ejection fraction (HFpEF) remains notably constrained. Circulation: Heart Failure, Ahead of Print. A factor contributing to this problem could be the scarcity of in vitro models for HFpEF, which hinders progress in developing new therapeutic strategies.

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Basic Science of Cardiac Contractility Modulation Therapy: Molecular and Electrophysiological Mechanisms

HeartRhythm

In heart failure with reduced ejection fraction and heart failure with preserved ejection fraction, profound cellular and molecular changes have recently been documented in the failing myocardium.These changes include altered calcium handling and metabolic efficiency of the cardiac myocyte, reactivation of the fetal gene program, changes in the electrophysiological (..)

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Is sinus rhythm maintenance after repeat catheter ablation effective in patients with atrial fibrillation and heart failure with preserved ejection fraction?

Journal of Cardiovascular Electrophysiology

Abstract Background Heart failure (HF) with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are associated with high morbidity and mortality. Recently, sinus rhythm (SR) maintenance (SRM) after catheter ablation (CA) of AF (AFCA) in HFpEF has shown to reduce adverse events as compared to medical treatment.

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PO-07-197 ARRHYTHMIC RISK STRATIFICATION IN POST-MYOCARDIAL INFARCTION PATIENTS WITH PRESERVED EJECTION FRACTION: LONG-TERM OUTCOMES IN PRESERVE EF STUDY

HeartRhythm

The PRESERVE EF study proposed a two-step algorithm for risk stratification in post-myocardial infarction patients with mid-range and preserved left ventricular ejection fraction (LVEF). This report presents the 8-year follow-up findings of the trial.

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Atrial fibrillation and risk of adverse outcomes in heart failure with reduced, mildly reduced, and preserved ejection fraction: A systematic review and meta?analysis

Journal of Cardiovascular Electrophysiology

Contemporary classification of HF categorizes it into HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF). Abstract Introduction Heart failure (HF) and atrial fibrillation (AF) frequently co-exist.