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It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preservedejectionfraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated in this review.
BACKGROUND:The therapeutic armamentarium for heart failure with preservedejectionfraction (HFpEF) remains notably constrained. Circulation: Heart Failure, Ahead of Print. A factor contributing to this problem could be the scarcity of in vitro models for HFpEF, which hinders progress in developing new therapeutic strategies.
In heart failure with reduced ejectionfraction and heart failure with preservedejectionfraction, profound cellular and molecular changes have recently been documented in the failing myocardium.These changes include altered calcium handling and metabolic efficiency of the cardiac myocyte, reactivation of the fetal gene program, changes in the electrophysiological (..)
Abstract Background Heart failure (HF) with preservedejectionfraction (HFpEF) and atrial fibrillation (AF) are associated with high morbidity and mortality. Recently, sinus rhythm (SR) maintenance (SRM) after catheter ablation (CA) of AF (AFCA) in HFpEF has shown to reduce adverse events as compared to medical treatment.
Contemporary classification of HF categorizes it into HF with reduced ejectionfraction (HFrEF), HF with mildly reduced ejectionfraction (HFmrEF), and HF with preservedejectionfraction (HFpEF). Abstract Introduction Heart failure (HF) and atrial fibrillation (AF) frequently co-exist.
Impact of preceding systolic heart failure on risk of pacemaker-induced cardiomyopathy Abstract Background Pacemaker-induced cardiomyopathy is a well described phenomenon in patients with preservedejectionfraction at the time of permanent pacemaker implant.
Session 104) - What Is Really New in Electrophysiology That Will Change My Practice? The Guidelines Sessions at ACC.24 24: Joint American College of Cardiology/Journal of the American College of Cardiology Late-Breaking Clinical Trials (Session 402) Saturday, April 6 9:30 – 10:30 a.m.
Abstract Introduction Catheter ablation for atrial fibrillation (AF) reduces heart failure (HF) hospitalization in patients with HF with preservedejectionfraction (HFpEF). However, the long-term outcomes and subclinical HF after nonparoxysmal AF ablation in HFpEF patients have not been fully evaluated.
STEP-HFpEF DM 5 ( NCT04916470 ) explored the effects of semaglutide in obesity-related HF with preservedejectionfraction (HFpEF) and type 2 diabetes. The self-expanding valve was also superior with respect to bioprosthetic-valve dysfunction through 12 months.
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