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It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heartfailure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heartfailure physiology are intertwined and are integrated in this review.
It can be associated with reduced quality of life and complications such as heartfailure and stroke. Additional advantages include providing electrophysiology lab personnel with a lead-free working environment and avoiding radiation exposure for both patients and physicians.
Background Sacubitril/valsartan (SacVal) has been shown to improve the prognosis of heartfailure; however, whether SacVal reduces the occurrence of atrial fibrillation (AF) in heartfailure has not yet been elucidated.
Heartfailure (HF) is recognized as an epidemic in the contemporary world, impacting around 1%–2% of the adult population and affecting around 6 million Americans. Among the most serious manifestations associated with HF is arrhythmia due to the electrophysiological changes within the cardiomyocyte.
Heartfailure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have emerged as major age-related epidemics within cardiology. Indeed, these two conditions are commonly found in the same individual, so much so that AF has been used in proposed diagnostic criteria for HFpEF.
Slow VT below the detection rate of the ICD lead to worsening heartfailure and low stroke volume. Post conversion of VT the patient had low output cardiac failure and became unstable and hypoperfused. Cardiac output (CO) was being maintained by the tachycardia. After atrial rhythm/SR was restored the patient slowly improved.
Background The use of SGLT-2 inhibitors has revolutionized heartfailure therapy. In the presence of pinacidil induced arrhythmogenicity, neither SGLT2 inhibitor had a significant impact on cardiac electrophysiology. Conclusion In this model, empagliflozin and dapagliflozin demonstrated opposite antiarrhythmic properties.
Cardiac electrophysiologic and Cardiovascular involvement has long been important in the surveillance, care, and prognosis of patients with both BMD and DMD, and is the leading cause of mortality in patients with DMD.
The PRO portion of the currently featured PRO/CON debate between Dr. Brian Olshansky and Dr. John Mandrola presents a significant conundrum within the fields of electrophysiology and geriatric cardiology.
ABSTRACT Atrial flutter (AFL), defined as macro-re-entrant atrial tachycardia, is associated with debilitating symptoms, stroke, heartfailure, and increased mortality. Atypical AFL is a heterogenous group of re-entrant atrial tachycardias that most commonly occur in patients with prior heart surgery or catheter ablation.
In heartfailure with reduced ejection fraction and heartfailure with preserved ejection fraction, profound cellular and molecular changes have recently been documented in the failing myocardium.These changes include altered calcium handling and metabolic efficiency of the cardiac myocyte, reactivation of the fetal gene program, changes in the electrophysiological (..)
BACKGROUND:The relationship between heartfailure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF progressing to AF. Circulation, Ahead of Print. The pathophysiological basis of AF in the context of HF is presumed to result from atrial remodeling.
Myocardial calcium (Ca2+) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca2+ transient is linked to heartfailure and ventricular arrhythmias.
The overexpression of Cav1 reset the influence of vagotomy.ConclusionsWe found that LIPUS had a direct effect on regional antiinflammation and antifibrosis, improved cardiac autonomic function and heartfailure, protected the Cx43 (connexin43) protein, and reduced the risk of malignant arrhythmia during ICM.
HeartFailure 2024 Date: May 11-14, 2024 Location: Lisbon, Portugal and online Overview: The HeartFailure Congress stands as the premier global gathering encompassing the full spectrum of heartfailure. Hashtag: #ESCPrev2024 5. Hashtag: #HeartFailure2024 6.
Left bundle branch (LBB) area pacing (LBBAP) has become a cardiac resynchronization therapy (CRT) modality in patients with heartfailure (HF) and LBB block (LBBB). However, the electrophysiological differences between LBBP and LVSP and the methods to differentiate LBBP from LVSP in patients with HF and LBBB need investigations.
Brian Olshansky and John Mandrola currently featured presents a conundrum within the fields of electrophysiology and geriatric cardiology. The CON portion of the PRO/CON debate between Drs.
This study aimed to assess the electrophysiological characteristics of atrial fibrillation patients with dilated cardiomyopathy and compare the long-term clinical outcomes between patients undergoing catheter ablation and medical therapy.
Patients suffering from heart rhythm disorders are now being successfully treated with robotic ablation procedures using this advanced technology, and Hospital Santa Maria della Pietà is the first hospital in Italy to adopt the cutting-edge Genesis Robotic Magnetic Navigation (RMN) system. “As
This potential vascular market for this product family is measured in millions of procedures per year, including cardiac interventions such as structural heart procedures and electrophysiology procedures, peripheral vascular interventions including renal interventions, endovascular aortic repair, and carotid artery interventions.
ABSTRACT Background Despite leadless pacemakers (LPMs) showing promise, real-world data comparing them to transvenous pacemakers (TV-VVI) are insufficient and often contradictory, especially in patients without major comorbidities like heartfailure. Objectives Comparing LPMs with TV-VVIs in real-world patients without HF.
Abstract A vast amount of now well-established clinical and epidemiological data indicates a close, interdependent, and symbiotic association between atrial fibrillation (AF) and heartfailure (HF). Both AF and HF, when co-exist in a patient, have serious treatment and prognostic implications.
He also has New York Heart Association (NYHA) class II heartfailure with reduced ejection fraction and left ventricular ejection fraction (LVEF) 40%. PT is an 82-year-old man who presents with persistent, mildly symptomatic atrial fibrillation (AF) of approximately 4-5 months' duration.
The robotic technology represented an entirely novel way to address heart rhythm disorders in a minimally invasive procedure with the benefits of robotic precision and safety. When left untreated, arrhythmias may significantly increase the risk of stroke, heartfailure, and sudden cardiac arrest.
Central illustration: In this study comparing left bundle branch area pacing (LBBAP) versus endocardial resynchronization (Endo-CRT), both strategies were associated with a similar incidence of the composite outcome of heartfailure-related hospitalization and all-cause mortality.
Impact of preceding systolic heartfailure on risk of pacemaker-induced cardiomyopathy Abstract Background Pacemaker-induced cardiomyopathy is a well described phenomenon in patients with preserved ejection fraction at the time of permanent pacemaker implant.
BACKGROUND:Gene mutations are responsible for a sizeable proportion of cases of heartfailure. Circulation, Ahead of Print. However, the number of patients with any specific mutation is small.
ABSTRACT Background Atrial fibrillation (AF) recurrence remains a significant challenge in heartfailure with reduced ejection fraction (HFrEF) patients undergoing cryoballoon ablation (CBA). Secondary endpoints included all-cause mortality and heartfailure (HF)-related hospitalizations. vs. 39.4%, p =0.036).
Abstract Background Heartfailure (HF) with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are associated with high morbidity and mortality. Recently, sinus rhythm (SR) maintenance (SRM) after catheter ablation (CA) of AF (AFCA) in HFpEF has shown to reduce adverse events as compared to medical treatment.
Early treatment of persistent AF can reduce the risk of blood clots, stroke, and heartfailure, and may prevent the disease from becoming permanent. Patients are often treated with AADs as frontline therapy for heart rhythm maintenance, though some can experience adverse effects and limited efficacy.
Atrial fibrillation (AF) stands as the most prevalent cardiovascular disease, posing significant risks of stroke, heartfailure (HF), and other complications that contribute to morbidity and mortality.
In addition to these electrophysiological and reversible changes, which occur relatively early during AF, AF has been shown to be also associated with cardiac structural alterations including atrial dilatation and the development of heartfailure (2).
Africa is the second most populous and fastest growing continent, and yet has a nearly non-existent infrastructure of electrophysiology (EP) labs to provide cardiac ablation therapy. When left untreated, arrhythmias may significantly increase the risk of stroke, heartfailure, and sudden cardiac arrest. J Am Coll Cardiol EP.
Abstract Introduction Heartfailure (HF) and atrial fibrillation (AF) frequently co-exist. Contemporary classification of HF categorizes it into HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF).
The characterization of the cardiac autonomic nervous system has resulted in a new understanding and appreciation of neurocardiology, leading to potential novel neuromodulation therapies in clinical cardiology and cardiac electrophysiology. Patients with heartfailure may be improved clinically by potentiating parasympathetic tone.
24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Heartfailure–related admissions were higher in the RVAP group (22.6% BACKGROUND:Right ventricular apical pacing (RVAP) can produce left ventricle dysfunction. mm;P=0.04). versus 5.1%;P=0.03).CONCLUSIONS:Conduction
Circulation: Arrhythmia and Electrophysiology, Ahead of Print. BACKGROUND:A growing number of patients with tetralogy of Fallot develop left ventricular systolic dysfunction and heartfailure, in addition to right ventricular dysfunction.
Abstract Introduction Cardiac contractility modulation (CCM) is a medical device-based therapy delivering non-excitatory electrical stimulations to the heart to enhance cardiac function in heartfailure (HF) patients. The lack of human in vitro tools to assess CCM hinders our understanding of CCM mechanisms of action.
Abstract Left ventricular assist device (LVAD) implantation is an established treatment for patients with advanced heartfailure refractory to medical therapy. However, the incidence of ventricular arrhythmias (VAs) is high in this population, both in the acute and delayed phases after implantation.
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