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Nature Reviews Cardiology, Published online: 07 February 2025; doi:10.1038/s41569-025-01131-4 Hypertension is the leading cause of death globally but has low rates of diagnosis and treatment. In this Review, Dhaun and colleagues discuss the reasons for poor control of hypertension, such as therapeutic inertia and poor patient adherence, as well as novel pharmacological approaches to blood pressure lowering.
Researchers have used mathematical analysis tools to study the effect of classical music on a fetal heartbeat and identify patterns in heart rate variability. They recruited 36 pregnant women and played two classical pieces for their fetuses. By attaching external heart rate monitors, the researchers could measure the fetal heart rate response to both songs, and by employing nonlinear recurrence quantification analysis, they could identify changes in heart rate variability during and after the m
It is possible to reduce your risk of heart disease by over 90% 1. Let me show you how. But first, let’s get some facts straight. Over a long enough time frame, pretty much everyone will get heart disease. By the time you get to age 80, you will almost certainly have evidence of plaque in your coronary arteries - you will have heart disease. But remember: Heart disease doesn’t kill people.
Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). However, its definition varies vastly among studies, leading to different attributions to the variable dyslipidemia. The objectives of this study are to verify the hypothesis of a lack of a consensual definition of dyslipidemia in coronary angiography studies and to propose a consensual definition of dyslipidemia, considering the influence of each serum lipid paramet
Understanding cell fate regulation in the liver is necessary to advance cell therapies for hepatic disease. Liver progenitor cells (LPCs) contribute to tissue regeneration after severe hepatic injury, yet signals instructing progenitor cell dynamics and fate are largely unknown. Tissue inhibitor of metalloproteinases 1 (TIMP1) and TIMP3 control the sheddases ADAM10 and ADAM17, key for NOTCH activation.
Nature Reviews Cardiology, Published online: 03 February 2025; doi:10.1038/s41569-025-01132-3 In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and th
Journal of the American Heart Association, Ahead of Print. Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF.
At Cardiomatics, we are committed to advancing cardiac research with AI-driven ECG analysis. We are proud to share our latest study, conducted with University Hospital Basel, and published in Diabetes Care. This marks our fourth collaboration, and we are eager to do more! The study explores how metformin can protect against the harmful effects of glucocorticoids (GCs).
At Cardiomatics, we are committed to advancing cardiac research with AI-driven ECG analysis. We are proud to share our latest study, conducted with University Hospital Basel, and published in Diabetes Care. This marks our fourth collaboration, and we are eager to do more! The study explores how metformin can protect against the harmful effects of glucocorticoids (GCs).
Disruptions of blood pressure (BP) circadian variation are closely associated with an increased risk of cardiovascular disease. Thus, gaining insights into the molecular mechanisms of BP circadian variation is essential for comprehending BP regulation. Human genetic analyses suggest that PR domaincontaining protein 16 (PRDM16), a transcription factor highly expressed in vascular smooth muscle cells (VSMCs), is significantly associated with BP-related traits.
Low-density lipoproteins (LDL) -- commonly known as bad cholesterol -- have long been on scientists' radar as a major contributor to heart disease. But these microscopic troublemakers have hidden their inner workings behind a maze of complexity. That is, until now. Researchers have now revealed the specific shape and structure of one of the body's most important yet complicated proteins: ApoB100.
It seems even interventional cardiologists arent immune to the Weekend Effect as a recent study suggests patients admitted on weekends for TAVR procedures face significantly higher risks. The “weekend effect” is a well-documented phenomenon in hospital care, often linked to reduced staffing levels, leading to potential delays in diagnosis and intervention.
This week marked week 1 of my 12-week marathon training block which I’m referring to as the “Road to Boston.” Each week I’ll share details about my training, some insights, and other musings as I train for the 2025 Boston Marathon. Thanks for following along! You can also find my training on Strava. Physiologically Speaking is a reader-supported publication.
Background Left ventricular diastolic function as assessed by tissue Doppler echocardiography predicts cardiovascular event rates at 4 years of follow-up in patients with hypertension. Our aim was to evaluate whether this extends to predicting cardiovascular mortality after 20 years of follow-up. Methods Conventional (E) and tissue Doppler (e') echocardiography was performed on hypertensive participants in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) with long-term follow-up ascertained
Women who have experienced pregnancy complications have an increased risk of cardiovascular disease. Now, a new study shows that sisters of women with complicated pregnancies are also at higher risk, even if they had uncomplicated pregnancies. The findings suggest that genes and shared environmental factors may influence the association between pregnancy complications and cardiovascular disease risk.
Sooner certainly seems to be better than later when it comes to treating LDL-C levels with the PCSK9 inhibitor evolocumab (Amgen’s Repatha), and according to a recent JACC study , thats especially true for older patients. People aged 75 years make up ~65% of all deaths linked to cardiovascular disease, with age being one of the primary risk factors for ASCVD.
tim.hodson Mon, 02/03/2025 - 12:30 January 29, 2025 Roche announced today that the Tina-quant Lipoprotein (a) Gen.2 Molarity assay has received 510(k) clearance from the United States Food and Drug Administration (FDA). This will be the first 510(k) cleared test of its kind available in the U.S. measuring lipoprotein (a), or Lp(a), in nanomoles per liter (nmol/L).
The 2025 American Heart Association statistics were published recently, and heart disease remains the leading cause of death in the US and globally 1. The good news is that heart disease at younger ages is largely preventable. High cholesterol is a core to heart disease development and can usually be easily managed. With this approach, the future risk of heart disease can be significantly reduced.
ObjectiveTo explore the risk factors for cardiotoxicity in patients with gastrointestinal (GI) tumors treated with fluorouracil drugs.MethodsThis study included patients with GI tumors who received fluorouracil at our hospital between January 2018 and April 2022. The demographic and clinical characteristics were collected. The risk factors associated with the cardiotoxicity of fluorouracil were explored using multivariable logistic regression.ResultsA total of 300 patients were finally included
Taylor receiving ACC's 2024 Pamela S. Douglas Award for Diversity and Inclusion at ACC.24 in Atlanta, GA. Herman A. Taylor's, MD, FACC, pioneering career in cardiovascular medicine has been characterized by a lot of change, but his commitment to improving the health of all patients has remained constant, thanks in part to his grandmother who reminded him early in his career that health is one of life's greatest blessings.
Background The present study aimed to critically revise the published literature on clinical outcomes and cost-effectiveness of Inspiris Resilia valve. Methods This work was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Full text research articles discussing clinical or cost-effectiveness aspects of Inspiris Resilia bioprosthesis published in English were included in this analysis.
Large Language Models (LLM) are increasingly multimodal, and Zero-Shot Visual Question Answering (VQA) shows promise for image interpretation. If zero-shot VQA can be applied to a 12-lead electrocardiogram (ECG), a prevalent diagnostic tool in the medical field, the potential benefits to the field would be substantial. This study evaluated the diagnostic performance of zero-shot VQA with multimodal LLMs on 12-lead ECG images.
tim.hodson Tue, 02/04/2025 - 17:13 Feb. 3, 2025 Today, Peripheral Artery Disease (PAD)affects 10 million Americans and is the most common cause of limb amputation outside of trauma. Yet, 70 percent of Americans dont know what it is or what signs to look for. During American Heart Month, the PAD Pulse Alliance, a coalition of four leading medical societies dedicated to improving vascular health, is raising awareness of PAD and providing resources for people to learn more about it.
HCPLive spoke with Sachs about his study on palliative care for dementia, which reduced ED visits but didnt significantly improve neuropsychiatric symptoms.
In recent years, numerous health care challenges have been tackled, some making headlines, while others quietly escalate under the radar – like polypharmacy. Cardiovascular medications frequently lead this category, often contributing to adverse clinical outcomes, including emergency department visits and hospitalizations. As clinicians, we're caught between evidence-based guidelines and the need for individualized care, a balance that's even more delicate with older adults.
BackgroundPHACE syndrome is an uncommon disorder, marked by large segmental hemangiomas on the face and various developmental anomalies. Significant advancements have been made in its diagnosis, imaging, and understanding of complications since 1996.Case SummaryWe describe the first diagnosis case of PHACE syndrome in a one-month and 19-day-old infant who presented with a large facial hemangioma and coarctation of the aorta originating from the left common carotid artery, along with an aberrant
Research Highlights: Mechanically retrieving a blood clot blocking a medium- or small-sized brain artery was no better at reducing disability 90 days after a stroke than standard care alone (including clot-busting medication if indicated). While.
New research shows that women who hit menopause later in life have healthier blood vessels and mitochondria and a different composition of metabolites in their blood than those who stop menstruating earlier. The study helps explain why late-onset menopause is linked to lower risk of heart attacks and strokes.
The exact role of subcutaneous adipose tissue in the interplay between type 2 diabetes (T2D) and coronary artery disease (CAD) is yet to be determined. A prospective cohort study of adult patients with and without T2D undergoing CABG was performed. Subcutaneous adipose tissue was collected during the procedure and RNA seq analysis was performed. A total of 741 differentially expressed genes (DEGs) were identified (332 up- and 409 down-regulated in the T2D group).
The future of medical imaging is about connection. Today’s healthcare challenges demand platforms that unify radiology, cardiology, digital pathology, genomics, and beyond into a seamless enterprise ecosystemmoving past the era of standalone systems and isolated workflows. A complete enterprise imaging solution allows us to move closer to an improved multidisciplinary collaboration, and a more comprehensive patient overview.
It may not have caught any healthcare industry leaders by surprise when heart disease and stroke continued to top the list of leading causes of death in the U.S. in 2022. The average $417.9 billion annual price tag for the diseases may not have caused some hospital officials to bat an eye, either. But one Cleveland Clinic expert is imploring executives not to look away.
Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes.
(MedPage Today) -- The age of type 2 diabetes patients may alter the level of cardioprotection from two newer classes of anti-diabetic agents, a network meta-analysis suggested. The relative reduction in major adverse cardiovascular events (MACE.
Though a rare condition, acute type A aortic dissection (ATAAD) is associated with high morbidity and mortality; hence, timely diagnosis and surgery are important to reduce the risk of mortality. If the dissection extends into the aortic arch branches, ensuring adequate cerebral perfusion during surgery is crucial to preventing stroke. A 50-year-old man presented to the emergency department with symptoms of acute chest pain, dizziness, and headache.
IntroductionClinical evidence highlighting the efficacy and safety of transcatheter aortic valve replacement (TAVR) and the 2019 Food and Drug Administration (FDA) approval for TAVR in low-risk (younger) patients has created a demand for durable and long-lasting bioprosthetic heart valve (BHV) leaflet materials. Over the life of an implanted BHV mechanical stress, immunogenicity, calcification, and hemodynamic dysfunction lead to failure via structural valve deterioration (SVD).
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