Sat.Jun 15, 2024 - Fri.Jun 21, 2024

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Is Cholesterol Denialism Pseudoscience or Appropriate Medical Care?

Med Page Today

(MedPage Today) -- Recently, a cardiologist published a commentary in Medscape arguing that physicians and scientists who challenge the putative clinical benefit of statin medications are pseudoscientists. He claimed, ".somewhere along the way.

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Another deadly triage ECG missed, and the waiting patient leaves before being seen. What is this nearly pathognomonic ECG?

Dr. Smith's ECG Blog

Written by Bobby Nicholson, MD 67 year old male with history of hypertension and hyperlipidemia presented to the Emergency Department via ambulance with midsternal nonradiating chest pain and dyspnea on exertion. Pain improved to 1/10 after EMS administers 324 mg aspirin and the following EKG is obtained at triage. What do you think? If this EKG were handed to you to screen from triage without any clinical information, what would you think?

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Hot enough for ya? It may be too hot for your heart health!

American Heart News - Heart News

DALLAS, June 20, 2024 — It’s only the first day of summer and record high temperatures are already being reported across much of the U.S. That’s prompted the American Heart Association, celebrating a century of lifesaving service as the world’s leading.

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Women who experience depression during pregnancy or after birth have higher risk of cardiovascular disease

Science Daily - Heart Disease

Women diagnosed with perinatal depression are more likely to develop cardiovascular disease in the following 20 years compared to women who have given birth without experiencing perinatal depression. The study is the first of its kind to look at cardiovascular health after perinatal depression and included data on around 600,000 women. It found the strongest links with risks of high blood pressure, ischemic heart disease and heart failure.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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FDA Approves Risankizumab (Skyrizi) for Ulcerative Colitis

HCPLive

The approval is based on data from a pair of phase 3 studies and makes risankizumab-rzaa the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn’s disease.

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How Does Heat Kill? It Confuses the Brain, Shuts Down Organs, and Strains the Heart.

Med Page Today

(MedPage Today) -- As temperatures and humidity soar outside, what's happening inside the human body can become a life-or-death battle decided by just a few degrees. The critical danger point outdoors for illness and death from relentless heat.

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Over-the-counter supplement found to improve walking for peripheral artery disease patients

Medical Xpress - Cardiology

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Can gardening ward off heart attacks?

Heart Sisters

This study looked at what gardeners already suspect: "Gardening is associated with better cardiovascular health among older adults compared to older adults who do not garden"

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ECG Cases 50 – STEMI: A Failed Paradigm, Enter Occlusion MI

ECG Cases

Dr. Jesse McLaren illustrates the paradigm shift from STEMI to Occlusion MI (OMI) through 9 cases, and drives home the points that if there is STEMI criteria, consider false positives (eg. secondary and proportional to LVH or BER); if there is no STEMI criteria, consider false negatives and look for other signs of occlusion (eg. acute Q waves or loss of R waves, hyperacute T waves, or reciprocal STD/TWI) and if the ECG is nondiagnostic, consider other OMI signs including clinical (refractory isc

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Tech in Diabetes: What's Going Wrong?

Med Page Today

(MedPage Today) -- ORLANDO -- Technologic advances aren't fulfilling their promise for improving diabetes or overall health outcomes in the U.S., argued FDA Commissioner Robert Califf, MD. "We are wowing the world in technology -- much of.

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Robert Gish, MD: Advancements in Therapeutic Development, Combination Therapy in PBC

HCPLive

Gish explains recent developments in the treatment of PBC, highlighting the FDA approval of elafibranor, the anticipated decision for seladelpar, and the growing role of combination therapy.

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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

American Heart News - Heart News

Research Highlights: The number of individuals in the United States who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021, according to a nationwide review of private health insurance.

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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

Science Daily - Heart Disease

The number of individuals in the U.S. who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021.

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Perinatal Depression Tied to Increased Risk of Midlife Cardiovascular Disease

Med Page Today

(MedPage Today) -- Women with perinatal depression (PND) had a higher risk of cardiovascular disease (CVD) in middle adulthood than matched parous women without PND, a Swedish nationwide study found. Over a mean of 10.4 years, women with PND had.

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Fenofibrate Markedly Lowers Progression of Diabetic Retinopathy

HCPLive

A first-time trial presented at ADA 2024 found the common cholesterol-lowering drug halts vision loss in patients with diabetic eye disease.

Diabetes 115
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Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study

Cardiovascular Diabetology

To evaluate the association between diabetic foot disease (DFD) and the incidence of fatal and non-fatal events in individuals with type 2 diabetes (T2DM) from primary-care settings.

Diabetes 115
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Research finds causal evidence tying cerebral small-vessel disease to Alzheimer's, dementia

Science Daily - Heart Disease

While previous studies suggested an association of the most common cerebral small-vessel disease with dementia risk, new research provides evidence of causal link, identifying it as a major vascular factor.

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Lupus Complications Reduced With Common Diabetes Drug

Med Page Today

(MedPage Today) -- People with systemic lupus erythematosus (SLE) had lower rates of lupus nephritis, chronic kidney disease, and other complications when they were taking metformin, an analysis of medical records indicated. Among some 88,000.

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Over-the-counter supplement improves walking for peripheral artery disease patients

Science Daily - Stroke

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Engineers develop face screening tool that detects stroke in seconds

Medical Xpress - Cardiology

A new smartphone face-screening tool could help paramedics to identify stroke in seconds—much sooner and more accurately than is possible with current technologies.

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Study Finds Air Pollution Can Increase Cardiovascular Risk for Cancer Patients

DAIC

Getty Images milla1cf Wed, 06/19/2024 - 20:54 June 19, 2024 — Modern therapies have extended the lives of many cancer patients; however, survivors often live with chronic health conditions, including cardiovascular disease. New research published in JACC: CardioOncology shows that air pollution plays a significant role in increasing cardiovascular disease and mortality in cancer patients and contributes to health disparities related to these conditions.

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Rise in Chronic Hypertension in Pregnancy While Treatment Stagnates

Med Page Today

(MedPage Today) -- There was a steady increase in the prevalence of chronic hypertension in pregnancy over the last two decades, with some accompanying changes in treatment, a nationwide cohort study found. From 2008 to 2021, the prevalence of.

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Intensive Blood Pressure Control in Individuals With Hypertension

JAMA Cardiology

This randomized clinical trial investigates the effectiveness and safety of a nonphysician-led, multifaceted, intensive blood pressure intervention in younger and older individuals with hypertension.

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Researchers say AI accurately screens heart failure patients for clinical trial eligibility

Medical Xpress - Cardiology

Generative Artificial Intelligence (Gen AI) can rapidly and accurately screen patients for clinical trial eligibility, according to a new study from Mass General Brigham researchers. Such technology could make it faster and cheaper to evaluate new treatments and, ultimately, help bring successful ones to patients.

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JACC Report Card Highlights Inequities in CV Care, Death Rates

DAIC

Getty Images milla1cf Tue, 06/18/2024 - 19:56 June 18, 2024 — As we commemorate Juneteenth 2024, JACC , the flagship journal of the American College of Cardiology , has published “Excess Cardiovascular Mortality Among Black Americans 2000-2022: A Report Card,” to highlight the persistent and tragic inequities in cardiovascular care and put in human terms the years of life lost to the Black community because of their higher cardiovascular disease death rates.

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Unlocking heart health: Advancing noninvasive monitoring in chimpanzees

Science Daily - Heart Disease

Measuring the heart rate of great apes in captivity is essential for both health management and animal studies. However, existing most methods are either invasive or inaccurate. Now, researchers have investigated the potential of using millimeter-wave radar technology to estimate heart rate from subtle body movements in chimpanzees. Their efforts will hopefully pave the way to better practices and techniques for monitoring heart rates in wild and captive primates.

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RNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction

JAMA Cardiology

This genetic association study evaluated genetic variants associated with increased risk of vasospastic angina.

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Cardiac Shockwave Device Passes Hurdle in Ischemic Cardiomyopathy

Med Page Today

(MedPage Today) -- As an adjunct to bypass surgery for ischemic cardiomyopathy, a cardiac shockwave therapy aimed at regenerating ischemic myocardium boosted left ventricular ejection fraction (LVEF) and physical function at 1 year in a small sham.

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Novel Tricuspid Valve Procedure Improves Patients' Quality of Life and Health Status

DAIC

milla1cf Fri, 06/21/2024 - 20:10 June 21, 2024 — UC San Francisco interventional cardiologists and interventional echocardiographers recently performed the health system’s first commercial transcatheter tricuspid valve replacement procedure using the Edwards EVOQUE system. The novel and minimally invasive cardiac procedure was recently approved for use within the U.S. by the Food and Drug Administration.

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TNX-102 SL Significantly Reduces Daily Pain, Improves Fibromyalgia Symptoms

HCPLive

At EULAR, Tonix Pharmaceuticals presented the phase 3 RESILIENT trial which met the primary endpoint of TNX-102 SL reducing daily pain intensity.

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CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 inhibitor and is activated primarily after being metabolized by a highly polymorphic hepatic cytochrome CYP2C219 enzyme.

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New therapy shows promise in treating hypertension-induced organ damage

Medical Xpress - Cardiology

A team of researchers led by Monash University and the Baker Heart and Diabetes Institute have published the first compelling evidence of the therapeutic potential of a new therapy to treat hypertension-induced organ damage. The paper appears in the journal Cardiovascular Research.

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Microbot Medical Partners with Brigham and Women's Hospital for Its Pivotal Human Clinical Trial

DAIC

milla1cf Thu, 06/20/2024 - 19:42 June 20, 2024 — Microbot Medical Inc. announced its agreement with Brigham and Women’s Hospital ( BWH ), a leading academic medical center located in Boston, Massachusetts, to serve as one of the sites to perform the pivotal human clinical trial for its LIBERTY Endovascular Robotic Surgical System , as part of its Investigational Device Exemption (“IDE”) application.

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Biological Agents Reduce PsA Risk More Than Methotrexate in Psoriasis

HCPLive

Patients with psoriasis on biological agents might have a lower PsA risk than those on methotrexate, but patients on topical therapy have an even lower risk, a study found.

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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

Journal of Clinical Investigation - Cardiology

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase secretory pathway Ca2+ transporting 1 (ATP2C1).

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Vessel-Level Coronary Atherosclerotic Plaque Activity Predicts Myocardial Infarction Risk

Cardiology Update

Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Recent research has illuminated the role of total coronary atherosclerotic plaque activity across the entire coronary arterial tree in predicting patient-level clinical outcomes. However, the association between vessel-level coronary atherosclerotic plaque activity and the incidence of vessel-level myocardial infarction (MI) has not been fully explored.