Sat.Jan 27, 2024 - Fri.Feb 02, 2024

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3 ways to drive awareness of women’s greatest health threat for American Heart Month

American Heart News - Heart News

DALLAS, Feb. 1, 2024 – From news desks to iconic buildings, scores of people and landmarks across the U.S. will once again “go red” on National Wear Red Day, Feb. 2, to raise awareness that cardiovascular disease is the No. 1 killer of women and support.

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Ultra-processed foods and cardiovascular disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 30 January 2024; doi:10.1038/s41569-024-00990-7 In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.

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Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations

Journal of Clinical Investigation - Cardiology

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site–directed biopsies, and multiomics analyses to define metabolic drivers of invasive glioblastoma cells.

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What is this ECG finding? Do you understand it before you hear the clinical context?

Dr. Smith's ECG Blog

Written by Pendell Meyers First try to interpret this ECG with no clinical context: The ECG shows an irregularly irregular rhythm, therefore almost certainly atrial fibrillation. After an initially narrow QRS, there is a very large abnormal extra wave at the end of the QRS complex. These are Osborn waves usually associated with hypothermia. There is also large T wave inversion and long QT.

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Some 'Choosing Wisely' Recs Protect Older Folks From Low-Value Care

Med Page Today

(MedPage Today) -- Getting clinicians to commit to the Choosing Wisely recommendations somewhat reduced low-value care for older adults in common scenarios, a cluster randomized trial found. After primary care clinicians committed in writing to.

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New evidence informs risk factors, diagnosis and care of patients with CVT stroke

American Heart News - Stroke News

DALLAS, January 29, 2024 — A new scientific statement from the American Heart Association emphasizes the need to increase patients’ and physicians’ awareness of cerebral venous thrombosis (CVT) to improve the recognition of this condition and initiate.

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KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Journal of Clinical Investigation - Cardiology

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBRA protein levels in cerebrospinal fluid are associated with cognitive impairment and pathological tau levels in disease.

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Caution Raised for Post-TAVR Cardiac Surgeries

Med Page Today

(MedPage Today) -- SAN ANTONIO -- The early experience of patients needing cardiac surgery after transcatheter aortic valve replacement (TAVR) has surgeons raising the alarm about the excess risks of these challenging procedures, based on data.

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Neurons can feel the pulse in the brain, study shows

Medical Xpress - Cardiology

As opposed to the sensory perception of the external world, interoception is the sensing of internal body signals, which informs the brain about the state of the body. Rhythmic bodily processes such as breathing, the heartbeat, or the pulsing of the gut may help keep brain activity organized. Indeed, it seems that how we think and see the world is affected by our heartbeat.

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Biofilm-derived oxylipin 10-HOME–mediated immune response in women with breast implants

Journal of Clinical Investigation - Cardiology

This study investigates a mechanistic link of bacterial biofilm–mediated host-pathogen interaction leading to immunological complications associated with breast implant illness (BII). Over 10 million women worldwide have breast implants. In recent years, women have described a constellation of immunological symptoms believed to be related to their breast implants.

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How 72-Week Data Informs Nephrologists on Potential of Atacicept in IgA Nephropathy, with Richard Lafayette, MD

HCPLive

In the wake of Vera Therapeutics announcing positive 72-week data from the phase 2b ORIGIN trial, we sat down with lead investigator Richard Lafayette, MD, to learn more about how he interprets the latest data from the atacicept program in IgA nephropathy.

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Exposure to even moderate levels of radon linked to increased risk of stroke

Science Daily - Heart Disease

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations.

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Breakthrough Research Identifies Predictors of Venous Thromboembolism after Pulmonary Resection for Lung Cancer

DAIC

milla1cf Mon, 01/29/2024 - 14:26 January 29, 2024 — In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE)—a condition that develops when a blood clot forms in a vein—which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).

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PD-1H/VISTA mediates immune evasion in acute myeloid leukemia

Journal of Clinical Investigation - Cardiology

Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti–programmed cell death protein (anti-PD) therapy. We demonstrate that programmed death-1 homolog (PD-1H), an immune coinhibitory molecule, is highly expressed in blasts from the bone marrow of AML patients, while normal myeloid cell subsets and T cells express PD-1H.

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Reflecting on the 1964 Surgeon General Report with Viet Le, DMSc, PA-C

HCPLive

In recognition of 60 years since the historic contribution to modern understanding of the harmful effects of cigarette smoking, Albert Rizzo, MD, meets with the preventive cardiology expert to discuss the myriad of cascading effects delivered by the 1964 report.

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Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus

Cardiovascular Diabetology

Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index.

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Impact of untreated CAD on TAVR outcomes

Cardiology Update

The optimal management of concomitant chronic obstructive coronary artery disease (CAD) in transcatheter aortic valve replacement (TAVR) recipients remains a debated topic. While some advocate for pre-TAVR percutaneous coronary intervention, others adopt an expectant approach. In a recent study published in the European Heart Journal, researchers investigated the influence of varying degrees and extent of untreated chronic obstructive CAD on TAVR outcomes and longer-term results.

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One Class of Antidiabetic Linked With Lower Kidney Stone Risk

Med Page Today

(MedPage Today) -- One class of glucose-lowering agent may help lower the risk of kidney stones in adults with type 2 diabetes, a cohort study suggested. Adults who newly started on an SGLT2 inhibitor had a 31% lower risk of nephrolithiasis compared.

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Women With Alcohol-Related Liver Disease Face Greater Risk of Mortality Than Men

HCPLive

Although there was a greater prevalence of ALD and MetALD among male study participants, females had a greater risk of mortality from both SLD phenotypes, highlighting a potentially greater impact of alcohol consumption on women with liver disease than men.

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Stroke or stroke plus neck artery tear almost doubled risk of heart attack within a year

American Heart News - Heart News

Research Highlights: The risk of a heart attack among adults after a clot-caused stroke or a stroke plus a tear in the wall of a neck artery (carotid or vertebral artery dissection) was almost double within the first year compared to the heart attack.

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New Philips Mini TEE Ultrasound Transducer Helps Improve Cardiac Care for More Patients

DAIC

milla1cf Wed, 01/31/2024 - 17:10 January 31, 2024 — Royal Philips , a global leader in health technology, announced that its latest TEE transducer, designed to serve more patients with improved overall comfort, has received FDA 510(k) clearance. Cardiovascular ultrasound has played a key role in the evolution of early diagnosis of structural heart disease, led by a technology pioneered by Philips: the ‘transesophageal echocardiography’ (TEE) ultrasound transducer.

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Exercise training outcomes in patients with chronic heart failure with reduced ejection fraction depend on patient background

Frontiers in Cardiovascular Medicine

Background The aim of this study was to identify significant factors affecting the effectiveness of exercise training using information of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) study. Methods Background factors influencing the effect of exercise training were comprehensively surveyed for 2,130 patients by multivariable Cox regression analysis with the stepwise variable selection, and only significant factors were selected that were statisti

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Laser Flare Photometry Successfully Identifies JIA-Associated Uveitis

HCPLive

Of the 135 laser flare photometry readings to identify uveitis among patients with juvenile idiopathic arthritis, only 3% were characterized as a false positive.

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Active components of ginkgo biloba may improve early cognitive recovery after stroke

American Heart News - Stroke News

Research Highlights: In a study conducted in China, adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) — a combination of biologically active components of ginkgo biloba — after an ischemic (clot-caused).

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Boston Scientific Receives FDA Approval for FARAPULSE Pulsed Field Ablation System

DAIC

The U.S. Food and Drug Administration (FDA), has granted approval to Boston Scientific for its FARAPULSE Pulsed Field Ablation System. A company statement reported that its PFA System is indicated for the isolation of pulmonary veins in the treatment of drug-refractory, recurrent, symptomatic, paroxysmal (i.e., intermittent) atrial fibrillation (AF) and is a unique new alternative to standard-of-care thermal ablation treatment.

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Drug-Related Endocarditis: A First Stab at Recommendations for Surgeons

Med Page Today

(MedPage Today) -- SAN ANTONIO -- In response to the opioid epidemic, a primer to treating infective endocarditis (IE) specifically related to drug use was released by the Society of Thoracic Surgeons (STS). A workforce on the surgical management.

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Peripheral Apoptotic Lymphocytes May Predict Disease Activity in Juvenile SLE

HCPLive

The percentage of lymphocyte apoptosis in peripheral blood was significantly higher in patients with jSLE when compared with healthy controls.

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Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

Journal of Clinical Investigation - Cardiology

Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis (0NASH) and fibrosis. The mechanisms that prevent NASH and fibrosis in the majority of patients with NAFLD remain unclear. Here, we report that NAD(P)H oxidase 4 (NOX4) and nuclear factor erythroid 2–related factor 2 (NFE2L2) were elevated in hepatocytes early in disease progression to prevent NASH and fibrosis.

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W. L. Gore Receives FDA Approval for Lower Profile Gore Viabahn VBX Balloon Expandable Endoprosthesis

DAIC

GORE VIABAHN VBX Balloon Expandable Endoprosthesis milla1cf Wed, 01/31/2024 - 17:04 January 31, 2024 — As part of efforts to continuously improve medical solutions for patients with complex vascular disease, W. L. Gore & Associates, Inc. (Gore) announced recent FDA approval of a lower profile GORE VIABAHN VBX Balloon Expandable Endoprosthesis ( VBX Stent Graft ).

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Nerve stimulation plus intense rehab may improve arm and hand function after stroke

American Heart News - Stroke News

Research Highlights: Stimulating a nerve that runs between various organs and the brain with intense physical rehabilitation improved arm and hand function in people with stroke. The improved motor function remained at the end of the one-year.

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Chest pain and a computer ‘normal’ ECG. Therefore, there is no need for a physician to look at this ECG.

Dr. Smith's ECG Blog

Written by Jesse McLaren, comments by Smith A 55 year old with a history of NSTEMI presented with two hours of exertional chest pain, with normal vitals. Below is the triage ECG, with a computer interpretation (Marquette 12 SL) of “normal” which was confirmed by the over-reading cardiologist. What do you think? Should this patient continue to stay in the waiting room, without interruption of the physician to interpret the ECG, because the computer interpretation is normal?

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Obesity Associated With Renal Function Decline, Kidney Disease Risk

HCPLive

Obesity was linked to an increased risk of focal segmental glomerulosclerosis and hypertensive nephropathy, with further analysis revealing its impact on the risk of developing end-stage kidney disease.

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STS Announces Late-breaker Research to Be Presented at the 2024 Annual Meeting

DAIC

milla1cf Mon, 01/29/2024 - 11:00 January 29, 2024 — The Society of Thoracic Surgeons has released late-breaking research scheduled for presentation at the 2024 Annual Meeting taking place January 27 - 29 in San Antonio. The conference, healthcare’s leading scientific and educational convening specializing in cardiothoracic surgery, has a rich history of showcasing clinical trials with a strong foundation of detailed methodology and trusted data collection governed by ethical clinical principles.

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New clot-busting medication simplified stroke treatment in specialized ambulance

American Heart News - Stroke News

Research Highlights: Compared with the standard medication alteplase, the newer clot-busting medication tenecteplase may offer a safe, effective and simpler way to treat clot-caused stroke in special ambulances called mobile stroke units. Tenecteplase.

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Unraveling the Link Between Mental Health and Cardiovascular Disease 

Cardiometabolic Health Congress

The profound link between the heart and mind has been the subject of much research for some time, with newer studies reinforcing the existing evidence as well as offering deeper insights. A large number of studies have shown that individuals coping with conditions like depression, anxiety, or stress face an elevated risk of cardiovascular problems. Past studies have often attributed this association to behavioral aspects, such as a person coping with emotional distress through smoking or drinkin

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eGFR Based on Creatinine, Cystatin C May Offer Better CKD Threshold for Older Adults

HCPLive

Low eGFRcr-cys was more strongly and uniformly associated with adverse outcomes compared to low eGFRcr in an older patient population, highlighting the benefit of including cystatin C in GFR estimation.

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Almost 50% of Patients Under 60 Years Choose TAVR Over Surgical Aortic Valve Replacement with Worse Outcomes

DAIC

Getty Images milla1cf Mon, 01/29/2024 - 14:24 January 29, 2024 — Despite national guidelines recommending surgical aortic valve replacement (SAVR) for patients under age 65 with severe aortic stenosis , many hospitals are still opting for a nonsurgical approach in patients under 60—possibly with poorer survival rates. In a study presented at The Society of Thoracic Surgeons’ 2024 Annual Meeting in San Antonio, Texas, researchers from the department of cardiac surgery in the Smidt Heart I