Sat.Jan 27, 2024 - Fri.Feb 02, 2024

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3 ways to drive awareness of women’s greatest health threat for American Heart Month

American Heart News - Heart News

DALLAS, Feb. 1, 2024 – From news desks to iconic buildings, scores of people and landmarks across the U.S. will once again “go red” on National Wear Red Day, Feb. 2, to raise awareness that cardiovascular disease is the No. 1 killer of women and support.

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Ultra-processed foods and cardiovascular disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 30 January 2024; doi:10.1038/s41569-024-00990-7 In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.

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Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations

Journal of Clinical Investigation - Cardiology

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site–directed biopsies, and multiomics analyses to define metabolic drivers of invasive glioblastoma cells.

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Caution Raised for Post-TAVR Cardiac Surgeries

Med Page Today

(MedPage Today) -- SAN ANTONIO -- The early experience of patients needing cardiac surgery after transcatheter aortic valve replacement (TAVR) has surgeons raising the alarm about the excess risks of these challenging procedures, based on data.

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New evidence informs risk factors, diagnosis and care of patients with CVT stroke

American Heart News - Stroke News

DALLAS, January 29, 2024 — A new scientific statement from the American Heart Association emphasizes the need to increase patients’ and physicians’ awareness of cerebral venous thrombosis (CVT) to improve the recognition of this condition and initiate.

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Promising heart drugs ID'd by cutting-edge combo of machine learning, human learning

Science Daily - Heart Disease

Scientists have developed a new approach to machine learning -- a form of artificial intelligence -- to identify drugs that help minimize harmful scarring after a heart attack or other injuries.

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KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Journal of Clinical Investigation - Cardiology

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBRA protein levels in cerebrospinal fluid are associated with cognitive impairment and pathological tau levels in disease.

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E-Cigarettes As Effective as Varenicline, More Effective Than Nicotine Gum in Helping to Quit Smoking

HCPLive

This new research may require additional follow up studies on potential harms, as 63% of those in this study’s electronic cigarette arm continue to use the product at 6 months.

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Machine learning informs a new tool to guide treatment for acute decompensated heart failure

Science Daily - Heart Disease

A recent study utilized a machine learning-based approach to identify, understand, and predict diuretic responsiveness in patients with acute decompensated heart failure (ADHF).

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Biofilm-derived oxylipin 10-HOME–mediated immune response in women with breast implants

Journal of Clinical Investigation - Cardiology

This study investigates a mechanistic link of bacterial biofilm–mediated host-pathogen interaction leading to immunological complications associated with breast implant illness (BII). Over 10 million women worldwide have breast implants. In recent years, women have described a constellation of immunological symptoms believed to be related to their breast implants.

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One Class of Antidiabetic Linked With Lower Kidney Stone Risk

Med Page Today

(MedPage Today) -- One class of glucose-lowering agent may help lower the risk of kidney stones in adults with type 2 diabetes, a cohort study suggested. Adults who newly started on an SGLT2 inhibitor had a 31% lower risk of nephrolithiasis compared.

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Neurons can feel the pulse in the brain, study shows

Medical Xpress - Cardiology

As opposed to the sensory perception of the external world, interoception is the sensing of internal body signals, which informs the brain about the state of the body. Rhythmic bodily processes such as breathing, the heartbeat, or the pulsing of the gut may help keep brain activity organized. Indeed, it seems that how we think and see the world is affected by our heartbeat.

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Exposure to even moderate levels of radon linked to increased risk of stroke

Science Daily - Heart Disease

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations.

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PD-1H/VISTA mediates immune evasion in acute myeloid leukemia

Journal of Clinical Investigation - Cardiology

Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well as modern therapeutics, such as targeted therapy and immunotherapy, including anti–programmed cell death protein (anti-PD) therapy. We demonstrate that programmed death-1 homolog (PD-1H), an immune coinhibitory molecule, is highly expressed in blasts from the bone marrow of AML patients, while normal myeloid cell subsets and T cells express PD-1H.

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Drug-Related Endocarditis: A First Stab at Recommendations for Surgeons

Med Page Today

(MedPage Today) -- SAN ANTONIO -- In response to the opioid epidemic, a primer to treating infective endocarditis (IE) specifically related to drug use was released by the Society of Thoracic Surgeons (STS). A workforce on the surgical management.

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Chest pain and a computer ‘normal’ ECG. Therefore, there is no need for a physician to look at this ECG.

Dr. Smith's ECG Blog

Written by Jesse McLaren, comments by Smith A 55 year old with a history of NSTEMI presented with two hours of exertional chest pain, with normal vitals. Below is the triage ECG, with a computer interpretation (Marquette 12 SL) of “normal” which was confirmed by the over-reading cardiologist. What do you think? Should this patient continue to stay in the waiting room, without interruption of the physician to interpret the ECG, because the computer interpretation is normal?

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How 72-Week Data Informs Nephrologists on Potential of Atacicept in IgA Nephropathy, with Richard Lafayette, MD

HCPLive

In the wake of Vera Therapeutics announcing positive 72-week data from the phase 2b ORIGIN trial, we sat down with lead investigator Richard Lafayette, MD, to learn more about how he interprets the latest data from the atacicept program in IgA nephropathy.

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Cold weather = worse angina symptoms!

Heart Sisters

If you live with heart disease, it’s important to know the surprising effects of COLD TEMPERATURES on your heart health.

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'Heart-on-a-chip' to test chemotherapies and other cancer drugs for heart toxicity

Medical Xpress - Cardiology

Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional "heart-on-a-chip" to evaluate drug safety. In a study published in the journal Lab on a Chip, they show that the heart-on-a-chip, created using stem cells, accurately predicts the effects of drugs on human heart cells.

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Breakthrough Research Identifies Predictors of Venous Thromboembolism after Pulmonary Resection for Lung Cancer

DAIC

milla1cf Mon, 01/29/2024 - 14:26 January 29, 2024 — In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE)—a condition that develops when a blood clot forms in a vein—which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).

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Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus

Cardiovascular Diabetology

Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index.

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Reflecting on the 1964 Surgeon General Report with Viet Le, DMSc, PA-C

HCPLive

In recognition of 60 years since the historic contribution to modern understanding of the harmful effects of cigarette smoking, Albert Rizzo, MD, meets with the preventive cardiology expert to discuss the myriad of cascading effects delivered by the 1964 report.

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Impact of untreated CAD on TAVR outcomes

Cardiology Update

The optimal management of concomitant chronic obstructive coronary artery disease (CAD) in transcatheter aortic valve replacement (TAVR) recipients remains a debated topic. While some advocate for pre-TAVR percutaneous coronary intervention, others adopt an expectant approach. In a recent study published in the European Heart Journal, researchers investigated the influence of varying degrees and extent of untreated chronic obstructive CAD on TAVR outcomes and longer-term results.

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Active components of ginkgo biloba may improve early cognitive recovery after stroke

Science Daily - Heart Disease

Adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) -- a combination of biologically active components of ginkgo biloba -- after an ischemic (clot-caused) stroke had better cognitive recovery at 14 days and 90 days.

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Active components of ginkgo biloba may improve early cognitive recovery after stroke

American Heart News - Stroke News

Research Highlights: In a study conducted in China, adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) — a combination of biologically active components of ginkgo biloba — after an ischemic (clot-caused).

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Women With Alcohol-Related Liver Disease Face Greater Risk of Mortality Than Men

HCPLive

Although there was a greater prevalence of ALD and MetALD among male study participants, females had a greater risk of mortality from both SLD phenotypes, highlighting a potentially greater impact of alcohol consumption on women with liver disease than men.

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First Transcatheter Tricuspid Regurgitation Treatment Approved

Med Page Today

(MedPage Today) -- The FDA approved the Evoque tricuspid valve replacement system as the first transcatheter treatment for tricuspid regurgitation (TR), Edwards Lifesciences announced. Evoque gained an indication for severe TR that is symptomatic.

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New Philips Mini TEE Ultrasound Transducer Helps Improve Cardiac Care for More Patients

DAIC

milla1cf Wed, 01/31/2024 - 17:10 January 31, 2024 — Royal Philips , a global leader in health technology, announced that its latest TEE transducer, designed to serve more patients with improved overall comfort, has received FDA 510(k) clearance. Cardiovascular ultrasound has played a key role in the evolution of early diagnosis of structural heart disease, led by a technology pioneered by Philips: the ‘transesophageal echocardiography’ (TEE) ultrasound transducer.

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Nerve stimulation plus intense rehab may improve arm and hand function after stroke

American Heart News - Stroke News

Research Highlights: Stimulating a nerve that runs between various organs and the brain with intense physical rehabilitation improved arm and hand function in people with stroke. The improved motor function remained at the end of the one-year.

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Laser Flare Photometry Successfully Identifies JIA-Associated Uveitis

HCPLive

Of the 135 laser flare photometry readings to identify uveitis among patients with juvenile idiopathic arthritis, only 3% were characterized as a false positive.

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Exercise training outcomes in patients with chronic heart failure with reduced ejection fraction depend on patient background

Frontiers in Cardiovascular Medicine

Background The aim of this study was to identify significant factors affecting the effectiveness of exercise training using information of the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) study. Methods Background factors influencing the effect of exercise training were comprehensively surveyed for 2,130 patients by multivariable Cox regression analysis with the stepwise variable selection, and only significant factors were selected that were statisti

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Boston Scientific Receives FDA Approval for FARAPULSE Pulsed Field Ablation System

DAIC

The U.S. Food and Drug Administration (FDA), has granted approval to Boston Scientific for its FARAPULSE Pulsed Field Ablation System. A company statement reported that its PFA System is indicated for the isolation of pulmonary veins in the treatment of drug-refractory, recurrent, symptomatic, paroxysmal (i.e., intermittent) atrial fibrillation (AF) and is a unique new alternative to standard-of-care thermal ablation treatment.

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Chest pain, ST Elevation, well-formed Q-waves, and infarction with peak hs troponin I over 1000 ng/L. Is it OMI?

Dr. Smith's ECG Blog

A 60-something male presented stating that he had had chest pain that morning which awoke him from sleep but then resolved after several minutes. He has had similar pain in the past which he attributed to acid reflux. He has a history of untreated hypertension. He is pain free now. His systolic BP was 200. The patient is pain free at the time of this ECG: What do you think?

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Peripheral Apoptotic Lymphocytes May Predict Disease Activity in Juvenile SLE

HCPLive

The percentage of lymphocyte apoptosis in peripheral blood was significantly higher in patients with jSLE when compared with healthy controls.

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Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

Journal of Clinical Investigation - Cardiology

Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis (0NASH) and fibrosis. The mechanisms that prevent NASH and fibrosis in the majority of patients with NAFLD remain unclear. Here, we report that NAD(P)H oxidase 4 (NOX4) and nuclear factor erythroid 2–related factor 2 (NFE2L2) were elevated in hepatocytes early in disease progression to prevent NASH and fibrosis.

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W. L. Gore Receives FDA Approval for Lower Profile Gore Viabahn VBX Balloon Expandable Endoprosthesis

DAIC

GORE VIABAHN VBX Balloon Expandable Endoprosthesis milla1cf Wed, 01/31/2024 - 17:04 January 31, 2024 — As part of efforts to continuously improve medical solutions for patients with complex vascular disease, W. L. Gore & Associates, Inc. (Gore) announced recent FDA approval of a lower profile GORE VIABAHN VBX Balloon Expandable Endoprosthesis ( VBX Stent Graft ).

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Health Effects of Extreme Heat, Wildfire Smoke Worse When Combined

Med Page Today

(MedPage Today) -- Extreme heat and wildfire smoke are independently harmful to the human body, but together their impact on cardiovascular and respiratory systems is more dangerous and affects some communities more than others. A study published.

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