Sat.Dec 14, 2024 - Fri.Dec 20, 2024

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New evidence on the relationship between moderate wine consumption and cardiovascular health

Science Daily - Stroke

Light and moderate consumption of wine is associated with a lower risk of cardiovascular complications, according to a multicenter study. The study is based on the analysis of a biomarker of wine intake -- specifically, tartaric acid, present in grapes. It was carried out in 1,232 participants in the PREDIMED project, a major scientific epidemiological study in nutrition on the effects of the Mediterranean diet on cardiovascular health.

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Keeping Your Heart Healthy Through the Holidays and Into the New Year

AMS Cardiology

The magic of the holidays often comes with hidden challenges for our hearts. Rich foods, packed calendars, and holiday pressures can derail even our best health intentions. Yet maintaining heart health doesn’t mean sacrificing the festivities. Simple, mindful choices during the holiday season can protect your cardiovascular health and lay the foundation for a lively year ahead.

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Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction

Frontiers in Cardiovascular Medicine

Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune

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There are more heart attacks on Christmas than any other day of the year

Medical Xpress - Cardiology

We sing about how Christmas brings "tidings of comfort and joy," but the holiday also brings something not so "merry and bright.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Challenging the CHAGASICS Trial

CardiacWire

Exposing the failures of peer review, Dr. Anis Rassi Jr. MD, PhD, recently published his letter to JAMA Cardiology in Sensible Medicine about glaring issues with the CHAGASICS trial. Dr. Rassi was one of the primary authors and designers of CHAGASICS, but resigned his authorship prior to publishing due to concerns about the study. CHAGASICS aimed to uncover if ICDs were more effective than amiodarone therapy for Chagas cardiomyopathy, finding that ICDs did show some benefits but didnt reduce all

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FDA Expands Indication for Impella Heart Pumps for Pediatric Patients

DAIC

Impella 5.5 with SmartAssist tim.hodson Wed, 12/18/2024 - 14:06 Dec. 12, 2024 Physicians have a new treatment option for many of the sickest pediatric patients with heart failure andcardiogenic shock. Johnson & Johnson MedTech has announcedthat the U.S. Food and Drug Administration (FDA) has expanded the indications for the Impella 5.5 with SmartAssist and Impella CP with SmartAssist heart pumps, granting premarket approval (PMA) for use in specific pediatric patients with symptomatic acute deco

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“One + one” is rarely two in biology. The wronged mathematics of high risk pregnancy

Dr. S. Venkatesan MD

Here is a state of the art review article on peripartum cardiomyopathy from NEJM that came out in Jan 2024. It is one of the comprehensive article on the topic. Everyone will relish, and would like to preserve it as well. Click on the image for the PDF of the article.Sharing here purely for the academic purpose with the courtesy and thanks to NEJM group.

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Research suggests coffee may protect against cognitive decline in people with atrial fibrillation

Medical Xpress - Cardiology

Drinking multiple cups of coffee a day may help prevent cognitive decline in people with atrial fibrillation (AFib or AF), according to new research published in the Journal of the American Heart Association.

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Diabetes Dialogue: Celebrating 2024 - The Year of the Continuous Glucose Monitor

HCPLive

In this episode, hosts reflect on the advancement in CGM that reshaped care for diabetes and overall health during 2024.

Diabetes 115
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Bernoulli equation for Doppler pressure gradient

All About Cardiovascular System and Disorders

Bernoulli equation for calculation of pressure gradient by Doppler echocardiography is: A: P=2V 2 B: P=3V 2 C: P=4V 2 D: P=4V 3 Correct answer: C: P=4V 2 Original Bernoulli equation is a complex equation. This is a simplified equation routinely used in Doppler echocardiography for pressure gradient across valves while quantifying severity of stenosis.

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Tirzepatide Officially Off FDA's Shortage List

Med Page Today

(MedPage Today) -- The shortage of the diabetes and obesity injectable tirzepatide (Mounjaro, Zepbound) has been resolved, the FDA announced Thursday. As a result, compounders will have a grace period of 60 to 90 days to wrap up production and.

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Using an AI tool, researchers find poor vascular health accelerates brain aging

Medical Xpress - Cardiology

Using an AI tool, researchers at Karolinska Institutet have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated with an older-looking brain, while healthy lifestyles were linked to brains with a younger appearance.

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Sedentary Behavior Linked to Increased Gout Risk Even Without Hyperuricemia

HCPLive

A study found the association between sedentary behavior and gout remained strong even when adjusting for physical activity.

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The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals

Journal of Clinical Investigation - Cardiology

Aging negatively affects the capacity of muscle stem cells (MuSCs) to regenerate muscle. In this issue of the JCI, Ancel, Michaud, and colleagues used a high-content imaging screen to identify nicotinamide and pyridoxine as promoters of MuSC function. The combination of the two compounds promoted MuSC function in vivo in aged mice and in primary cells isolated from older individuals.

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Atrial fibrillation: A review

Science Daily - Heart Disease

In the U.S., atrial fibrillation (AF), a heart condition that causes an irregular heartbeat in the upper chambers of the heart, affects up to one in three people in their lifetime. Significant complications associated with this condition include ischemic stroke, heart failure, myocardial infarction, chronic kidney disease, dementia and mortality. In a new review article scientists summarize the current evidence regarding the epidemiology, pathophysiology, diagnosis and management of AF.

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Surprising discovery pinpoints when good cholesterol becomes harmful

Medical Xpress - Cardiology

Houston Methodist researchers have discovered that certain components of so-called "good" cholesterolhigh-density lipoproteins (HDL)may be associated with an increased prevalence of cardiovascular disease.

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CagriSema Achieves 22.7% Weight Loss in Phase 3 REDEFINE 1 Trial

HCPLive

CagriSema, a fixed dose of cagrilintide 2.4 mg and semaglutide 2.4 mg, achieved statistically significant weight loss after 68 weeks versus placebo.

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Are Antibiotics Linked to Dementia? New Study Weighs In

Med Page Today

(MedPage Today) -- Antibiotic use didn't raise the risk of dementia in healthy older adults, a prospective study suggested. Over about 5 years of follow-up, antibiotic use was not tied to higher dementia incidence (HR 1.03, 95% CI 0.84-1.25) compared.

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Overactive cells linked to type 2 diabetes

Science Daily - Heart Disease

Researchers studied oxygen treatment as a potential therapy to target specific cells linked to the development of cardiovascular and metabolic disorders like high blood pressure and type 2 diabetes and found no significant improvement in function in patients with type 2 diabetes.

Diabetes 109
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First dual chamber leadless pacemaker implanted in a child

Medical Xpress - Cardiology

UC Davis Director of Pediatric Electrophysiology Dan Cortez has set another world record: He is the first to implant a dual chamber leadless pacemaker in a child. His case report was published this week in the journal Pacing and Clinical Electrophysiology.

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Colchicine Prophylaxis for Gout Flares Linked to Lower Cardiovascular Events

HCPLive

These findings, from an observational study, should be confirmed in a randomized, controlled trial.

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The FDA Hasn't Inspected This Drug Factory After 7 Recalls for the Same Flaw

Med Page Today

(MedPage Today) -- ProPublica is a Pulitzer Prize-winning investigative newsroom. Sign up for The Big Story newsletter to receive stories like this one in your inbox. The drug potassium chloride has been on the market for decades, widely prescribed.

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First dual chamber leadless pacemaker implanted in a child

Science Daily - Heart Disease

Pediatric cardiologists have implanted a dual chamber leadless pacemaker in a child.

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Clopidogrel edges out aspirin in heart procedure recovery

Medical Xpress - Cardiology

Researchers at 37 sites in South Korea have found patients taking clopidogrel after percutaneous coronary intervention (PCI) experienced lower rates of both thrombotic and bleeding events than those taking aspirin. Clopidogrel's benefits remained consistent regardless of high bleeding risk (HBR) or complex PCI.

Research 102
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Olezarsen Earns First-Ever FDA Approval for Familial Chylomicronemia Syndrome

HCPLive

Olezarsen ushers in a new era of care as the first therapy to receive FDA approval for adults with familial chylomicronemia syndrome as an adjunct to diet.

Diet 111
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Newer Diabetes Drugs Still Under-Prescribed in High-Risk Patients

Med Page Today

(MedPage Today) -- NEW ORLEANS -- Patients at a community health center who had type 2 diabetes and a high risk of atherosclerotic cardiovascular disease (ASCVD) were under-prescribed guideline-recommended treatment with sodium-glucose cotransporter.

Diabetes 101
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Scientists make surprising discovery pinpointing when good cholesterol becomes harmful

Science Daily - Heart Disease

Researchers have discovered that certain components of so-called 'good' cholesterol -- high-density lipoproteins (HDL) -- may be associated with an increased prevalence of cardiovascular disease.

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Risk for cardiovascular conditions increased with anorexia nervosa diagnosis

Medical Xpress - Cardiology

Patients with an anorexia nervosa (AN) diagnosis have an increased risk for cardiovascular conditions, according to a study published online Dec. 19 in JAMA Network Open.

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Brexpiprazole with Sertraline Significantly Reduces PTSD Symptoms in 10 Days

HCPLive

A phase 3 trial shows promising data for brexpiprazole with sertraline for PTSD symptoms ahead of the supplemental new drug applications PDUFA date in February 2024.

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SGLT2 inhibition and adipose tissue metabolism: current outlook and perspectives

Cardiovascular Diabetology

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have emerged as important agents for the treatment of type 2 diabetes mellitus (T2DM). SGLT2 inhibitors have been associated with improved cardiovascular out.

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Cardiovascular Protection Tracks With Wine Intake, Now Provable With Urinary Marker

Med Page Today

(MedPage Today) -- Moderate wine consumption maintained its association with cardiovascular benefit when self-reports were taken out of the equation, the large PREDIMED trial showed. Using urinary tartaric acid as an objective biomarker measuring.

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Traffic noise and poverty create a dangerous cocktail for heart health

Medical Xpress - Cardiology

A new study by the German Center for Cardiovascular Research (DZHK) shows that people on low incomes who are also exposed to high levels of traffic noise have a significantly increased risk of serious cardiovascular disease. The findings highlight the need to tackle social inequalities and environmental pollution together to improve the health of disadvantaged populations.

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Christine Frissora, MD: Vibrant System’s Role in Chronic Idiopathic Constipation Care

HCPLive

Frissora reviews findings from a cost-effectiveness analysis comparing the Vibrant System to linaclotide for CIC management.

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The Grinch’s Guide to Women’s Heart Attacks (with apologies to Dr. Seuss)

Heart Sisters

"Your tests all look fine!" (No one quite knows the reason). You're probably just feeling stressed by the season!

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Woman Dialysis-Free After Receiving Gene-Edited Pig Kidney

Med Page Today

(MedPage Today) -- A 53-year-old woman is free from dialysis after receiving a gene-edited pig kidney transplant at NYU Langone Health, doctors announced on Tuesday. The 7-hour surgery was performed on November 25, marking the third time that.

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Coughing won't save you if you're having a heart attack, despite what people claim on social media

Medical Xpress - Cardiology

A recent trend on social media has revived a curious technique from the late 1970s called cough CPR. A post claims that this method can help people, if they are alone, to survive a heart attack by coughing rhythmically to keep their heart beating. The idea is striking and dramatic, often framed as a life-saving hack, but it's not without controversy.