Sat.Aug 10, 2024 - Fri.Aug 16, 2024

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ECG Blog #443 — A 40s Man with CP and Dyspnea

Ken Grauer, MD

The ECG in Figure-1 was obtained from a man in his 40s — who presented to the ED ( E mergency D epartment ) because of CP ( C hest P ain ) and shortness of breath. QUESTIONS: In view of the above history — How would YOU interpret the ECG in Figure-1 ? Based on the history and the patient's initial ECG — the cath lab was activated. Do you agree? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Shingles Tied to Long-Term Cognitive Changes

Med Page Today

(MedPage Today) -- Herpes zoster (shingles) was tied to an elevated risk of subjective cognitive decline, an analysis of 150,000 U.S. healthcare professionals showed. "In three large independent cohorts, herpes zoster was associated with an approximately.

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Say 'aah' and get a diagnosis on the spot: is this the future of health?

Science Daily - Stroke

A computer algorithm has achieved a 98% accuracy in predicting different diseases by analyzing the color of the human tongue. The proposed imaging system can diagnose diabetes, stroke, anemia, asthma, liver and gallbladder conditions, COVID-19, and a range of vascular and gastrointestinal issues, according to new research.

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Back-to-School Asthma and Lung Health with Juanita Mora, MD and S. Christy Sadreameli, MD

HCPLive

Mora and Sadreameli join Lungcast to provide a back-to-school health blueprint, including topics like rescue inhalers, vaccination, vaping and air quality.

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Gene-related metabolic dysfunction may be driving heart arrhythmia

Science Daily - Heart Disease

Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, according to a new article.

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Medicare Unveils First 10 Negotiated Drug Prices

Med Page Today

(MedPage Today) -- Sitagliptin (Januvia) saw the greatest drop in price among the list of 10 drugs whose new prices were announced Thursday under Medicare's drug price negotiation program. The price negotiation program was passed in 2022 as part.

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Detecting heart stress using NT-proBNP in patients with type 2 diabetes mellitus and hypertension or high-normal blood pressure: a cross-sectional multicentric study

Cardiovascular Diabetology

We evaluated the prevalence of “heart stress” (HS) based on NT-proBNP cut-points proposed by the 2023 Consensus of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in asymptomati.

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Women’s cardiac care: back then, right now and into our future

Heart Sisters

The American Heart Association's recent overview of women's cardiac care feels like an emotional roller coaster ride - from despair to anger and then maybe - just maybe - even hope for our future.

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Dementia Risk Dropped With Anti-Inflammatory Diet for Certain Patients

Med Page Today

(MedPage Today) -- An anti-inflammatory diet was tied to a lower risk for dementia in people ages 60 and older with cardiometabolic diseases, U.K. Biobank data showed. Among people with cardiometabolic diseases including type 2 diabetes, heart.

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Researchers Find ApoB Test May be More Accurate Measure of Heart Disease Risk

DAIC

Ann Marie Navar, M.D., Ph.D. tim.hodson Thu, 08/15/2024 - 10:32 Aug. 13, 2024 – The traditional lipid panel may not give the full picture of cholesterol-related heart disease risk for many Americans, according to a study led by UT Southwestern Medical Center researchers and published in JAMA Cardiology. There are different types of cholesterol particles that can cause heart disease, including low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), and intermediate-density lipopro

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Diabetes Dialogue: SUMMIT and FINEARTS-HF, with Muthiah Vaduganathan, MD, MPH

HCPLive

In this episode, hosts are joined by Muthiah Vaduganathan, MD, MPH, for a discussion around topline data updates from the SUMMIT and FINEARTS-HF trials.

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60 yo with chest pain: why the abnormal QRS and abnormal repolarization?

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his 60s presented with acute chest pain and normal vital signs. Here is his triage ECG: What do you think? The ECG shows massively hyperacute T waves of LAD OMI, plus WPW. V3-V5 also have the depressed HATW takeoff which qualifies them as the rare de Winter subtype of HATWs. Its hard to measure the STE in I exactly with the moving baseline, but there is almost certainly not enough STE to meet STEMI criteria.

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Well-Being Declines Before Mild Cognitive Impairment

Med Page Today

(MedPage Today) -- Psychological well-being waned in the years before mild cognitive impairment, a study of older adults in the Chicago area showed. Among 910 cognitively normal older adults who were followed for up to 14 years, those who developed.

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Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats

Cardiovascular Diabetology

Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are pred.

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Physical Activity Identified as Critical Factor in Lowering MAFLD Risk

HCPLive

A new study found physical activity held more weight in the link between the joint exposure of sleep duration, metabolic equivalent of task, and Healthy Eating Index -2015 and MAFLD.

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10 hospitals with highest, lowest readmissions for heart failure patients

Becker's Hospital Review - Cardiology

Boise, Idaho-based St. Luke's Regional Medical Center has the lowest readmission rate for heart failure patients, CMS found.

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One in Four Brain Injury Patients Who Appear Unresponsive Respond Covertly

Med Page Today

(MedPage Today) -- Cognitive-motor dissociation -- a phenomenon that occurs when patients who appear unresponsive perform cognitive tasks that can be detected on functional MRI (fMRI) or electroencephalography (EEG) -- occurred in one in four.

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Genetic link between Alzheimer's and heart disease confirmed

Science Daily - Heart Disease

Researchers have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.

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Patient Reported Outcomes Favor Concizumab Prophylaxis in Hemophilia A or B

HCPLive

Analysis of the Phase 3 explorer7 study indicates a preference for concizumab prophylaxis over no prophylaxis in patients with hemophilia A or B with inhibitors.

Outcomes 105
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Researchers confirm genetic link between Alzheimer's and heart disease

Medical Xpress - Cardiology

Researchers at Edith Cowan University's (ECU's) Centre for Precision Health have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.

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'Scared to Death': Nurses, Residents Confront Violence in Dementia Care Facilities

Med Page Today

(MedPage Today) -- Dan Shively had been a bank president who built floats for July Fourth parades in Cody, Wyoming, and adored fly-fishing with his sons. Jeffrey Dowd had been an auto mechanic who ran a dog rescue and hosted a Sunday blues radio.

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Where did the P waves go?

Dr. Smith's ECG Blog

Written by Willy Frick I was reading through ECGs in the queue when I saw the following. What do you think of the rhythm? At first glance there seems to be a lot of variation happening, but by focusing on one part of the ECG at a time we can make sense of it. Ignore the first QRS complex and look at beats 2 through 5. I have labeled them below for ease of reference: We see P waves which are upright in leads I, II, and aVF, and upside down in aVR.

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Assessing PBC Treatment Options, Determining Sequencing

HCPLive

In this video segment, Reau, Trivedi, and Hirschfield discuss the EMA opinion on obeticholic acid and its impact on discussions about second-line therapies amid the influx of new treatment options available for patients.

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Work-related stress may increase the risk of an irregular heart rhythm

Science Daily - Heart Disease

Job strain and effort-reward imbalance at work were associated with a greater chance of developing an abnormal heart rhythm condition, finds a new study.

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Is Medicare's Negotiated Drug Price List Worth Celebrating? Depends on Whom You Ask.

Med Page Today

(MedPage Today) -- Physician and consumer groups expressed positive responses to Medicare's release Thursday of its price list for the first 10 negotiated drugs under its Drug Price Negotiation program, but the pharmaceutical industry was not so.

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Stress and substance use disorders: risk, relapse, and treatment outcomes

Journal of Clinical Investigation - Cardiology

Stress has long been associated with substance misuse and substance use disorders (SUDs). The past two decades have seen a surge in research aimed at understanding the underlying mechanisms driving this association. This Review introduces a multilevel “adaptive stress response” framework, encompassing a stress baseline, acute reaction, and recovery with return-to-homeostasis phase that occurs at varying response times and across domains of analysis.

Outcomes 130
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Early HCV Treatment Discontinuation Does Not Inhibit Sustained Virologic Response

HCPLive

Findings highlight a 78.4% treatment success rate among patients who prematurely discontinued DAAs, reaching 93.5% among those who discontinued after week 4.

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Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve Implantation

JAMA Cardiology

This randomized clinical trial evaluates the safety and efficacy of administration of protamine to reduce bleeding following transcatheter aortic valve implantation vs placebo, selective protamine administration.

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GLP-1 Agonists for Diabetes Tied to Lower Hyperkalemia Rates

Med Page Today

(MedPage Today) -- Hyperkalemia in type 2 diabetes occurred less often with GLP-1 receptor agonists in routine care than dipeptidyl peptidase-4 (DPP-4) inhibitors, a large observational study in Sweden showed. Over a median 3.9-month treatment.

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Better transplantations with 'heart-in-a-box': Study finds method reduces early heart failure risk

Medical Xpress - Cardiology

The risk of early heart failure after heart transplantation is lower if the donor heart is stored in a so-called heart-in-a-box instead of in the usual cooler with ice. This is according to a study by researchers at the University of Gothenburg.

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Glomerular IgM Deposit Intensity Shows Clinical Significance in IgA Nephropathy

HCPLive

Findings suggest increased intensity of IgM deposits in patients with positive IgM deposition may contribute to adverse clinicopathologic presentation and clinical outcomes.

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How Hollywood is perpetuating heart attack misconceptions

Becker's Hospital Review - Cardiology

Study reveals how movies perpetuate misconceptions about heart attacks, with limited representation of women and people of color, potentially impacting public

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FDA to Challenge Food Industry to Take Up New Sodium Targets

Med Page Today

(MedPage Today) -- The food industry can expect new voluntary sodium reduction targets from the FDA for commercially processed, packaged, and prepared foods. As part of its overall initiative to reduce sodium consumption on the population level.

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Study highlights potential for using TMAO—a digestive by-product—to predict heart failure risk

Medical Xpress - Cardiology

New Cleveland Clinic and Tufts University research shows that elevated levels of the gut microbiome trimethylamine N-oxide (TMAO) pathway led to a higher risk of heart failure independent of other risk factors, according to a study of two large National Institutes of Health cohorts. The study was recently published in the journal Circulation: Heart Failure.

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Atopic Dermatitis Linked to Increased Risk of IgA Nephropathy

HCPLive

Findings from the bidirectional 2-sample Mendelian randomization study suggest a strong positive causal association between atopic dermatitis and IgAN.

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Human genetics and epigenetics of alcohol use disorder

Journal of Clinical Investigation - Cardiology

Alcohol use disorder (AUD) is a prominent contributor to global morbidity and mortality. Its complex etiology involves genetics, epigenetics, and environmental factors. We review progress in understanding the genetics and epigenetics of AUD, summarizing the key findings. Advancements in technology over the decades have elevated research from early candidate gene studies to present-day genome-wide scans, unveiling numerous genetic and epigenetic risk factors for AUD.

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What's the Best Way to Help Specialists Succeed? Beef Up Primary Care

Med Page Today

(MedPage Today) -- In today's modern world, where does primary care fit in? Especially at large academic medical centers like ours, the focus across the institution tends to be on secondary, tertiary, and quaternary care. This is the stuff that.

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