Sat.Nov 16, 2024 - Fri.Nov 22, 2024

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Weight-loss drug found to shrink heart muscle in mice and human cells

Medical Xpress - Cardiology

Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study in JACC: Basic to Translational Science. The authors say the research should serve as a "cautionary tale" about possible long-term health effects of these drugs.

Research 142
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The human heart may have a hidden ability to repair itself

Science Daily - Heart Disease

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.

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Instructor Collection ECG: Anterior M.I. and Left Ventricular Hypertrophy

ECG Guru

The Patient: Sixty-year-old man with a complaint of severe substernal chest pain. Denies hx of M.I., but reports feeling short of breath on exertion for about a year. Hx of hypertension, but admits he is non-compliant with his medication. Appears pale and diaphoretic, BP 110/68. The ECG: The rhythm is sinus at 62 bpm. The QRS is slightly wide at 110 ms (.11 seconds), but still within normal limits.

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Over 50% of U.S. Adults Qualify for Ozempic, Wegovy

Med Page Today

(MedPage Today) -- More than half of all adults in the U.S. are eligible for semaglutide (Ozempic, Wegovy, Rybelsus), researchers estimated. Among 25,531 participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to.

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New genetic explanation for heart condition revealed

Medical Xpress - Cardiology

A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single "aberrant" genetic variant, as was previously thought, finds a new study led by researchers at UCL (University College London), Imperial College London and the MRC Laboratory of Medical Sciences.

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Finding a Role for GLP-1 RAs, Incretin Therapies in Heart Failure, with Muthiah Vaduganathan, MD, MPH

HCPLive

Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.

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Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Discovery explains kidney damage caused by blood pressure drugs

Science Daily - Heart Disease

Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.

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The human heart may have a hidden ability to repair itself

Medical Xpress - Cardiology

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.

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Recent Advances Have Improved Prognosis in ATTR-CM Patients, with Ahmad Masri, MD, MS

HCPLive

Ahmad Masri, MD, MS, discusses a study from AHA 2024 detailing changing risk profiles and outcomes in trials among patients with ATTR-CM.

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Electronic Nudges Improved Flu Shot Uptake in Patients With Acute MI History

Med Page Today

(MedPage Today) -- CHICAGO -- Electronic nudges increased uptake of flu vaccines among patients with a history of acute myocardial infarction (MI), results from three Danish randomized trials showed. Among over 2 million patients, a letter explaining.

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In a small international trial, novel oral medication muvalaplin lowered Lp(a)

American Heart News - Heart News

Research Highlights: The oral medication muvalaplin may safely lower high levels of lipoprotein(a), also known as Lp(a), an independent, inherited risk factor for cardiovascular disease. Muvalaplin is a small molecule inhibitor that prevents the.

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Cardiology collaboration advances machine learning predictions for AFib after stroke

Medical Xpress - Cardiology

Researchers at Penn State are using machine learning and existing electrocardiogram (ECG) data to help doctors make more accurate predictions. A team of artificial intelligence engineers, in collaboration with a team of physicians from Penn State Heart and Vascular Institute, is working to develop novel algorithms for point-of-care, in-house use and for technology licensing.

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LDL Cholesterol–Lowering Strategy in ASCVD

JAMA Cardiology

This systematic review and individual patient data meta-analysis investigates the association of an alternative low-density lipoprotein (LDL) strategy with differences in long-term efficacy and safety in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a high-intensity statin strategy.

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GLP-1 Use Prior to Surgery: Analyzing the Updated Guidance

Med Page Today

(MedPage Today) -- Since the modern practice of anesthesia has evolved, providers have been concerned about pulmonary aspiration -- when gastric contents enter the lung, resulting in severe complications including pneumonitis, and aspiration.

Pulmonary 105
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New genetic explanation for heart condition revealed

Science Daily - Heart Disease

A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single 'aberrant' genetic variant, as was previously thought, finds a new study.

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Study Highlights Wound Closure Techniques Following Wide Excision for HS

HCPLive

This meta-analysis showed that both secondary closure techniques substantially reduce the risk of hidradenitis suppurativa recurrence compared to primary direct closure.

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Data brief: Prevalence of high total cholesterol 11.3% in US adults from Aug. 2021–Aug. 2023

Medical Xpress - Cardiology

The prevalence of high total cholesterol was 11.3% among U.S. adults from August 2021 to August 2023, according to a November data brief published by the National Center for Health Statistics.

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Tirzepatide Officially Puts GLP-1 Meds on the Map for Obesity-Related Heart Failure

Med Page Today

(MedPage Today) -- CHICAGO -- A long-acting GIP/GLP-1 receptor agonist conferred significant clinical benefit for people with obesity and accompanying heart failure with preserved ejection fraction (HFpEF), according to the SUMMIT trial. Incident.

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Tirzepatide lowered risk of worsening heart failure and CVD death for obese adults

American Heart News - Heart News

Research Highlights: In an international trial of 713 adults in nine countries including the U.S. called SUMMIT, participants with heart failure with preserved ejection fraction (HFpEF) and obesity taking tirzepatide for an average of 2 years had.

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Medical Ethics Unpacked: Ethical Foundations and Background of Euthanasia & Medically-Assisted Suicide

HCPLive

In part 1 of this 2-part discussion, hosts explore the ethical foundation and background of euthanasia and medically-assisted suicide.

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Anthos Presents New Analysis from P2 AZALEA-TIMI 71 Study

DAIC

tim.hodson Mon, 11/18/2024 - 10:55 Nov. 16, 2024 Anthos Therapeutics, Inc.recently presented new data at the American Heart Association (AHA) Scientific Sessions from its AZALEA-TIMI 71 study that demonstrated the novel factor XI inhibitor abelacimab led to consistent and substantial reductions in bleeding for patients on or off antiplatelet (APT) therapy, as compared to rivaroxaban.

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Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction

JAMA Cardiology

This prespecified secondary analysis of a randomized clinical trial examines the efficacy and safety of finerenone in women and men with heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction.

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Ablation may be better than medication for those with dangerous heartbeat after heart attack

American Heart News - Heart News

Research Highlights: A new, multicenter study demonstrated that ablation treatment may be a better first option than medication for many heart attack survivors who develop abnormal electrical short circuits in their heart, which are episodes of.

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AASM Updates Clinical Guidelines for Restless Legs Syndrome

HCPLive

Following the publication of the new RLS recommendations, HCPLive spoke with John Winkelman, MD, PhD, chair of the AASM committee that revised the guidelines.

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Mapping the intersection of sudden cardiac death and COVID-19: a comprehensive bibliometric analysis (2020–2024)

Frontiers in Cardiovascular Medicine

IntroductionA direct causal link between Sudden Cardiac Death (SCD) and COVID-19 is unproven, although current data suggest a plausible association.AimThis study aims to map and analyze the intersection of research on sudden cardiac death and COVID-19 through a comprehensive bibliometric analysis.MethodologyThis study searched the literature by applying the keywords “COVID-19” AND “Sudden Cardiac Death (SCD)”.

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Standing at work can be detrimental to blood pressure

Science Daily - Heart Disease

A new study found that prolonged standing at work had a negative impact on the research participants' 24-hour blood pressure. In contrast, spending more time sitting at work was associated with better blood pressure. The study suggests that activity behavior during working hours may be more relevant to 24-hour blood pressure than recreational physical activity.

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Giving pharmacists feedback improved care for veterans with heart failure

American Heart News - Heart News

Research Highlights: Pharmacists in the Veterans Health Administration System who received feedback on their patients' heart failure medication rates, along with educational tools and targeted information, had a significant increase in the frequency.

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A woman in her 40s with acute chest pain and shortness of breath

Dr. Smith's ECG Blog

Written by Pendell Meyers A woman in her 40s presented with acute chest pain and shortness of breath. Vitals were within normal limits. Here is her triage ECG: What do you think? Smith : This is classic for pulmonary embolism (PE). There are 2 key points to making this diagnosis on the ECG: 1) There is T-wave inversion which you might think is due to Wellens' waves, but the patient has active symptoms, so it is not Wellens' sydrome 2) The T-wave inversion in V1-V4 is accompanied by T-wave invers

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Lack of Clinical Benefit of Andexanet Flummoxes FDA Panel

Med Page Today

(MedPage Today) -- FDA advisors pushed for nuance in discussing whether andexanet alfa (Andexxa) should gain full approval, citing uncertainties about which dose and in which patients it could be best used to stop bleeding. Members of the Cellular.

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Children with IBD Respond Well to the Pfizer COVID-19 Vaccination, with Arthur Kastl, MD

HCPLive

HCPLive spoke with Kastl at NASPGHAN about the team’s study on the immune response to the COVID-19 vaccination among children with IBD.

COVID-19 102
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Spironolactone, a blood pressure medication, may help reduce risk of new heart failure

American Heart News - Heart News

Research Highlights: The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart attack or stroke. More research is needed to further.

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Blood pressure variability linked to accelerated vision loss in glaucoma

Medical Xpress - Cardiology

University of California, San Diego-led research suggests that long-term variability in blood pressure is associated with accelerated worsening of peripheral vision due to the progression of glaucoma.

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Reused Pacemakers Good as New in Early Safety Data

Med Page Today

(MedPage Today) -- CHICAGO -- Secondhand permanent pacemaker use in poorer countries, following thorough cleaning and repackaging, has not resulted in patient harm so far, according to the My Heart Your Heart trialists. In patients who could.

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Obesity-Related Heart Disease Deaths Rose Roughly 180% Since 1999

HCPLive

Obesity-related ischemic heart disease deaths rose from 1999 to 2020, particularly in middle-aged men and Black adults, per CDC WONDER data.

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Email reminders improved flu shot rates in Denmark, notably among heart attack survivors

American Heart News - Heart News

Research Highlights: An electronic message to "nudge" patients to get a flu vaccine highlighting the cardiovascular benefits of flu shots improved vaccination rates among more than two million adults in three clinical trials in Denmark. The research.

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Weight-loss drug reduces risk of early death for patients with heart failure, trial finds

Science Daily - Heart Disease

Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with obesity and heart failure with preserved pump function, new research reveals.