Sat.Nov 23, 2024 - Fri.Nov 29, 2024

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ECG Blog #457 — Is Anything Conducting?

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that that it was from an acutely ill patient on a ventilator, who was being evaluated for bradycardia. His providers thought this rhythm was complete AV block. QUESTIONS: How would you interpret the ECG in Figure-1 ? Is the rhythm complete AV block? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Irregular sleep-wake cycle linked to heightened risk of major cardiovascular events

Medical Xpress - Cardiology

An irregular sleep-wake cycle is associated with a heightened risk of major cardiovascular events, such as heart attack and stroke, even for those who clock up the recommended nightly hours of shut-eye, finds research published online in the Journal of Epidemiology & Community Health.

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World's most common heart valve disease linked to insulin resistance in large national study

Science Daily - Heart Disease

A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease -- aortic stenosis (AS).

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Schizophrenia with Violence Linked to Reduced Left Frontal Gray Matter, Higher TSH

HCPLive

A study found patients with schizophrenia exhibiting violence, vs. those who don’t, have less gray matter volume in the frontal lobe and greater thyroid-stimulating hormone levels.

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What makes a T-wave Hyperacute? And: 30 Examples of Hyperacute T-waves, 10 in each of 3 myocardial territories.

Dr. Smith's ECG Blog

Pendell and I and the geniuses at Powerful Medical (Producers of the PMCardio Queen of Hearts OMI AI app ) are working on an objective, mathematical definition of hyperacute T-waves , based on real OMI outcomes and hyperacute T-wave annotation that has excellent interrater agreement (between me and Pendell), and it will end up being a logistic regression using these 3 variables: 1) area under the curve (AUC) relative to the QRS size 2) increased symmetry , as defined by time from T-wave onset to

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Men at high risk of cardiovascular disease face brain health decline 10 years earlier than women, study finds

Medical Xpress - Cardiology

Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier—from their mid 50s to mid 70s—than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry.

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Popular diabetes and obesity drugs also protect kidneys, study shows

Science Daily - Heart Disease

The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.

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More Trending

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Can Antipsychotics Increase Mortality Risk? A New Study Shows It Might

HCPLive

A study showed high-dose antipsychotics and benzodiazepines were linked to an increased mortality risk for those with schizophrenia. High-dose antidepressants lowered the risk.

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Gene-screening method identifies cause of heart cell damage from chemotherapy

Medical Xpress - Cardiology

Using a gene-screening method they created, Stanford Medicine researchers may have discovered why an effective chemotherapy damages heart cells—and they have identified a drug that could keep the heart cells beating.

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The link between sleep and blood pressure: New research sheds light on gender differences

Science Daily - Heart Disease

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders -- strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes. Sleep differences have been reported for some time in men and women, but it is not well known whether the characteristics of sleep serve different functions in one gender over the other, especially as it relates to the heart.

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ASCVD Mortality Linked to Specific Air Pollution Sources

Med Page Today

(MedPage Today) -- The relationship between air pollution and cardiovascular harm was supported by another study, this time down to the level of specific types of pollution that appeared to have varying effects according to geographical region.

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Alexei Grom, MD: Exploring Safer Treatment Options for Refractory Macrophage Activation Syndrome

HCPLive

Emapalumab may improve outcomes in patients with MAS whose disease didn’t respond to steroid therapy and mitigate the need for more toxic therapies.

Outcomes 118
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Review highlights racial disparities in sudden cardiac arrest and death among athletes

Medical Xpress - Cardiology

A recent major review of data published by The Lancet and led by Emory sports cardiologist Jonathan Kim, MD, shows that Black athletes are approximately five times more likely to experience sudden cardiac arrest (SCA) and sudden cardiac death (SCD) compared to white athletes, despite some evidence of a decline in rates of SCD overall. SCA and SCD have historically been a leading cause of mortality among athletes, particularly those involved in high-intensity sports.

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Top hospitals for cardiac care: Healthgrades

Becker's Hospital Review - Cardiology

Healthgrades published its 2025 Specialty Excellence Awards recipients Oct. 22. Of those, 97 hospitals were recognized for delivering superior clinical outcomes in cardiac care for heart bypass surgery, coronary interventional procedures, heart attack treatment, heart failure treatment and heart valve surgery.

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Coronary Angiography Guide by Willy Frick -- Everything you ever wanted to know about the Cath Lab

Dr. Smith's ECG Blog

Introductory Angiography Guide To find the guide later, go to the banner at the top of the blog: This blog is dedicated to improving understanding of ECGs in the context of emergency medicine. A substantial proportion of cases discussed include diagnostic angiography. Attaining expertise in angiography requires dedication and practice. What follows is an introduction to angiography -- a guide meant for people with no prior experience interpreting angiograms.

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Muvalaplin Aces Phase 2 Lp(a) Test

CardiacWire

Impressive results from the Phase 2 KRAKEN trial presented at the AHA 2024 Scientific Sessions showed that Eli Lilly’s muvalaplin greatly reduces Lp(a) blood levels, adding an attractive oral option to its Lp(a) pipeline. High Lp(a) is an inherited CVD risk factor that impacts one out of every five people and currently has no approved drug therapies.

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Impact of IgAN on Quality of Life

HCPLive

Panelists discuss how IgA nephropathy affects patients’ quality of life, addressing both the physical symptoms and the emotional challenges associated with the condition.

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The link between sleep and blood pressure: New research sheds light on gender differences

Medical Xpress - Cardiology

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders—strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes. Sleep differences have been reported for some time in men and women, but it is not well known whether the characteristics of sleep serve different functions in one gender over the other, especially as it relates to the heart.

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Risk of heart problems persists years after COVID infection: 4 study findings

Becker's Hospital Review - Cardiology

A recent study using data from the UK BioBank highlighted the extended risk of major adverse cardiac events in individuals who have recovered from COVID-19.

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Hunting & Heart Attacks; Cardiologist's Whistleblower Suit; Algorithm Predicts Death

Med Page Today

(MedPage Today) -- The American Heart Association said that hunters should be advised that physical exertion, colder temperatures, and the thrill of the hunt can put them at risk for heart attack or stroke. Merck announced positive topline results.

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Vitamin D Deficiency More Common in Lupus Nephritis Than Lupus Without Kidney Disease

HCPLive

Hypovitaminosis D was more prevalent in patients with lupus nephritis compared to patients with systemic lupus erythematosus without kidney disease.

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Certain hormone replacement therapy tablets linked to increased heart disease and blood clot risk

Medical Xpress - Cardiology

Certain hormone replacement therapy (HRT) tablets containing both estrogen and progestogen are associated with a higher risk of heart disease and rare but serious blood clots known as venous thromboembolism (VTE) in women around the age of menopause, finds a study from Sweden published in The BMJ today.

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Emory hospital 1st in US to transplant magnet heart pump

Becker's Hospital Review - Cardiology

An Atlanta-based Emory University Hospital team became the first in the U.S. to perform a surgical implantation of magnetically levitated ventricular assist device.

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Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity

JAMA Cardiology

This study compares clopidogrel vs aspirin monotherapy in patients with high bleeding risk and/or percutaneous coronary intervention complexity.

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Early Detection of CKD in Stages 2 and 3

HCPLive

Panelists discuss how early detection of chronic kidney disease (CKD) in stages 2 and 3 can improve patient outcomes across various specialties, including nephrology, cardiology, and primary care.

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World's most common heart valve disease linked to insulin resistance

Medical Xpress - Cardiology

A large population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease—aortic stenosis (AS).

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Different menopausal hormone treatments pose different risks

Science Daily - Heart Disease

Researchers have analysed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack. The study, which involved around one million women aged between 50 and 58, is the largest and most comprehensive study of currently prescribed hormonal substances in the world. The results show that the risks differ depending on the active substance and how the medicine is taken.

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Many Drinkers Cut Back After Starting Obesity Meds, Study Finds

Med Page Today

(MedPage Today) -- Nearly half of participants in a weight-loss program who consumed alcohol at baseline began drinking less after adding an obesity drug into their weight-management regimen, a cohort study indicated. Among the 7,491 participants.

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LUNA, OPTIC Data Support Long-Term Benefit of Ixo-Vec for Wet AMD

HCPLive

New 52-week LUNA and 4-year OPTIC data demonstrate Ixo-vec’s potential to reduce injection burden, maintain vision, and achieve lifelong benefits for wet AMD.

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Research shows death rates linked to obesity-related heart disease are up, especially among men

Medical Xpress - Cardiology

The rate of deaths from ischemic heart disease related to obesity nearly tripled in the U.S. over a two-decade span, according to new research. The rate for men more than tripled.

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Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes

Cardiovascular Diabetology

Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophys.

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Recent MI at another facility. Now back in the ER with chest pain

Dr. Smith's ECG Blog

Written by Willy Frick A young woman with a history of paroxysmal nocturnal hemoglobinuria presented with acute substernal chest pain. Five days prior, she had a similar presentation to a different hospital. She underwent coronary angiography which showed thrombotic occlusion of an RPL branch s/p aspiration thrombectomy. The report describes heavy plaque in the proximal RCA by IVUS, but no lesions in the previously occluded RPL branch and no stent was deployed.

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Meta-Analysis Supports Potential Use of Ketamine for PTSD, OCD

HCPLive

A recent study suggests ketamine can significantly improve symptoms of PTSD and OCD—but this is based on a review of an insufficient number of randomized controlled trials.

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Researchers reprogram skin cells to create human-compatible pig heart valve

Medical Xpress - Cardiology

Human skin cells have been reprogrammed into heart valve cells and then used to successfully transplant a pig heart valve into a rodent, led by the research of a Northeastern University professor.

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Managing Drug-Drug Interactions with Mavacamten: a Focus on Combined Use of Anti-Arrhythmic Drugs and Anticoagulants

HeartRhythm

Mavacamten is a selective, allosteric, and reversible cardiac myosin inhibitor, representing the first disease-specific treatment for obstructive hypertrophic cardiomyopathy (HCM) that targets the core pathophysiological mechanism of this condition. Clinical evidence supports its efficacy in improving symptoms, cardiac function and remodeling, thereby supplementing established treatment regimes.

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Healing the gut can reduce long-term impact of stroke

Science Daily - Stroke

Healing the gut may be the key to improving long-term recovery in stroke patients, scientists have found. The latest of multiple studies highlights the potential of this novel avenue of treatment, which takes advantage of the link between the brain and digestive system to curb cognitive impairment and other lingering impacts of a stroke or brain trauma.

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FDA Accepts Alnylam’s sNDA for Vutrisiran for ATTR-CM

HCPLive

The FDA set the Prescription Drug User Fee Act (PDUFA) date for the investigational RNAi therapeutic as March 23, 2025.

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