Ken Grauer, MD

JANUARY 5, 2024

How would YOU interpret the tracing in Figure-1 — that was sent to me without additional information? QUESTIONS: What is the rhythm? Is there AV dissociation? If so — WHY? Clinically — HOW would you approach interpretation of this tracing in optimal time -efficient fashion? Figure-1: The initial ECG in today's case. KEY Clinical Point: If I was the medical provider charged with the care of the patient whose ECG is shown in Figure-1 — I would approach this tracing in the following sequential stag

Blog 178

Blog Chest Pain Arrhythmia 178

Nature Reviews - Cardiology

JANUARY 1, 2024

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00962-3 Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome. In this Review, Fedorowski and colleagues define the major forms of CVAD (including postural orthostatic tachycardia syndrome), and discuss the aetiology, diagnosis and management of post-COVID-19 syndrome-associated CVAD.

COVID-19 145

COVID-19 Tachycardia 145

Medical Xpress - Cardiology

JANUARY 3, 2024

Preeclampsia and other hypertensive disorders of pregnancy—which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy—carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.

Hypertension 125

Hypertension Circulation Blood Pressure Research 125

ECG Weekly Workout

DECEMBER 31, 2023

HPI: A 50-year-old man decides to get “his life in order” for the new year. He quits smoking, decides to eat healthier and exercise more, and to be more compliant with his blood pressure medications. A week into the new year he wakes up feeling weak and achy with nausea and vomiting. He is lightheaded when sitting or standing and has trouble getting out of bed.

Blood Pressure 130

Blood Pressure CME Exercise Bradycardia 130

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our study, we used single-cell expression and chromatin accessibility tools to characterize the mineralocorticoid target genes and cell types. We demonstrated that mineralocorticoid effects were established through open chromatin and target gene expression, primarily in principal and connecting tubule cells and, to a lesser extent, in segments of the distal convoluted tubule cells.

Kidney Disease 132

Kidney Disease Blood Pressure Hypertension 132

Nature Reviews - Cardiology

JANUARY 3, 2024

Nature Reviews Cardiology, Published online: 04 January 2024; doi:10.1038/s41569-023-00979-8 In this Review, Sarraju and Nissen summarize the clinical trial evidence for coronary atherosclerotic plaque stabilization and regression with plasma LDL-cholesterol-lowering therapy and other treatments. Invasive and non-invasive imaging modalities used to assess plaque burden and composition are discussed.

Plaque 139

Plaque Cholesterol 139

Med Page Today

JANUARY 1, 2024

(MedPage Today) -- In January, we reported on Damar Hamlin's collapse during a televised football game. In this report, we follow up on the resulting public interest on sudden cardiac arrest that made Hamlin the most searched person of 2023. During.

Cardiac Arrest 134

Cardiac Arrest 134

HCPLive

JANUARY 3, 2024

Mindfulness-Oriented Recovery Enhancement plus methadone treatment is a promising treatment option for patients with opioid use disorder, having been significantly associated with less return to drug use and methadone treatment dropout, a new study found.

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Nature Reviews - Cardiology

JANUARY 1, 2024

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00958-z In this Review, the authors discuss the latest insights on RNA-binding proteins and RNA biology and appraise them in the context of cardiovascular research, summarizing the progress in our understanding of the involvement of RNA-binding proteins in cardiac biology and disease.

Research 138

Research 138

Med Page Today

JANUARY 5, 2024

(MedPage Today) -- People who had fragmented sleep in their 30s and 40s were more likely to have worse cognition a decade later, longitudinal data showed. Those in the highest versus the lowest tertile of the sleep fragmentation index had over.

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124

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

BACKGROUND Systemic administration of adeno-associated virus (AAV) can trigger life-threatening inflammatory responses, including thrombotic microangiopathy (TMA), acute kidney injury due to atypical hemolytic uremic syndrome–like complement activation, immune-mediated myocardial inflammation, and hepatic toxicity.METHODS We describe the kinetics of immune activation following systemic AAV serotype 9 (AAV9) administration in 38 individuals following 2 distinct prophylactic immunomodulation regim

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Medical Xpress - Cardiology

JANUARY 3, 2024

Findings from a published case series research letter by the Henry Ford Health Structural Heart Disease team show that severe mitral stenosis, due to a build-up of calcium deposits in the mitral valve common in elderly patients, can be safely and successfully treated using Intravascular lithotripsy (IVL)-enabled percutaneous balloon mitral valvuloplasty.

Heart Valves 110

Heart Valves Bicuspid/Mitral Stenosis Heart Disease 110

Physiologically Speaking

JANUARY 5, 2024

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Plaque 114

Plaque Physiology Exercise Cholesterol 114

Med Page Today

JANUARY 5, 2024

(MedPage Today) -- Maternal type 1 diabetes (T1D) emerged as the larger contributor to the child's risk of congenital heart defect (CHD) when considering maternal diabetes and weight status together, a Finnish population-based cohort study found.

Diabetes 126

Diabetes Congenital 126

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture by autophagic machinery remain poorly understood. Here, we identified cyclin-dependent kinase–like 5 (CDKL5), known to function in neurodevelopment, as an essential regulator of virophagy.

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HCPLive

JANUARY 2, 2024

Various factors related to demographics, psychosocial behavior variables, and clinical characteristics were linked to health-related quality of life in patients with gout.

Quality of Life 116

Quality of Life 116

Cardiology Update

JANUARY 2, 2024

As we step into 2024, the field of cardiology continues to offer exciting opportunities for knowledge exchange and networking at in-person conferences. Here is a preview of the upcoming cardiology conferences planned for 2024. 1. ESC Acute CardioVascular Care (ACVC) Date: March 8-10, 2024 Location: Athens, Greece Overview: ACVC offers the latest science, networking, and simulation workshops for managing acute and critical cardiovascular conditions.

Heart Failure 111

Heart Failure Atherosclerosis Cardiovascular Imaging Non-Invasive Cardiology 111

Med Page Today

JANUARY 3, 2024

(MedPage Today) -- It's the season for resolutions -- and the annual "Best Diets" rankings from U.S. News & World Report. For 2024, the Mediterranean diet once again took the top spot for best overall diet. With its emphasis on intake of.

Diet 116

Diet 116

Becker's Hospital Review - Cardiology

JANUARY 3, 2024

Dallas-based UT Southwestern Medical Center researchers found a two-step screening protocol combining clinical risk assessment with biomarker testing that can identify which patients with Type 2 diabetes need medication to prevent heart failure.

Heart Failure 110

Heart Failure Diabetes Biomarkers Research 110

HCPLive

JANUARY 4, 2024

BLA submission was based on data from phase 3 clinical trials in which DMB-3115 showed no clinically meaningful differences compared with the reference product for the treatment of plaque psoriasis.

Plaque 111

Plaque 111

Dr. Smith's ECG Blog

JANUARY 5, 2024

Written by Willy Frick A 46 year old man with a history of type 2 diabetes mellitus presented to urgent care with complaint of "chest burning." The documentation does not describe any additional details of the history. The following ECG was obtained. ECG 1 What do you think? The ECG shows sinus bradycardia but is otherwise normal. There is TWI in lead III, but this can be seen in normal ECGs.

Angina 106

Angina Plaque Document Stent 106

Med Page Today

JANUARY 2, 2024

(MedPage Today) -- The newborn that received the world's first partial heart transplant in 2022 continued to do well a year later, according to a case report from the transplant team. Born with type A2 persistent truncus arteriosus and irreparable.

Heart Transplant 116

Heart Transplant Transplant Heart Valves 116

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a restriction on cytotoxic T cell immunity if DCs are not present in sufficient numbers in the tumor and draining lymph nodes to take up and present relevant cancer antigens.

Cancer 111

Cancer 111

HCPLive

JANUARY 4, 2024

In a new study, hearing loss was significantly associated with a 7% higher risk of dementia, while hearing aids were shown to reduce such risks.

Dementia 122

Dementia 122

DAIC

JANUARY 5, 2024

As the Diagnostic and Interventional Cardiology (DAIC) team welcomes in the New Year, we also have taken a few moments to reflect back on the Top 10 most read content from 2023. 1. A Dietary Supplement Leads to Remarkable Regression in Atherosclerotic Lesions 2. Medtronic Creates History with FDA Approval of its Novel PulseSelect Pulsed Field Ablation System to Treat Atrial Fibrillation 3.

Atrial Fibrillation 105

Atrial Fibrillation Aortic valve Cardiothoracic Interventional Cardiology 105

Medical Xpress - Cardiology

JANUARY 3, 2024

The world's first partial heart transplant has achieved what researchers have spent more than a year hoping for—functioning valves and arteries that grow along with the young patient, as hypothesized by the pioneering team behind the procedure at Duke Health.

Heart Transplant 105

Heart Transplant Transplant Research 105

Med Page Today

JANUARY 1, 2024

(MedPage Today) -- Mortality rates were high among patients with high-risk pulmonary embolism (PE), with the worst outcomes in those with hemodynamic collapse, according to a retrospective analysis of the Pulmonary Embolism Response Team (PERT.

Embolism 119

Embolism Pulmonary Hospital Outcomes 119

HCPLive

DECEMBER 31, 2023

A systematic review and meta-analysis suggests the dual pathway-targeting faricimab provides some greater benefit in outcomes like CST at fewer injections and without compromise of safety to anti-VEGF monotherapies.

Outcomes 108

Outcomes 108

DAIC

JANUARY 4, 2024

Credit: American Association of Critical-Care Nurses milla1cf Thu, 01/04/2024 - 11:00 January 4, 2024 — The days of prolonged fasting prior to cardiac catheterization may be numbered, as the body of evidence grows to allow patients to eat before the procedure. Patients undergoing coronary artery catheterization are typically required to take nothing by mouth after midnight prior to their procedure, but there is no evidence to support this long-standing practice.

Diet 105

Diet Critical Care Inpatient RN 105

ECG Cases

JANUARY 2, 2024

Based on a blend of number of listens, feedback from listeners, website visits and personal faves, EM Cases Best of 2023 Top 10. The post EM Cases Best of 2023 Top 10 appeared first on Emergency Medicine Cases.

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Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Several poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved by FDA to treat cancer with BRCA mutations. BRCA mutations are considered to fuel a PARPi killing effect by inducing apoptosis. However, resistance to PARPi is frequently observed in the clinic due to an incomplete understanding on the molecular basis of PARPi function and a lack of good markers, beyond BRCA mutations, to predict response.

Cancer 105

Cancer 105

HCPLive

JANUARY 5, 2024

Patients with lean NAFLD had fewer metabolic comorbidities but maintained similar risk of NASH, cirrhosis, nonliver cancer, and mortality compared to their overweight and obese counterparts.

BMI 105

BMI Obesity Cancer Outcomes 105

DAIC

JANUARY 4, 2024

Getty Images milla1cf Thu, 01/04/2024 - 11:04 January 4, 2024 — Laguna Tech USA , a privately-held medical technology company dedicated to innovations in structural heart solutions to broaden useability and applicability for patients, today announced that a record number five patients were successfully treated at a single center on the same day with the ZETA Balloon Expandable Aortic Valve System to treat aortic valve disease.

Aortic valve 105

Aortic valve Heart Valves Aortic Technology 105

Becker's Hospital Review - Cardiology

JANUARY 4, 2024

HCA Florida Largo Hospital cardiologists were the first in the state to successfully remove a tumor from inside a patient's heart without open heart surgery.

Open-Heart Surgery 108

Open-Heart Surgery Hospital 108

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated with aggressive disease and poor prognosis. ASXL1 recruits Polycomb repressive complex 2 (PRC2) to specific gene loci to repress transcription through trimethylation of histone H3 on lysine 27 (H3K27me3). ASXL1 alterations reduce H3K27me3 levels, which results in leukemogenic gene expression and the development of myeloid malignancies.

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105

HCPLive

JANUARY 2, 2024

Each 1-day delay in continuous renal replacement therapy initiation was associated with 3% greater odds of major adverse kidney events at 90 days, including mortality, dialysis dependence, and persistent kidney dysfunction.

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Cardiovascular Diabetology

JANUARY 5, 2024

Few studies explored the effect of the combination of glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on the incidence of cardiovascular events in pa.

Myocardial Infarction 106

Myocardial Infarction Diabetes Research 106