Sat.Jul 13, 2024 - Fri.Jul 19, 2024

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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145
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COVID May Affect Type 1 Diabetes in Kids, and Not in a Good Way

Med Page Today

(MedPage Today) -- COVID-19 may accelerate progression of presymptomatic type 1 diabetes in youth, a German study suggested. Incidence of clinical type 1 diabetes nearly doubled after the pandemic started among 591 youth ages 1 to 16 known to.

COVID-19 144
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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

Science Daily - Heart Disease

According to a new study, both 30-year risk for cardiovascular disease in addition to 10-year risk may be considered in making decisions about when to initiate high blood pressure medication.

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Society of Cardiovascular Computed Tomography to Honor Oxford’s Kenneth Chan, MBBS at SCCT2024

DAIC

Kenneth Chan, MBBS, Academic Clinical Research Fellow in the Division of Cardiovascular Medicine at Oxford University Hospitals (UK) will receive the 2024 SCCT Clinical Trials and Registries Award (CTRA) at the opening session of the Society’s 19th Annual Scientific Meeting (SCCT2024) on Friday, July 19 in Washington, DC. christine.book Fri, 07/19/2024 - 09:01 July 18, 2024 — The Society of Cardiovascular Computed Tomography ( SCCT ) has announced it will honor Kenneth Chan, MBBS as recipient of

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The potential anti-arrhythmic effect of SGLT2 inhibitors

Cardiovascular Diabetology

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and reduce renal reabsorpti.

Diabetes 111
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New Alzheimer's Mimic Identified

Med Page Today

(MedPage Today) -- A new memory-loss syndrome that mimics the clinical features of Alzheimer's disease was identified, researchers said. "We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome [LANS.

Research 138
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Baylor St. Luke’s Settles Concurrent Cardiac Surgery Case

CardiacWire

Cardiac surgeon compensation is generally a numbers game – the more procedures you do, the more you make. However, a Medicare fraud settlement featuring some of Houston’s most prominent institutions and cardiac surgeons reveals the pitfalls of this incentive structure. Allegations claim that between 2013 to 2020 three decorated Baylor St. Luke’s heart surgeons regularly operated in two to three rooms simultaneously, while “delegating key aspects of extremely complicated and risky heart sur

Medicare 109

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U.S. News Hospital Rankings Are One Piece of the CHD Care Puzzle

Conquering CHD

Where to receive care is one of the most important decisions a family can make. Conquering CHD has a strong commitment to transparency and ensuring patients and families have essential information at their fingertips when they need it to assist them in making the best choice for their family. With the publishing of this year’s U.S. News & World Hospital Report rankings , we remind you this is only one of many tools you can use to have a conversation with your care team and should not be used

Hospital 105
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Trans People on Hormone Therapy Don't Mind Potential Cardiovascular Side Effects

Med Page Today

(MedPage Today) -- Trans adults using gender-affirming hormone therapy said they were content that it helped their overall well-being and, indirectly, felt it benefited their cardiovascular health, researchers reported. Based on interviews with.

Research 117
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Association of diabetes with cardiovascular calcification and all-cause mortality in end-stage renal disease in the early stages of hemodialysis: a retrospective cohort study

Cardiovascular Diabetology

The main goal of this study was to examine how diabetes, cardiovascular calcification characteristics and other risk factors affect mortality in end-stage renal disease (ESRD) patients in the early stages of h.

Diabetes 105
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Circle Cardiovascular Imaging Announces Leadership Transition

DAIC

Circle Cardiovascular Imaging has announced that Erkan Akyuz has been appointed Chief Executive Officer to succeed Circle co-founder and CEO Greg Ogrodnick. Image courtesy: Circle Cardiovascular christine.book Thu, 07/18/2024 - 13:32 July 18, 2024 — Circle Cardiovascular Imaging , a developer of artificial intelligence (AI)-driven cardiovascular imaging solutions, has announced that Erkan Akyuz has been appointed Chief Executive Officer, effective August 5, 2024.

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Circadian disruption, clock genes, and metabolic health

Journal of Clinical Investigation - Cardiology

A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal and human research to suggest that the expression of core circadian genes, such as circadian locomotor output cycles kaput gene (CLOCK), brain and muscle ARNT-Like 1 gene (BMAL1), period (PER), and cyptochrome (CRY), and the consequent expression

Diabetes 145
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D.C. Hospital Gets a Wake-Up Call to Chagas Disease

Med Page Today

(MedPage Today) -- Researchers from one Washington, D.C., center confirmed that there was a high prevalence of Chagas disease in a sample of Latin American immigrants hospitalized with cardiac conditions. Of 97 adults who underwent a transthoracic.

Hospital 117
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Prevalence and incidence of heart failure in type 2 diabetes patients: results from a nationwide prospective cohort—the DIABET-IC study

Cardiovascular Diabetology

Type 2 diabetes (T2D) patients have an increased risk of heart failure (HF). There are limited data on the association between HF and T2D in specific healthcare settings. This study sought to analyse the preva.

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Elucid Commences International PRE-VUE CCT Registry Study

DAIC

mtaschetta-millane Thu, 07/18/2024 - 09:19 July 18, 2024 — Elucid , a pioneering AI medical technology company providing physicians with imaging analysis software based on ground truth histology to support diagnosis and treatment of cardiovascular disease, has initiated site recruitment for its Plaque as a Risk Factor for Evaluation of Vascular Events (PRE-VUE) CT Registry Study.

Plaque 105
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HBV, HCV Screening Disparities Among Low-Income US Veterans

HCPLive

An analysis of data from the NV-HOPE study calls attention to lower rates of HBV and HCV screening among low-income US veterans versus the general US veteran population.

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The President Was Dying, but His Doctors Zipped Their Lips

Med Page Today

(MedPage Today) -- The patient's blood pressure averaged 209/100 mm Hg, a level now considered to be a medical emergency. His heart was enlarged, his skin was gray due to lack of oxygen in the blood, and an ECG showed signs of terminal cardiac.

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Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation

JAMA Cardiology

This study investigates the impact of lipoprotein(a) levels on long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.

Plaque 111
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AliveCor's Kardia 12L ECG System Receives Category III CPT Codes

DAIC

mtaschetta-millane Thu, 07/18/2024 - 09:05 July 18, 2024 — AliveCor , a global leader in AI-powered cardiology , today announced that the American Medical Association (AMA) has granted new Category III Current Procedural Terminology (CPT) codes that are applicable to the company's Kardia 12L ECG System , which received FDA clearance in June 2024.

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New study finds cardiovascular outcomes better for patients on home hemodialysis

Medical Xpress - Cardiology

Dialysis patients using a more traditional home hemodialysis procedure have lower incidence of cardiovascular disease than patients using a less invasive peritoneal catheter for dialysis at home, according to a study led by a University of Cincinnati College of Medicine researcher.

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VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models

Journal of Clinical Investigation - Cardiology

Pathogenic variants in valosin-containing protein (VCP) cause multisystem proteinopathy (MSP), a disease characterized by multiple clinical phenotypes including inclusion body myopathy, Paget’s disease of the bone, and frontotemporal dementia (FTD). How such diverse phenotypes are driven by pathogenic VCP variants is not known. We found that these diseases exhibit a common pathologic feature: ubiquitinated intranuclear inclusions affecting myocytes, osteoclasts, and neurons.

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Brendon Neuen, MBBS, PhD: Optimizing Cardiorenal Prognosis with GLP-1, SGLT2 Combination

HCPLive

Neuen explains the cardiovascular and kidney benefits of combining SGLT2 inhibitors and GLP-1 receptor agonists in diabetes and the future of combination therapy.

Diabetes 105
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BioCardia Announces United States Patent Issuance on Morph DNA Multi-Directional Steerable Catheter Transseptal Application

DAIC

mtaschetta-millane Wed, 07/17/2024 - 11:06 July 17, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases announced that the Unites States Patent Office has granted Patent No: 12,036,371 titled “Method of Accessing the Left Atrium with a Multi-Directional Steerable Catheter,” with a patent term that will expire in 2035.

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Dietary patterns to promote cardiometabolic health

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 July 2024; doi:10.1038/s41569-024-01061-7 Various dietary patterns have been proposed to improve cardiometabolic health. In this Review, Pagidipati et al. emphasize the commonalities between recommendations on what to eat (Mediterranean, Dietary Approaches to Stop Hypertension and low-carbohydrate or ketogenic diets) and the possible benefits of time-restricted eating and intermittent fasting.

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Artificial intelligence-enabled atrial fibrillation detection using smartwatches: current status and future perspectives

Frontiers in Cardiovascular Medicine

Atrial fibrillation (AF) significantly increases the risk of stroke and heart failure, but is frequently asymptomatic and intermittent; therefore, its timely diagnosis poses challenges. Early detection in selected patients may aid in stroke prevention and mitigate structural heart complications through prompt intervention. Smartwatches, coupled with powerful artificial intelligence (AI)-enabled algorithms, offer a promising tool for early detection due to their widespread use, easiness of use, a

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Sunir J. Garg, MD: Pegcetacoplan Preserves Visual Function on Microperimetry

HCPLive

Pegcetacoplan for 36 months led to fewer absolute scotomatous points on microperimetry than delayed treatment, suggesting its efficacy in preserving vision.

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Edwards Lifesciences to Acquire Innovalve

DAIC

Getty Images mtaschetta-millane Mon, 07/15/2024 - 11:06 July 15, 2024 — Edwards Lifesciences announced it has exercised its option to acquire Innovalve Bio Medical Ltd. , an early-stage transcatheter mitral valve replacement (TMVR) company, following its initial investment in 2017. Since that time, Innovalve has demonstrated progress in its program with promising early clinical experience.

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A Race Against Time: How One Idaho Hospital Added a New CT Suite to Better Serve Its Community

Cassling

Since 2014, Bonner General Health in Sand Point, Idaho, has experienced a staggering 73% increase in the number of CT scans they perform annually. This number is a direct result of the influx of population into the area. With only one CT scanner in the hospital to service outpatients and the emergency room, Bonner General saw an urgent need for expansion in order to better serve its patients.

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Pemafibrate Takes a Small Step Forward in Diabetic Foot Ulcers After CVD Flop

Med Page Today

(MedPage Today) -- Pemafibrate was tied to potential prevention of leg and foot ulcers in type 2 diabetes, a silver lining to the PROMINENT trial's otherwise disappointing cardiovascular results. In an exploratory analysis, pemafibrate was tied.

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Switching to Faricimab Effective for Treatment-Naive Wet AMD

HCPLive

A case series analysis indicated that switching from aflibercept to faricimab could be a safe and effective option for patients with treatment-resistant nAMD.

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Strategic Deal to Deliver Virtual Value-based Cardiology Care Announced by Guidehealth and Story Health

DAIC

A strategic deal to deliver virtual value-based cardiology care to health systems has been announced by the Dallas, TX-based executive team at Guidehealth, a provider of AI-enabled healthcare services and Story Health, a Cupertino, CA-based digital company involved in specialty care delivery. Image courtesy: Guidehealth christine.book Mon, 07/15/2024 - 12:20 July 15, 2024 — Guidehealth , an artificial intelligence (AI)-enabled healthcare services company, has announced a strategic deal with Stor

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Functional control of myosin motors in the cardiac cycle

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 July 2024; doi:10.1038/s41569-024-01063-5 Contraction of the heart is driven by cyclical interactions between myosin and actin filaments driven by ATP hydrolysis. In this Review, Irving summarizes the basal cardiac cycle of the healthy human heart at the ventricular, cellular, sarcomeric, and molecular levels and the implications for the development of novel therapies for heart disease.

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

American Heart News - Heart News

Research Highlights: A comparison of two tools for calculating cardiovascular disease risk found that if only the current 10-year risk thresholds are applied, fewer adults may be recommended for blood pressure-lowering medication. The tools, The.

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RHONE-X: 90% of Patients Treated with Faricimab Free from DME at 4 Years

HCPLive

New data from RHONE-X at ASRS suggest over 90% of DME patients treated with faricimab (Vabysmo) were DME-free at 4 years, with nearly 80% on 3-4 month dosing intervals.

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Ultrahuman Announces its App Store ‘PowerPlugs’ with the World’s First AFib Detection Technology on a Smart Ring

DAIC

mtaschetta-millane Tue, 07/16/2024 - 09:47 July 16, 2024 — Ultrahuman, a pioneer in wearable technology , launches PowerPlugs, a platform for individual apps and plugins built on top of Ultrahuman’s health and wellness data stack. This is the world’s first in a smart ring form factor. Recognizing each individual’s health journey is unique, PowerPlugs enable people to choose and focus on the aspects of their health that matter most.

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Why You Struggle To Lose Weight.

Dr. Paddy Barrett

Over the last few months, I have gained weight, and I needed to lose it. The weight gain was intentional, as I was attempting to add muscle mass. But I overshot. Not by a huge amount, but I ended up about 5 kg (11 lbs) over where I was six months ago. Sure, some of that was muscle mass but by no means all of it. I needed to drop some of that excess weight, so what did I do?

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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

Journal of Clinical Investigation - Cardiology

The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis. Here, we examined the role of the MC3R and the melanocortin system in regulating the response to various anorexigenic agents. The genetic deletion or pharmacological inhibition of the MC3R, or subthreshold doses of an MC4R agonist, improved the dose responsiveness to glucagon-like peptide