Sat.Aug 03, 2024 - Fri.Aug 09, 2024

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Coffee-Dementia Link Continues to Unfurl

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Coffee and tea intake were associated with long-term cognitive changes in older adults, two prospective studies presented at the Alzheimer's Association International Conference (AAIC) suggested. Among 6,001.

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3D-printed blood vessels bring artificial organs closer to reality

Science Daily - Heart Disease

Lab-grown organs are a long-time 'holy grail' of organ engineering that has yet to be achieved, but new research has brought that goal a big step closer to reality using a new 3D-printing method called co-SWIFT. co-SWIFT prints branching networks of double-layered vessels that are infused with smooth muscle cells and endothelial cells into living human cardiac tissue, and can even replicate patient-specific vascular structures,indicating that it could one day be used for personalized medicine.

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FDA Approves Epinephrine Nasal Spray for Emergency Treatment of Allergic Reactions

HCPLive

The FDA approved epinephrine nasal spray (Neffy) for the emergency treatment of allergic reactions, including anaphylaxis, in adult and pediatric patients who weigh at least 30 kg.

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ECG Blog #442 — And then the Patient Arrested.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that that this middle-aged woman noted chest tightness and nausea an hour earlier. QUESTIONS: How would YOU interpret the ECG in Figure-1 ? — IF told that this patient arrested shortly after ECG #1 — Does this change your interpretation? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original EC G using PMcardio ).

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Intermittent Fasting May Improve Memory, Executive Function, Early Trial Suggests

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Intermittent calorie restriction improved executive function and memory measures in cognitively intact older adults, an exploratory pilot study suggested. The 8-week randomized clinical trial of 40 overweight.

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Mechanisms and treatment of pulmonary arterial hypertension

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 07 August 2024; doi:10.1038/s41569-024-01064-4 In this Review, Ghofrani and colleagues discuss the mechanisms underlying the development of pulmonary arterial hypertension, provide an overview of approved therapies and describe the predominantly non-vasodilatory drugs that are currently being tested in clinical trials.

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Digital Consults to Enhance Heart Failure Treatment: The ADMINISTER Trial

Cardiology Update

Despite proven benefits in reducing morbidity and mortality, many heart failure (HF) patients do not receive optimal guideline-directed medical therapy (GDMT). The 2021 European Society of Cardiology guidelines recommend guideline-directed medical therapy (GDMT) for patients with HF with reduced ejection fraction (HFrEF). This includes beta-blockers, ACE inhibitors, ARBs, ARNIs, MRAs, and SGLT2 inhibitors.

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Lupus Organ Damage Most Often Comes Early

Med Page Today

(MedPage Today) -- The biggest risks for organ damage for patients with systemic lupus erythematosus (SLE) come in the first year after diagnosis, analysis of a long-running registry indicated. Among 1,274 members of a large Spanish SLE cohort.

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Eating more fruits and vegetables to reduce dietary acid lowers blood pressure and improves kidney and heart health in patients with hypertension

Science Daily - Heart Disease

Doctors recommend making fruits and vegetables a foundational part of the treatment of patients with hypertension. Diets high in fruits and vegetables are found to lower blood pressure, reduce cardiovascular risk, and improve kidney health due to their base-producing effects. A new study details the findings from a five-year interventional randomized control trial.

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14 Ways To Prevent Dementia

Dr. Paddy Barrett

More than heart disease or cancer, the risk of dementia often creates much greater anxiety in the patients I see. And given that dementia is routinely in the top 5 leading causes of death, this concern is dually warranted. But can dementia be prevented? The answer is yes. But as I have said many, many times in the past, we need to understand that prevention is usually a shorthand way of saying: “Decrease the odds of something early in life” The reason for this is that when it comes t

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Topline Data Prove Finerenone's HFpEF Benefit in FINERARTS-HF Trial

HCPLive

On August 05, 2024, less than a month prior to its presentation at ESC 24, Bayter has announced topline data from the FINEARTS-HF trial indicating finerenone met the primary endpoint.

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Prescription-Free Online Semaglutide Is Risky Business

Med Page Today

(MedPage Today) -- A qualitative study of semaglutide (Ozempic, Wegovy) purchases over the internet without a prescription uncovered scams, low purity levels, and possible contamination of products. Quality testing of semaglutide products purchased.

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Alternative access in transcatheter aortic valve replacement—an updated focused review

Frontiers in Cardiovascular Medicine

Aortic Stenosis (AS) is a common condition with an estimated pooled prevalence of all AS in the elderly population at around 12.4%, with that of severe AS estimated to be around 3.4%. In the past, surgical aortic valve replacement was the primary treatment option for severe AS for decades. However, with the compelling evidence on the safety and efficacy of transcatheter aortic valve replacement (TAVR), it has become the gold standard treatment option for many patients with symptomatic severe AS.

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Trends in prognosis and use of SGLT2i and GLP-1 RA in patients with diabetes and coronary artery disease

Cardiovascular Diabetology

Objective To explore trends in prognosis and use of glucose-lowering drugs (GLD) in patients with diabetes and coronary artery disease (CAD). Research design and methods All patients with diabetes and CAD undergoing a coronary angiography between 2010 and 2021 according to the Swedish Angiography and Angioplasty Registry were included. Information on GLD (dispended 6 months before or after coronary angiography) was collected from the Swedish Prescribed Drug Registry.

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Reduced-Dose Methylprednisolone Improves Kidney Outcomes, Delays Renal Failure in High-Risk IgAN

HCPLive

Findings from a prespecified secondary analysis of the reduced-dose cohort of the TESTING trial suggest the efficacy of a lower dose of oral methylprednisolone in IgA nephropathy.

Outcomes 105
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Poor Physical Function Likely the Main Reason for Higher Fracture Risk in T2D

Med Page Today

(MedPage Today) -- Poor physical function appeared to be the primary reason for increased fracture risk in older women with type 2 diabetes, a prospective observational study suggested. According to Mattias Lorentzon, MD, PhD, of Sahlgrenska University.

Diabetes 105
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Short, intense bursts of exercise more effective after stroke than steady, moderate exercise

Science Daily - Heart Disease

Significant improvements in aerobic fitness were noted after 12 weeks of high-intensity interval training sessions compared to traditional, moderate exercise sessions, according to a new study.

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What does this ECG show?

Dr. Smith's ECG Blog

Written by Pendell Meyers Try first to interpret the ECG without any clinical context: What do you think? Sinus rhythm with abnormal STE in V2-V6, and I, II, aVF. Reciprocal STD in aVR and V1. Most leads with STE have remarkably non-hyperacute, flat T waves. Most would say that there is Spodick's sign. The PR depression in II (and its reciprocal PR elevation in aVR) is probably beyond normal baseline values.

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Hepatic Benefits of GLP-1 RAs Are Independent of Weight Loss in MASLD, Diabetes

HCPLive

Treatment with GLP-1 RAs led to improvements in weight loss, liver function tests, and liver fat in patients with diabetes and MASLD, with hepatic improvements independent of weight loss.

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Aerosmith Retires After Injury; All Zepbound Doses Now Available; Guacamole Recalled

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Rock band Aerosmith announced its retirement, saying that a full recovery of singer Steven Tyler's vocal injury does not appear possible. (People) Belgium withdrew.

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Adding a 9th psychological health metric to life's essential 8 enhances the cardiovascular health construct for predicting mortality risk

Science Daily - Heart Disease

A cardiovascular health construct based on the American Heart Association's Life's Essential 8 but enhanced with a ninth psychological health metric strongly predicts all-cause and cardiovascular mortality.

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46 year old with chest pain develops a wide complex rhythm -- see many examples

Dr. Smith's ECG Blog

Written by Colin Jenkins and Nhu-Nguyen Le with edits by Willy Frick and by Smith A 46-year-old male presented to the emergency department with 2 days of heavy substernal chest pain and nausea. He reported a history of “Wolf-Parkinson-White” and “heart attack” but said neither had been treated. These diagnoses were not found in his medical records nor even a baseline ECG.

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Study Highlights Gender Disparities in Treatment Outcomes for Skin Diseases

HCPLive

These data point to differences between genders such as time to initiation of treatment, treatment choice, response to medication, adverse events, and adherence.

Outcomes 111
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When you have a ‘silent’ heart attack

Heart Sisters

"People often believe that their 'silent' heart attack is something else - like the flu or a pulled muscle. Much later, when they end up getting diagnosed with a heart attack that they didn't know they were having, they might recall an episode of feeling vaguely unwell." - Dr.

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Omega-3 Fatty Acids and Arrhythmias

Circulation

Circulation, Volume 150, Issue 6 , Page 488-503, August 6, 2024. The pro- and antiarrhythmic effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been extensively studied in preclinical and human trials. Despite early evidence of an antiarrhythmic role of n-3 PUFA in the prevention of sudden cardiac death and postoperative and persistent atrial fibrillation (AF), subsequent well-designed randomized trials have largely not shown an antiarrhythmic benefit.

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Rates of Sudden Death After Myocardial Infarction—VALIANT and PARADISE-MI Trials

JAMA Cardiology

This secondary analysis of the Valsartan in Acute Myocardial Infarction (VALIANT) and Prospective ARNi vs ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After MI (PARADISE-MI) randomized clinical trials investigates the changes over time in sudden death rate after myocardial infarction and the characteristics of people dying suddenly.

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Head Injuries Among Law Enforcement Linked to Depression, PTSD

HCPLive

A recent study found a high prevalence of head injuries among law enforcement officers may make them more prone to experiencing mental health issues.

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Renal Denervation for the Treatment of Hypertension: A Scientific Statement From the American Heart Association

Hypertension Journal

Hypertension, Ahead of Print. Hypertension is a leading risk factor for cardiovascular morbidity and mortality. Despite the widespread availability of both pharmacological and lifestyle therapeutic options, blood pressure control rates across the globe are worsening. In fact, only 23% of individuals with high blood pressure in the United States achieve treatment goals.

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Eligibility for Quadruple Therapy in Newly Diagnosed HFrEF

American College of Cardiology

What is the degree to which patients newly diagnosed with heart failure with reduced ejection fraction (HFrEF) are eligible for quadruple medical therapy, and what are the projected benefits of in-hospital initiation?

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ACC updates heart failure care guidelines

Becker's Hospital Review - Cardiology

The American College of Cardiology has updated care guidelines for patients hospitalized with heart failure, according to an Aug. 8 report published in the Journal of the American College of Cardiology.

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Zuranolone Offers New Hope for Treating Postpartum Depression in New Mothers

HCPLive

A year after zuranolone’s FDA approval for postpartum depression on August 3, 2023, prescribers and a patient weigh in about the medication’s success in alleviating symptoms.

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Myeloma Therapy for Monoclonal Gammopathy of Thrombotic Significance

The New England Journal of Medicine

A patient with serious thrombotic episodes was found to have a monoclonal gammopathy of an anti–PF4 antibody. Myeloma therapy reduced the paraprotein level and prevented further thrombotic events.

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ACC CardiaCast: Courtside with the Chair: Shared Decision-Making with Athletes: A Discussion of “How To�? Part 1

American College of Cardiology

In this episode, Dr. Jonathan Kim is joined by Drs. Michael Ackerman, Rachel Lampert, and Matthew Martinez to discuss the “why” and “how to” related to shared decision-making in the context of sports participation for athletes with heart disease.

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2 challenges this cardiology leader expects to face — and how he'll address them

Becker's Hospital Review - Cardiology

In September, Miami Transplant Institute named Hari Mallidi, MD, chief of cardiac surgery and program director of heart transplantation and mechanical circulatory support at MTI, as well as director of the Jackson Heart Institute in Miami.

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FDA Approves OCU400 Expanded Access Program for Retinitis Pigmentosa

HCPLive

Ocugen will initiate expanded access to OCU400 gene therapy in adults with retinitis pigmentosa prior to BLA approval.

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Creative Alliances in Cardiorenal Metabolic Management: A Game Changer (Part 1) 

Cardiometabolic Health Congress

Cardiometabolic risk encompasses a complex spectrum of interrelated conditions, including cardiovascular disease, type 2 diabetes, and metabolic syndrome. These interconnected diseases pose a significant global health threat, with cardiovascular diseases alone accounting for one-third of all deaths worldwide , according to the World Health Organization.

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A Guide to Valve-in-Valve TAVR: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art guide to transcatheter aortic valve (TAV) design and systematic planning for a redo-TAV (TAV-in-TAV) procedure.