Sat.May 11, 2024 - Fri.May 17, 2024

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ECG Blog #430 — Just a Regular LBBB ECG?

Ken Grauer, MD

The ECG in Figure-1 — was obtained from an older man who had just completed dialysis — and , is now complaining of abdominal discomfort that radiates to his chest. The consultant interpreted this tracing as “LBBB” ( L eft B undle B ranch B lock ) — but not indicative of anything acute. QUESTIONS: Do you agree with the consultant’s interpretation? How would YOU approach this case?

Blog 156
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Artificial intelligence tool to improve heart failure care

Science Daily - Heart Disease

The powerful new AI tool can predict heart failure outcomes in specific patients, helping doctors improve care.

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Transcutaneous Pacing: Part 2

EMS 12-Lead

TCP in the ROSC Patient: False Electrical Capture at 75mA Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the second installment of a blog series showing how transcutaneous pacing (TCP) can be difficult and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.

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Evaluating Safety of Novel LDL Management Mechanism

HCPLive

Deepak Bhatt, MD, MPH, MBA, reviews the efficacy and safety data of inclisiran, highlighting its long-term effects and noting that injection site reactions are among the most prominent adverse reactions associated with this medication.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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New Treatment in Pipeline for Patients with Hypertrophic Cardiomyopathy

DAIC

Getty Images milla1cf Tue, 05/14/2024 - 13:00 May 14, 2024 — One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity.

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New drug makes exercise, everyday tasks easier for people with common heart condition

Science Daily - Heart Disease

People with the heart condition obstructive cardiomyopathy were able to use significantly more oxygen while exercising after taking the investigational drug aficamten, according to a new study.

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Early repol or anterior OMI?

Dr. Smith's ECG Blog

Chest Pain – Benign Early Repol or OMI? Written by Destiny Folk, MD, Adam Engberg, MD, and Vitaliy Belyshev MD A man in his early 60s with a past medical history of hypertension, type 2 diabetes, obesity, and hyperlipidemia presented to the emergency department for evaluation of chest pain. He reported substernal chest pressure with radiation to his left arm that started at work several hours prior to arrival and had somewhat improved since onset.

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The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development

Journal of Clinical Investigation - Cardiology

Lymphedema is a debilitating disease with no effective cure and affects an estimated 250 million individuals worldwide. Prior studies have identified mutations in piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) in patients with primary lymphedema. Here, we identified crosstalk between these molecules and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells (

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Two decades of studies suggest health benefits associated with plant-based diets

Science Daily - Heart Disease

Vegetarian and vegan diets are generally associated with better status on various medical factors linked to cardiovascular health and cancer risk, as well as lower risk of cardiovascular diseases, cancer, and death, according to a new review of 49 previously published papers.

Diet 120
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Singing repairs the language network of the brain after a cerebrovascular accident

Science Daily - Stroke

Singing rehabilitates speech production in post-stroke aphasia. Researchers investigated the rehabilitative effect of singing on the brain.

Research 122
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Low Testosterone Linked With Mortality Risk in Aging Men

Med Page Today

(MedPage Today) -- A low serum testosterone level at baseline was associated with higher risk for all-cause and cardiovascular disease (CVD) mortality, a meta-analysis of 11 prospective cohort studies found. In age-adjusted analyses, men in the.

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New postpartum care recommendations target CVD risk

American Heart News - Heart News

DALLAS, May 16, 2024 — Pregnancy-related deaths in the U.S. have risen 140% over the past three decades and cardiovascular disease is the leading cause.[1] Despite existing medical guidance on pregnancy and cardiovascular health, current trends in health.

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New cardiac research will save women's lives by improving detection of heart failure

Science Daily - Heart Disease

An important new study has advanced how heart failure is detected in women -- meaning more female patients can be diagnosed and at an earlier stage.

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Researchers develop 'game-changing' blood test for stroke detection

Science Daily - Stroke

Stroke is the leading cause of disability worldwide and the second leading cause of death, but the right early intervention can prevent severe consequences. Scientists developed a new test by combining blood-based biomarkers with a clinical score to identify patients experiencing large vessel occlusion (LVO) stroke with high accuracy.

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Draw Between Two Diuretics for Renal Prevention in Hypertension

Med Page Today

(MedPage Today) -- LONG BEACH, Calif. -- Chlorthalidone was no better than hydrochlorothiazide for reducing the incidence of major renal outcomes in patients with hypertension, a secondary analysis of the randomized Diuretic Comparison Project.

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Tildrakizumab Effective for Patients with Psoriasis Unresponsive to Anti-IL17

HCPLive

A study showed tildrakizumab treated difficult-to-treat psoriasis areas in patients who failed anti-IL17 treatment.

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Infertility treatment doubles the risk of postpartum heart disease

Science Daily - Heart Disease

Researchers tie infertility treatment to a particular risk for hypertensive diseases.

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Ep 194 Subarachnoid Hemorrhage – Recognition, Workup and Diagnosis Deep Dive

ECG Cases

Anton is joined by the world's leading EM researcher in subarachnoid hemorrhage diagnosis Dr. Jeff Perry and EM-Stroke team clinician Dr. Katie Lin for a deep dive into why we still miss this life-threatening diagnosis, the key clinical clues, proper use of decision tools, indications for CT, indications for CTA, indications for LP and CSF interpretation for the sometimes elusive diagnosis of subarachnoid hemorrhage.

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Teen Died From Eating Spicy Chip as Part of Social Media Challenge, Autopsy Says

Med Page Today

(MedPage Today) -- A Massachusetts teen who participated in a spicy tortilla chip challenge on social media died from eating a large quantity of chili pepper extract and also had a congenital heart defect, according to an autopsy report obtained.

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RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication

Journal of Clinical Investigation - Cardiology

The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of somatic cells. Although Rnf4–conditional-knockout B cells exhibited substantial genomic instability, Rnf4 deletion caused no increase in tumor susceptibility.

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Normothermic perfusion system extends life of organs waiting for transplant

Science Daily - Heart Disease

In the United States, about 30-40% of donor hearts aren't considered for transplant due to inadequate function in the donor. This leads to a drop in the number of donated hearts that are available to be matched with someone who needs a heart transplant.

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Improving Life Quality in Chronic Limb-Threatening Ischemia Through Revascularization

DAIC

milla1cf Thu, 05/16/2024 - 15:35 May 16, 2024 — A recent publication in the American Heart Association Circulation highlights a comprehensive investigation to assess the impact of revascularization strategies on the health-related quality of life (HRQoL) of patients suffering from chronic limb-threatening ischemia. This study stands as a pivotal exploration into the comparative effectiveness of surgical bypass (Bypass) versus endovascular intervention (Endo) across multiple patient cohorts.

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Yet Another Benefit for Metformin?

Med Page Today

(MedPage Today) -- Metformin started for pre-diabetes also appeared to reduce patients' risk of developing gout, researchers found. Among 1,154 people with elevated hemoglobin A1c (HbA1c) just short of the threshold for type 2 diabetes who began.

Diabetes 111
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Hidradenitits Suppurativa Linked to Increased Risk of Cardiovascular Diseases

HCPLive

Patients with hidradenitis suppurativa had the greatest risk of developing various CVS, with heart failure being the most common one.

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Endeavor Health opens $170M cardiovascular institute

Becker's Hospital Review - Cardiology

Discover the new state-of-the-art Cardiovascular Institute at Glenbrook Hospital in Evanston, IL, offering advanced heart care and future expansion plans.

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Trends Shaping the Cardiovascular Information Systems Market

DAIC

In the dynamic realm of healthcare technology, cardiovascular information systems (CVIS) stand at the forefront, facilitating streamlined operations, enhanced patient care and efficient data management within cardiovascular departments. According to a recent market report from Credence Research, the CVIS market is projected to surge from $1,197 M in 2023 to $2,387 by 2023 — a compound annual growth rate of 7.7%.

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Liver Disease, High Lipoprotein(a) Tied to Higher MI Risk in Diabetes Patients

Med Page Today

(MedPage Today) -- NEW ORLEANS -- Individuals with diabetes were more likely to report a history of myocardial infarction (MI) if they also had high levels of serum lipoprotein(a), or Lp(a), or advanced liver fibrosis, a retrospective study using.

Diabetes 110
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Febuxostat Use Is Linked to Reduced Risk of Kidney Events for Patients with Gout

HCPLive

A new study found febuxostat can effectively delay the progression of kidney function deterioration in patients with gout.

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The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Journal of Clinical Investigation - Cardiology

Lactylation has been recently identified as a new type of posttranslational modification occurring widely on lysine residues of both histone and nonhistone proteins. The acetyltransferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A, is about 1,000 times lower than that of acetyl-CoA, raising the question of whether p300 is a genuine lactyltransferase.

Cancer 109
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CardioFocus to Present Data Supporting Next Generation Pulsed Field Ablation Systems at Heart Rhythm 2024

DAIC

milla1cf Wed, 05/15/2024 - 19:05 May 15, 2024 — CardioFocus, Inc. , a medical device company dedicated to advancing ablation treatment for cardiac arrythmias, announced its participation at the Heart Rhythm 2024 conference, taking place in person at the Boston Convention & Exhibition Center and virtually, May 16-19, 2024. CardioFocus will feature its portfolio of innovative ablation systems which optimize lesion creation via confirmed tissue contact and sophisticated energy delivery.

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ECG Blog #429 — Mobitz I or Mobitz II?

Ken Grauer, MD

The 12-lead ECG and long lead II rhythms shown in Figure-1 — was obtained from an older man with a recent history of “easy fatiguability” and a presyncopal episode. QUESTIONS: How would YOU interpret the ECG in Figure-1 ? Is the group beating due to the Mobitz I or Mobitz II type of 2nd-degree AV block? Figure-1: The initial ECG in today’s case. MY Initial Thoughts on Today’s CASE: For clarity, given the above clinical history — I present my initial thoughts regarding clinical interpretation of

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MaineHealth to open $580M heart hospital

Becker's Hospital Review - Cardiology

MaineHealth's new $580 million Malone Family Tower in Portland offers state-of-the-art cardiac care with 96 rooms, 10 operating rooms, and more.

Hospital 107
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Early diagnosis & treatment of peripheral artery disease essential to improve outcomes, reduce amputation risk

American Heart News - Heart News

Guideline Highlights: The new joint guideline from the American Heart Association and the American College of Cardiology provides recommendations to guide clinicians in the treatment of patients with lower extremity peripheral artery disease (PAD) and.

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GE HealthCare and Medis Medical Imaging Announce Collaboration Focused on Non-Invasive Coronary Assessments to Help Advance Precision Care in Treatment of Coronary Artery Disease

DAIC

milla1cf Tue, 05/14/2024 - 12:53 May 14, 2024 — GE HealthCare , a leading global medical technology, pharmaceutical diagnostics and digital solutions innovator, and Medis Medical Imaging , a leading cardiac imaging software company, announced their collaboration aimed at helping advance precision care in the diagnosis and treatment of coronary artery disease ( CAD ).

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Iptacopan Treatment Significantly Reduces Proteinuria in IgAN

HCPLive

Patients with IgAN receiving iptacopan achieved a 38.3% reduction in proteinuria at month 9.

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Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment

Journal of Clinical Investigation - Cardiology

Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remain unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass.

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