Dr. Paddy Barrett

FEBRUARY 14, 2025

“Cholesterol does not cause heart disease.“ “Statins do not prevent heart attacks.” These are two statements you will hear repeatedly on social media. Usually made by those who really don’t understand what they are saying but increasingly by doctors who really should know better. In the middle of this hurricane of noise are people who just want to know what to do so they don’t have a heart attack at a young age.

Cholesterol 112

Cholesterol Heart Disease Heart attacks Heart Attack 112

CardiacWire

FEBRUARY 12, 2025

Just a couple weeks after the full trial results of AZALEA TIMI 71 were released, Novartis agreed to acquire Anthos Therapeutics for $925M upfront and another $2.15B in milestone payments, signaling that the pharma titan may have renewed confidence in abelacimab and the Factor XI inhibition segment. Novartis spun out the testing and development of abelacimab and formed Anthos Therapeutics back in 2019.

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AFIB Embolism Plaque Stroke 102

Circulation

FEBRUARY 13, 2025

Circulation, Ahead of Print. Critical care cardiology refers to the practice focus of and subspecialty training for the comprehensive management of life-threatening cardiovascular diseases and comorbid conditions that require advanced critical care in an intensive care unit. The development of coronary care units is often credited for a dramatic decline in mortality rates after acute myocardial infarction throughout the 1960s.

Critical Care 72

Critical Care Myocardial Infarction Research Cardiovascular Disease 72

Nature Reviews - Cardiology

FEBRUARY 11, 2025

Nature Reviews Cardiology, Published online: 12 February 2025; doi:10.1038/s41569-025-01137-y Differing definitions and questionable prognostic significance have caused confusion and controversy around the applicability of the current definitions of periprocedural and perioperative myocardial infarction in clinical practice. In this Clinical Outlook, we review the definitions and the clinical and prognostic relevance of the various entities and provide implications for clinical practice.

Myocardial Infarction 73

Myocardial Infarction 73

Physiologically Speaking

FEBRUARY 14, 2025

Greetings! Welcome to the Physiology Friday newsletter. If you’re looking for a new (mess-free) way to fuel your workouts, you should check out Intra Chew—it’s a workout gummy bear made by one of my friends that has carbohydrates and electrolytes. I’ve been using them during all of my long bike rides and before runs. At the very least, it’s something you should try once, and you can get 20% off using the code BRADY20 on the site.

Physiology 85

Physiology Exercise Research Dementia 85

DAIC

FEBRUARY 10, 2025

tim.hodson Mon, 02/10/2025 - 12:43 Feb. 6, 2025 Eko Health, a leader in applying artificial intelligence (AI) for the early detection of heart and lung diseases, recently announcedpublication of a peer-reviewed study evaluating its novel algorithm for the detection of pulmonary hypertension (PH). The study, which was published in the Journal of the American Heart Association (JAHA), highlighted the algorithms ability to analyze heart sounds recorded with a digital stethoscope for identifying ele

Research 64

Research Innovation Pulmonary Hypertension 64

Science Daily - Heart Disease

FEBRUARY 11, 2025

Newborns with heart complications can rely on their newly developed immune systems to regenerate cardiac tissues, but adults aren't so lucky. After a heart attack, most adults struggle to regenerate healthy heart tissue, leading to scar-tissue buildup and, often, heart failure. A new study in experimental animals reveals a critical difference in how macrophages -- a part of the immune system -- help repair the heart in newborns versus adults after a heart attack.

Heart attacks 64

Heart attacks Heart Attack Heart Failure 64

Heart BMJ

FEBRUARY 12, 2025

Background Atrial arrhythmias (AA) and heart failure (HF) are major causes of hospitalisation in adult congenital heart disease (ACHD). This study aimed to evaluate the temporal relationship between AA and HF onset, the association between HF and the success of radiofrequency ablation (RFA), and how HF influences outcomes in patients with AA. Methods In this single-centre retrospective cohort study, data from 3995 patients with ACHD were analysed.

Congenital Heart Disease 59

Congenital Heart Disease Heart Failure Congenital Arrhythmia 59

Medical Xpress - Cardiology

FEBRUARY 14, 2025

Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidney disease with additional cardiovascular risk factors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher.

Heart attacks 139

Heart attacks Heart Attack Research Kidney Disease 139

DAIC

FEBRUARY 14, 2025

tim.hodson Fri, 02/14/2025 - 14:32 Feb. 12, 2025 Orchestra BioMed Holdings, a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, recently made anoral presentation of data on the benefits of atrioventricular interval modulation (AVIM) therapy on patients with diastolic dysfunction at the Technology and Heart Failure Therapeutics (THT) 2025 Conference in Boston, Mass.

Blood Pressure 52

Blood Pressure Heart Failure Hypertension Technology 52

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

BackgroundSystemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection between PIV and CHD especially in elderly people, as well as the diagnostic value of PIV combined with controlling nutritional status (COUNT) score for CHD.MethodsParticipants eligible for the study wer

Heart Disease 52

Heart Disease Research 52

Heart BMJ

FEBRUARY 12, 2025

In adults with congenital heart disease (ACHD patients), atrial arrhythmias (AA) and heart failure (HF) are common. Of these, AA is one of the leading causes for hospital admissions in ACHD care. 1 Factors related to congenital heart disease, such as underlying anatomy, surgical repair technique and scars, can all be considered as AA substrates. Scar-related re-entrant atrial tachycardias and atrial fibrillation (AF) are the most common types of AA, but focal atrial tachycardias, atrioventricula

Congenital Heart Disease 59

Congenital Heart Disease Congenital Heart Failure Arrhythmia 59

Open Heart

FEBRUARY 11, 2025

Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined. This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease. Methods The SingHEART study is a population-based cohort in which individuals underwent ambulatory blood pressure (BP) monitoring, cardiac MRI to measure indexed LV mass index (LVMI) and

Blood Pressure 52

Blood Pressure Atherosclerosis Risk Factors Hypertension 52

Cardiometabolic Health Congress

FEBRUARY 10, 2025

Obesity is a complex, chronic condition that significantly impacts cardiometabolic health and overall well-being. While management can be challenging, research-backed behavioral strategies are delivering promising results. Healthcare professionals can empower patients to achieve sustainable weight loss through practical lifestyle interventions. #1 Dietary Modifications: Evidence-Based Approaches Low-Fat vs.

Obesity 52

Obesity Diet Exercise Diabetes 52

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2025

BackgroundCurrent evidence suggests that cardiovascular disease (CVD) plays a role in the progression of chronic obstructive pulmonary disease (COPD). However, the relationship between CVD and the severity of COPD remains inadequately understood. Therefore, this study aims to elucidate the association between CVD and the severity of COPD.MethodsIn this cross-sectional study involving 7,152 individuals with COPD., Logistic regression, subgroup and sensitivity analyses were employed to evaluate th

Pulmonary 52

Pulmonary Cardiovascular Disease BMI Hypertension 52

Heart BMJ

FEBRUARY 12, 2025

Background Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, often leading to complications such as thoracic aortic aneurysms and aortic stenosis. While BAV is frequently associated with 22q11.2 deletion syndrome (22q11.2DS), the contribution of rare copy number variants (CNVs) in this region to non-syndromic BAV is less clear.

Aortic valve 52

Aortic valve Bicuspid/Mitral Aortic Aneurysm 52

Open Heart

FEBRUARY 10, 2025

Background and objective This review compares non-laboratory-based and laboratory-based cardiovascular disease (CVD) risk prediction equations in populations targeted for primary prevention. Design Systematic review. Methods We searched five databases until 12 March 2024 and used prediction study risk of bias assessment tool to assess bias. Data on hazard ratios (HRs), discrimination (paired c-statistics) and calibration were extracted.

Laboratory 52

Laboratory Cholesterol Cardiovascular Disease Diabetes 52

Cardiovascular Diabetology

FEBRUARY 13, 2025

Since the arrival of continuous glucose monitoring (CGM), the relationship between the glucose management indicator (GMI) and HbA1c has been a topic of considerable interest in diabetes research. This study ai.

Diabetes 127

Diabetes Atherosclerosis Research 127

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

BackgroundChronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiovascular risk in CCS. Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy.

Blood Pressure 52

Blood Pressure Pharmacology Document Risk Factors 52

Heart BMJ

FEBRUARY 12, 2025

Fabry disease (FD) is a rare X-linked genetic lysosomal storage disorder characterised by glycosphingolipid accumulation leading to multiorgan involvement including the heart typically in the second to fourth decades of life. Cardiomyopathy is a primary determinant of prognosis in FD and typically presents as a heart failure (HF) with a preserved ejection fraction phenotype. 1 Early identification and treatment are essential to mitigate disease progression leading to proposals for clinical stagi

Exercise 52

Exercise Preserved Ejection Fraction Cardiomyopathy Heart Failure 52

Open Heart

FEBRUARY 11, 2025

Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of cardiovascular diseases. However, clopidogrel responsiveness shows variability based on CYP2C19 polymorphism. Therefore, we planned a study with an objective of evaluating safety, tolerability, pharmacodynamics and pharmacokinetics of a novel thienopyridine antiplatelet agent AT-10 in healthy Indian subjects compared with standard dosage regimen of clopidogrel based on their

Cardiovascular Disease 52

Cardiovascular Disease 52

DAIC

FEBRUARY 14, 2025

Lorraine and Bill Dodero tim.hodson Fri, 02/14/2025 - 15:33 Feb. 10, 2025 A generous gift of $5 million from Lorraine and Bill Dodero will establish the Lorraine and Bill Dodero Limb Preservation Center at University Hospitals Harrington Heart & Vascular Institute in Cleveland, Ohio. Led by Mehdi Shishehbor DO, MPH, PhD, interventional cardiologist and a pioneer in the field of limb preservation, the Dodero Center will revolutionize care for patients at risk of losing a leg due to peripheral ar

Peripheral Arterial Disease 52

Peripheral Arterial Disease Cancer Innovation Best Practices 52

Frontiers in Cardiovascular Medicine

FEBRUARY 11, 2025

BackgroundIndividuals diagnosed with type 2 diabetes mellitus (T2DM) commonly exhibit elevated lipid levels and an increased body mass index (BMI). The impact of BMI on the efficacy of statins in reducing lipid levels among diabetic patients remains uncertain. We aim to evaluate whether BMI will affect the lipid-lowing effects of statins in patients with T2DM.MethodsIn this retrospective analysis, we screened T2DM patients who were prescribed statins and underwent a 1-year outpatient follow-up r

BMI 52

BMI Diabetes Obesity Outpatient 52

Journal of the American Heart Association

FEBRUARY 8, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundIschemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent stroke models. However, reperfusion therapies remain the only clinically efficacious intervention to date. Rigor and reproducibility are now recognized as critical to bridge the preclinicalclinical disconnect.

Ischemia 45

Ischemia Stroke Strokes Outcomes 45

Physiologically Speaking

FEBRUARY 10, 2025

This week marked week 2 of my 12-week marathon training block which I’m referring to as the “Road to Boston.” Each week I’ll share details about my training, some insights, and other musings as I train for the 2025 Boston Marathon. I’m excited to announce that this training log is being brought to you exclusively by STRYD running pods.

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DAIC

FEBRUARY 12, 2025

tim.hodson Wed, 02/12/2025 - 15:04 Feb. 12, 2025 On Feb. 11, 2025, at HonorHealth Research Institute, Rahul Doshi, M.D., cardiac electrophysiologist, performed one of the nations first procedures to control atrial fibrillation (Afib) using a new type of catheter that can deliver two different types of electrical energy or ablation to destroy the damaged part of the heart that is triggering the abnormal heartbeats.

AFIB 52

AFIB Research Ablation Atrial Fibrillation 52

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

BackgroundWeight-adjusted-waist (WWI) is a novel indicator of obesity that reflects the degree of central obesity in the human body.ObjectivesThe study aimed to explore the relationship between WWI and mortality in hypertensive individuals.MethodsCross-sectional data from the 20012018 National Health and Nutrition Examination Survey (NHANES) dataset were used in this study.

Hypertension 52

Hypertension Obesity Cardiovascular Disease Research 52

HCPLive

FEBRUARY 12, 2025

Meta-analysis suggests iron therapy lowers the risk of heart failure hospitalization and cardiovascular death in patients with chronic kidney disease.

Heart Failure 120

Heart Failure Kidney Disease Hospital 120

Med Page Today

FEBRUARY 10, 2025

(MedPage Today) -- Higher levels of high-density lipoprotein cholesterol (HDL-C) were associated with an increased risk of glaucoma, while high levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides were associated.

Cholesterol 120

Cholesterol 120

JAMA Cardiology

FEBRUARY 11, 2025

This Viewpoint advocates for prompt aortic valve replacement (rather than clinical surveillance) as the default strategy for patients with asymptomatic severe aortic stenosis.

Aortic valve 111

Aortic valve Aortic Stenosis 111

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

BackgroundThis study examines the anatomical characteristics of the mitral isthmus (MI) and its spatial relationship with the esophagus in patients undergoing atrial fibrillation ablation, using cardiovascular computed tomographic angiography (CTA). Understanding this relationship is crucial to minimize the risk of esophageal injuries during ablation procedures.MethodsThe investigation included 300 participants, divided into 200 subjects in the experimental group undergoing atrial fibrillation a

Atrial Fibrillation 52

Atrial Fibrillation Bicuspid/Mitral Ablation Research 52

Medical Xpress - Cardiology

FEBRUARY 10, 2025

Potassium supplements in salt were associated with reduced rates of recurrent stroke and mortality in a large-scale cluster randomized clinical trial involving patients in rural northern China. Findings come from a subgroup (stroke patients) analysis within the original Salt Substitute and Stroke Study (SSaSS), an international study conducted in China.

Stroke 110

Stroke Strokes 110

Med Page Today

FEBRUARY 13, 2025

(MedPage Today) -- In this video, Mikhail Varshavski, DO, who goes by "Dr. Mike" on YouTube, and friends look at the innovations in medicine they're excited about. Following is a partial transcript of the video (note that errors are possible.

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Innovation 111

Science Daily - Heart Disease

FEBRUARY 14, 2025

New research shows sotagliflozin is the only drug in its class to demonstrate these results.

Heart attacks 106

Heart attacks Heart Attack Kidney Disease Heart Failure 106

Frontiers in Cardiovascular Medicine

FEBRUARY 10, 2025

Despite its known correlations with risk of cardiovascular disease, awareness and testing for Lipoprotein (a) lags that of other serological markers with estimates that less than 1% of the US population have undergone screening. Herein we outline how digital tools framed around motivational models (COM-B and SEM), might help increase likelihood of patients seeking Lp(a) testing as part of their managed care.

Cardiovascular Disease 52

Cardiovascular Disease Biomarkers Obesity Outcomes 52

Journal of Cardiovascular Electrophysiology

FEBRUARY 11, 2025

ABSTRACT Background The use of cardiac implantable electronic devices (CIEDs) continues to grow. Despite the presence of implanted hardware, patient compliance with in-clinic visits and remote transmissions is poor. We performed a quality improvement (QI) initiative to assess and optimize CIED follow-up in the New England area. Methods A regional network of eight pediatric institutions was created.

Pediatrics 40

Pediatrics Article 40

Medical Xpress - Cardiology

FEBRUARY 10, 2025

In patients with symptoms such as irregular heartbeats, dizziness, or fainting, or in individuals that physicians suspect may have atrial fibrillation, many days of ECGs may be required for diagnosis"long-term ECG recordings." These recordings must then undergo a time-consuming and human resource-intensive review to identify heart rhythm abnormalities.

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Atrial Fibrillation Heart Rhythm 103